Abstract
The interaction of type-I β-lactamases fromEnterobacter cloacae with diverse β-lactam compounds was examined. The ability of penicillin and cefoxitin to induce β-lactamase production in this strain was assessed. The effect of β-lactamase inhibitors was measured on β-lactamase extracts and on intact cells.E. cloacae 78 strain is a stably derepressed mutant showing limited susceptibility to a number of antibiotics except imipenem. Imipenem would therefore be the appropiate choice for therapy of infections caused by stably derepressed mutants ofEnterobacter sp. producing type-I β-lactamases.
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References
Bellido F., Pechère J.C., Hancock R.E.: Reevaluation of the factors involved in the efficacy of new β-lactams againstEnterobacter cloacae.Antimicrob. Agents Chemother. 35, 73–78 (1991).
Bush K., Sykes R.B.: Methodology for the study of β-lactamases.Antimicrob. Agents Chemother. 30, 6–10 (1986).
Li J.T., Moosdeen F., Williams J.D.: The effect of inhibitors of β-lactamases on β-lactamase extracts and on intact cells.J. Antimicrob. Chemother. 9, 287–296 (1982).
Maniatis T., Fritsh E.F., Sambrook J.:Molecular Cloning, a Laboratory Manual. Cold Spring Harbor Laboratory Press, New York 1982.
Miró E., Alonso C., Navarro F., Mirelis B., Prats G.: Resistencia al imipenem enEnterobacter aerogenes.Enferm. Infecc. Microbiol. Clin. 13, 278–282 (1995).
Navarro F., Alonso C., Ballús J., Miró E., March F., Coll P., Mirelis B.: Relevancia clínica de las bacterias gramnegativas que poseen betalactamasa cromosómica inducible en una unidad de cuidados intensivos.Enferm. Infecc. Microbiol. Clin. 14, 171–176 (1996).
Okonogi K., Sugiura M., Kuno M., Higashide E., Kondo M., Imada A.: Effect of β-lactamase induction on susceptibility to cephalosporins inEnterobacter cloacae andSerratia marcescens.J. Antimicrob. Chemother. 16, 31–42 (1985).
Sanders C.C., Sanders W.E.: Type-I β-lactamases of Gram-negative bacteria: interactions with β-lactam antibiotics.J. Infect. Dis. 154, 792–800 (1986).
Shannon K., King A., Phillips I.: β-Lactamases with high activity against imipenem and Sch 34343 fromAeromonas hydrophila.J. Antimicrob. Chemother. 17, 45–50 (1986).
Suginaka H., Kotani N., Takata N., Ogawa M.: Effect of cefotaxime (HR-756) on biosynthesis of cell wall peptidoglycan inPseudomonas aeruginosa KM 338 andEscherichia coli K12.FEMS Microbiol. Lett. 8, 79–82 (1980).
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Tejedor-Junco, M.T., González-Martín, M., Lupiola, P. et al. Type I β-lactamases ofEnterobacter cloacae and resistance to β-lactam antibiotics. Folia Microbiol 43, 683–686 (1998). https://doi.org/10.1007/BF02816390
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DOI: https://doi.org/10.1007/BF02816390