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Streptomycetes producing daunomycin and related compounds: Do we know enough about them after 25 years?

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Abstract

The growing need of highly potent anticancer agents has stimulated the investigation of streptomycetes producing daunomycin-type anthracyclines. This review compares the features of production strains and their mutants and emphasizes the necessity of application of biochemical and biophysical analytical methods for better understanding these microorganisms and, above all, their further improving and practical usage.

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Abbreviations

DM:

daunomycin

AM:

adriamycin

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Authors and Affiliations

  1. Research Institute of Antibiotics and Biotransformations, 252 63, Roztoky near Prague

    J. Huk & M. Blumauerova

  2. Institute of Microbiology, Czechoslovak Academy of Sciences, 142 20, Prague 4

    J. Huk & M. Blumauerova

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  1. J. Huk
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  2. M. Blumauerova
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Huk, J., Blumauerova, M. Streptomycetes producing daunomycin and related compounds: Do we know enough about them after 25 years?. Folia Microbiol 34, 324–349 (1989). https://doi.org/10.1007/BF02814475

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