Abstract
Biological properties of new copper(II) complexes of 2-methylthionicotinate (2-MeSNic) of composition Cu(2-MeSNic)2(MeNia)2·4H2O (where MeNia isN-methylnicotinamide), Cu(2-MeSNic)2(Nia)2·2H2O (where Nia is nicotinamide) and Cu(2-MeSNic)2(2 (where L is isonicotinamide (iNia) or ethyl nicotinate (EtNic)) are reported. Gram−-bacteria (Escherichia coli) are more resistant against Cu(II) complexes than Gram+-bacteria (Staphylococcus aureus)—significant antistaphylococcal activity was found with Cu(2-MeSNic)2(MeNia)2·4H2O (IC50 1.3 mmol/L).Caddida parapsilosis was most inhibited by Cu(2-MeSNic)2·H2O and Cu(2-MeSNic)2(MeNia)2·4H2O (IC50 1.4 mmol/L and 1.5 mmol/L, respectively). Biosynthesis of nucleic acids influenced by Cu(2-MeSNic)2-(Nia)2·2H2O indicated by incorporation of14C-adenine (IC50(Ade) 0.31 mmol/L) is more sensitive than biosynthesis of proteins indicated by incorporation of14C-leucine (IC50(Leu) 9.94 mmol/L). Cu(II) complexes with expressed antimicrobial activity showed no mutagenic activity.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bencko V., Cikrt M., Lener J.:Toxic Metals in the Human Environment, 2th ed. Grada Publishing Prague 1996.
Bláhová M., Lahitová N., Sokolík J.: Mutagenic activity of (2-chlorophenoxyacetato)copper(II) complexes with 4-nitrosubstituted heteroaromaticN-oxides.Čes. Slov. Farm.47, 215–219 (1998).
Gabriel J., Shah V., Nesmêrák K., Baldrian P., Nerud F.: Degradation of polycyclic aromatic hydrocarbons by the copper(II)-hydrogen peroxide system.Folia Microbiol.45, 573–575 (2000).
Gombošová I., Valentová J., Sokolík J., Žemliĉka M., Švec P.: Radioprotective effects of some basic carboxylatocopper(II) complexes.Ĉes. Slov. Farm.43, 237–239 (1994).
Hudecová D., Jantová S., Melník M., Uher M.: New azidometalkojates and their biological activity.Folia Microbiol.41, 473–476 (1996).
Jantová S., Labuda V., Vollek V., Zastková M.: Antimicrobial effects of the macrocyclic Cu(II)-tetraanhydroaminobenzaldehyde complex.Folia Microbiol.42, 324–326 (1997).
Jantová S., Ďuračková Z., Novotný L., Urbančíková M., Dovinová I., Labuda J., Wsolová L.: Macrocyclic Cu(II) tetraanhydroaminobenzaldehyde complex—antiproliferative activityin vitro andin vivo.Neoplasma45, 254–260 (1998).
Majtán V., Majtánová L’.: Effect of quaternary ammonium salts on energy-yielding and energy-requiring processes inSalmonella typhimurium.Drug Res.45, 1021–1023 (1995).
Maron D., Ames B.N.: Revised methods for theSalmonella mutagenicity test.Mutat. Res.113, 173–215 (1983).
Mikloŝ D., Segl’a P., Palicová M., Kopcová M., Melník M., Valko M., Glowiak T., Korabik M., Mrozinski J.: Synthesis spectral and magnetic properties, and crystal structures of copper(II) 2-methylthionicotinate adducts with chelating ligands.Polyhedron20, 1867–1874 (2001).
Miko M., Devínsky F.:In vitro cytotoxic activity of 1-alkylpiperidineN-oxides and quantitative structure-activity relationships.Anti-Cancer Drugs4, 471–478 (1993).
Segl’a P., Palicová M., Koman M., Mikloŝ D., Melník M.: Synthesis, spectral properties and crystal structures of copper(II) isonicotinates, first example of uncoordinated isonicotinates.Inorg. Chem. Commun.3, 120–125 (1999).
Sokolík J., T⫲mová I., Blahová M., Harisová E., Ŝvec P.: Antiedematous activity of selected arylcarboxylatocopper(II) aquacomplexes.Čes. Slov. Farm.47, 91–94 (1998).
Sorenson J.R.J., Oberley L.W., Crouch R.K., Kensler T.W.: Pharmacological activities of SOD-like copper complexes, pp. 821–831 in W. Boors, M. Saran, D. Tait, W. de Gruyter (Eds):Oxygen Radicals in Chemistry and Biology. Springer-Verlag, Berlin-New York 1984.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Dudová, B., Hudecová, D., Pokorný, R. et al. Copper complexes with bioactive ligands. Folia Microbiol 46, 379–384 (2001). https://doi.org/10.1007/BF02814425
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02814425