Candida-associated denture stomatitis

Abstract

Candida-associated denture stomatitis was demonstrated by its cultivation in 171 out of 240 patients examined with partial or total dentures. After taking smears from lesions of the oral mucosa (tongue, cheeks, palate) and the contiguous denture surface by cotton wool swabs and inoculating them onto Sabouraud glucose agar and CHROMagarCandida, individual yeast species were identified by a germ tube. filamentous, and assimilation tests employing the commercial kit AuxaColor. SevenCandida species were identified in smears from the oral mucosa lesions and the contiguous denture surface:C. albicans (95 patients),C. tropicalis (26).C. parapsilosis (20),C. krusei (14),C. guilliermondii (12),C. lusitaniae (1) andC. freyschusii (1). Diabetes mellitus, neoplastic diseases, chemotherapy, radiotherapy, and broad-spectrum antibiotic therapy were identified as some of the large number of factors predisposing patients to stomatitis prothetica.

This is a preview of subscription content, access via your institution.

References

  1. Allen C.A.: Diagnosing and managing oral candidiasis.J. Am. Dental Assoc.123, 77–82 (1992).

    CAS  Google Scholar 

  2. Bendel C.M., Sauver, J., Carlson S., Hostetter M.K.: Epithelial adhesion in yeast species: correlation with surface expression of the integrin analog.J. Infect. Dis.171, 1660–1663 (1995).

    PubMed  CAS  Google Scholar 

  3. Budtz-Jørgensen E.: Etiology, pathogenesis, therapy, and prophylaxis oral yeast infectios.Acta Odontol. Scand.48, 61–69 (1990).

    PubMed  Article  Google Scholar 

  4. Budtz-Jørgensen E., Mojon P., Banon-Clément J.M., Baehni P.: Oral candidosis in long-term hospital care: comparison of edentulous and dentase subjects.Oral Dis.2, 285–290 (1996).

    Article  Google Scholar 

  5. Dedic A., Masic I.: Diabetes mellitus andCandida albicans.Med. Arh.53, 43–45 (1999).

    PubMed  CAS  Google Scholar 

  6. Dorko E., Ďurovićová J.: Possibilities of laboratory diagnosis of oral candidosis.Stomatológ7, 5–7 (1997).

    Google Scholar 

  7. Dorko E., Kmeťová M., Pilipčinec E., Bračoková I., Dorko F., Danko J., Švický E., Tkáčiková Ĺ.: Rare non-albicans Candida species detected in different clinical diagnoses.Folia Microbiol.45, 364–368 (2000a).

    CAS  Google Scholar 

  8. Dorko E., Kmeťová M., Dorko F., Bračoková I., Danko J., Švický E.:Cryptococcus neoformans in clinical specimens.Folia Microbiol.45, 369–372 (2000b).

    CAS  Google Scholar 

  9. Egusa H., Ellepola A.N., Nikawa H., Hamada T., Samaranayake L.P.: Exposure to subtherapeutic concentrations of polyene antifungals suppresses the adherence ofCandida species to denture acrylic.Chemotherapy46, 267–274 (2000).

    PubMed  Article  CAS  Google Scholar 

  10. Ellepola A.N., Samaranayake L.P.: Adhesion of oralCandida albicans isolates to denture acrylic following limited exposure to antifungal agents.Arch. Oral Biol.43, 999–1007 (1998).

    PubMed  Article  CAS  Google Scholar 

  11. Guggenheimer J., Moore P.A., Rossie K., Myers D., Mongelluzzo M.B., Block H.M., Weyant R., Orchard T.: Insulin-dependent diabetes mellitus and oral soft tissue pathologies—II. Prevalence and characteristics ofCandida and candidal lesions.Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.89, 570–576 (2000).

    PubMed  Article  CAS  Google Scholar 

  12. Iacopino A. M., Wathen W.F.: Oral candidal infection and denture stomatitis: a comprehensive review.J. Am. Dental Assoc.123, 46–51 (1992).

