Abstract
Reye’s syndrome was diagnosed in about 15% of cases of encephalopathy syndrome admitted in hospital. Hypoglycemia, considered a hallmark of the disease, was an uncommon observation particularly in patients beyond one year of age (8.5%). Transaminases were more useful than hypoglycemia for suspecting this syndrome (raised in 80% of cases). Progression of the disease was very rapid. The existing management is very unsatisfactory. 11 out of 12 cases died. A high order of suspicion in a patient who presents with vomiting, hepatomegaly and sensorial obtundation is proposed for early diagnosis.
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Reye RDK, Morgan G, Baral J: Enccphalopathy and fatty degeneration of the viscera. A disese entity in childhood. Lancet 2: 749, 1963
Carey L, Rubin RJ: Reye’s syndrome 1974: An epidemiological assessment.In, Pollack JD (ed): Reye’s syndrome Grune and Stratton. New York, San Franeisco, London, 1975, p. 179
Thaler MM, Bruhn FW, Applebaum MN, Goodman J: Reye’s syndrome in twins. J Pediatr 77: 638, 1970
Glasgow JFT, Halliday HL: Recurrence of of Reye’s syndrome. Lancet 1: 974, 1976
De Vivo DC, Keating JP, Haymond MW: Acute encephalopathy with fatty infiltration of the viscera, Ped Clin North Am 23: 527, 1976
Bourgeois CH: Encephalopathy and fatty viscera. A possible response to acute aflatoxin poisoning,In, Pollack JD (ed): Reye’s syndrome, Grune and Stratton. New York, San Francisco, London. 1974, p 131
Bressler R, Carredor C, Brevdel K: Hypoglycin and hypoglycin like compounds. Pharmacol Rev 21: 105, 1969
Linnemann CC, Sheal L, Partin JC, Schubert WK, Schiff GM: Reye’s syndrome: Epidemiologic and viral studies, 1963–1974. Am J Epidemiol 101; 517, 1975
Hilly MD: Etiology of Reye’s syndrome. Grune and Stratton. New York, San Frabcisco, London 1975, p 383
Thaler MM: Metabolic mechanisms in Reye’s syndrome. Am J Dis Child 130; 241, 1976
Chandrasekaran R, Kumar V, Banerjee L, Walia BNS, Bhagwat AG: Reye’s syndrome: Clinical course and follow up of survivors. Indian Pediatr 10: 377, 1973
Deshpande DH, Shrinivas HV, Vasudev Rao T: Reye’s syndrome, report of six autopsied cases. Indian Pediatr 17: 3, 1910
Carey L, Rubin RJ, Bregman D, Gregg MB: Diagnostic criteria for Influrnza B-associated Reye’s syndrome: clinical Vs pathologic criteria. Pediatrics 60: 702, 1977
Huttcnlocher PR and Trauner DA: Reye’s syndrome.In, Vinken PJ and Bruyn GW (Eds): Handbook of Clinical Neurology. Vol. 29, North Holland Publishing Company, Amsterdam-New York-Oxford. 1977, p 331
Huttenlocher PR, Trauner DA: Reye’s syndrome in infancy. Pediatrics 62: 84, 1978
Lovejoy FH, Smith AL, Brarman JN, Wood DI, Victor, Adams PG: Clinical staging in Reye’s syndrome. Am J Dis Child 128: 36, 1974
Thaler WM: Reye’s syndrome cause and effect relationshipIn, Berenberg SR (ed); Liver Diseases in Infancy and Childhood. Martiner Nijeoff Med Div Hague, 1976, p 27
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Kalra, V., Sachdev, H.P.S. & Menon, P.S.N. Reyes’s syndrome in Delhi. Indian J Pediatr 48, 585–588 (1981). https://doi.org/10.1007/BF02821577
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DOI: https://doi.org/10.1007/BF02821577