Folia Microbiologica

, Volume 37, Issue 5, pp 331–345 | Cite as

Physiological similarity and bioreactor scale-up

  • J. Votruba
  • M. Sobotka
Review

Abstract

An economically effective transfer of biological processes from laboratory to production scale is the main task of microbial process engineering. In contrast to the principle of geometrical, chemical, thermal, hydrodynamic or chemical similarity, recommended for scale-up of chemical reactors we propose the principle of physiological similarity. According to this principle same the microenvironment of the living cell must be established to reproduce the same physiological function (e.g. growth, product formation or substrate consumption rates) in the large scale bioreactor as in the laboratory one.

List of symbols

a

exponent in rate equations (see Table II)

b

birth rate

c

specific heat

C

concentration

d

death rate or impeller diameter

D

diffusion coefficient or diameter

g

gravity constant

k, K

kinetic constants (see Table II)

kLa

aeration capacity

L

length

n

rotation speed

p, P

pressure (quantity and dimension)

R

reaction rate

SR

reaction heat

v, V

velocity (quantity and dimension)

Y

yield coefficient

α,β

coefficients of interface heat and mass transfer

ρ

density

μ

viscosity

σ

surface tension

Laplace operator

Δ

difference operator

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Copyright information

© Folia Microbiologica 1992

Authors and Affiliations

  • J. Votruba
    • 1
  • M. Sobotka
    • 1
  1. 1.Institute of MicrobiologyCzechoslovak Academy of SciencesPrague 4

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