    CAS  Google Scholar 

  13. Jeganathan S., Lin C.C.: Denture stomatitis—a review of the etiology, diagnosis and management.Austral. Dent. J.37, 107–114 (1992).

    CAS  Google Scholar 

  14. Kuc I.M., Samaranayake L.P., van Heyst E.N.: Oral health and microflora in an institutionalised elderly population in Canada.Internat. Dent. J.49, 33–40 (1999).

    CAS  Google Scholar 

  15. Lockhart S.R., Joly S., Vargas K., Swails-Wenger J., Enger L., Soll D.R.: Natural defenses againstCandida colonization breakdown in the oral cavities of the elderly.J. Dent. Res.78, 857–868 (1999).

    PubMed  CAS  Google Scholar 

  16. Martin-Mazuelos E., Aller A.I., Romero M.J., Rodriguez-Armijo A., Gutierrez M.J., Bernal S., Montero O.: Response to fluconazole and itraconazole ofCandida spp. in denture stomatitis.Mycoses40, 283–289 (1997).

    PubMed  CAS  Article  Google Scholar 

  17. McMullan-Vogel C.G., Jude H.D., Ollert M.W., Vogel C.W.: Serotype distribution and secretory acid proteinase activity ofCandida albicans isolated from the oral mucosa of patients with denture stomatitis.Oral Microbiol. Immunol.14, 183–189 (1999).

    PubMed  Article  CAS  Google Scholar 

  18. Mucke R., Kaben U., Libera T., Knauerhase H., Ziegler P.G., Hamann D., Strietzel M.: Use of fluconazole as antimycotic prophylaxis in radiotherapy of patients with head and neck tumors.Mycoses40, 53–55 (1997).

    PubMed  Article  Google Scholar 

  19. Mucke R., Kaben U., Libera T., Knauerhase H., Ziegler P.G., Hamann D., Strietzel M.: Fluconazole prophylaxis in patients with head and neck tumors undergoing radiation and radiochemotherapy.Mycoses41, 421–423 (1998).

    PubMed  CAS  Google Scholar 

  20. Nikawa H., Nishimura H., Hamada T., Sadomori S.: Quantification of thigmotropism (contact sensing) ofCandida albicans andCandida tropicalis.Mycopathologia138, 13–19 (1997).

    PubMed  Article  CAS  Google Scholar 

  21. Oksala E.: Factors predisposing to oral yeast infections.Acta Odontol. Scand.48, 71–74 (1990).

    PubMed  Article  CAS  Google Scholar 

  22. Panagoda G.J., Samaranayake L.P.: The relationship between the cell length, adhesion to acrylic and relative cell surface hydrophobicity ofCandida parapsilosis.Med. Mycol.36, 373–378 (1998).

    PubMed  Article  CAS  Google Scholar 

  23. Samaranayake Y.H., Wu P.C., Samaranayake L.P., So M., Yuen K.Y.: Adhesion and colonization ofCandida krusei on host surfaces.J. Med. Microbiol.41, 250–258 (1994).

    PubMed  CAS  Google Scholar 

  24. Tomamoto M., Miyake Y., Fugita Y., Suginaka M., Hamada T.: Frequency and distribution ofCandida species from denture wearers.Hiroshima J. Med. Sci.35, 39–43 (1986).

    Google Scholar 

  25. Vitkov L., Weitgasser R., Lugstein A., Noack M.J., Fuchs K., Krautgartner W.D.: Glycemic disorders in denture stomatitis.J. Oral Pathol. Med.28, 406–409 (1999).

    PubMed  CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to E. Dorko.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Dorko, E., Jenča, A., Pilipčinec, E. et al. Candida-associated denture stomatitis. Folia Microbiol 46, 443–446 (2001). https://doi.org/10.1007/BF02814436

Download citation

Keywords

  • Oral Mucosa
  • Candida Species
  • Germ Tube
  • Oral Mucosa Lesion
  • Assimilation Test