Abstract
High concentrations of long-chain fatty acids have been found to be harmful to mammalian cells and prokaryotic organisms. This effect was investigated in Saccharomyces cerevisiae. Addition of 3 mmol/L palmitate to a yeast extract-peptone medium caused a significant inhibition of cell growth during the first 2 d of incubation, followed by renewed growth and palmitate utilization. Inhibition was also observed with palmitate concentrations down to 0.1 mmol/L. As inferred from catalase activity determinations, this effect was found to correlate with the absence of peroxisome proliferation. Finally, no inhibition was observed in exponential-phase cultures or in the presence of 0.1 g/L glucose, this suggesting that the physiological state of the cell may determine whether its growth will be inhibited by fatty acids.
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Dell'angelica, E.C., Stella, C.A., Ermácora, M.R. et al. Inhibitory action of palmitic acid on the growth ofSaccharomyces cerevisiae . Folia Microbiol 38, 486–490 (1993). https://doi.org/10.1007/BF02814400
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DOI: https://doi.org/10.1007/BF02814400