Abstract
Factor Ei isolated fromListeria monocytogenes caused in rabbits 1 d after intravenous administration activation of peripheral blood lymphocytes in terms of rRNA biosynthesis. Increase of the number of these active lymphocytes was observed not only in peripheral blood, but also in spleen, lung, kidney and liver. When the number of lymphocytes was related to the amount of the organ tissue cells, the increment appeared significant only in the liver where the number of active lymphocytes exceeded the control value by one order of magnitude. Based upon this observation we concluded that the accumulation ofListeria factor Ei activated lymphocytes occurred in liver. This characteristic is considered an additional immunomodulative property ofListeria factor Ei similar to theEscherichia coli lipopolysaccharide.
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Dedicated to Professor C. John on the occasion of his 75th birthday
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Janoutová, J., Mára, M. & Likovský, Z. Accumulation of activated lymphocytes in liver ofListeria factor Ei treated rabbits. Folia Microbiol 40, 652–654 (1995). https://doi.org/10.1007/BF02818524
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DOI: https://doi.org/10.1007/BF02818524