Skip to main content

Advertisement

Log in

A case of focal nodular hyperplasia of the liver

  • Case Report
  • Published:
Gastroenterologia Japonica Aims and scope Submit manuscript

Summary

Focal nodular hyperplasia of the liver is a rare benign tumor of unknown etiology. Presented here is a case of focal nodular hyperplasia of the liver in a 19-year-old man with asymptomatic hepatomegaly. Liver scan and selective hepatic angiography revealed a tumor mass, which was indistinguishable from a malignant tumor. At laparotomy a large mass measured 16 x 10 x 4 cm and weighed 480 gm arising from a part of the left hepatic lobe and extending down to the abdominal cavity was found. The gross and microscopic findings established the diagnosis of focal nodular hyperplasia of the liver. The clinical, radiological and pathological findings in the patient are described in detail.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Evans JE, et al: Focal nodular hyperplasia of the liver. Br J Surg 67: 175, 1980

    Article  PubMed  CAS  Google Scholar 

  2. Knowles DM, Wolff M: Focal nodular hyperplasia of the liver: a clinicopathologic study and review of the literature. Human Pathol 7: 533, 1976

    Article  CAS  Google Scholar 

  3. Edmondson HA: Differential diagnosis of tumors and tumor-like lesions of liver in infancy and childhood. Am J Dis Child 91: 168, 1956

    CAS  Google Scholar 

  4. Steiner PE: Nodular regenerative hyperplasia of the liver. Am J Pathol 35: 943, 1959

    PubMed  CAS  Google Scholar 

  5. Blendis LM, et al: Nodular regenerative hyperplasia of the liver in Felty’s syndrome. Quart J Med 43: 25, 1974

    PubMed  CAS  Google Scholar 

  6. Knowles DM, et al: Nodular regenerative hyperplasia of the liver. Gastroenterology 69: 746, 1975

    PubMed  Google Scholar 

  7. Shorey J, et al: Nodular regenerative hyperplasia of the liver on a case of myelofibrosis with extramedullary hematopoiesis and secondary portal hypertension. Am J Clin Pathol 72: 122, 1979

    PubMed  CAS  Google Scholar 

  8. Shedlofsky S, et al: Noncirrhotic nodular transformation of the liver with portal hypertension: clinical, angiographic, and pathological correlation. Gastroenterology 79: 938, 1980

    PubMed  CAS  Google Scholar 

  9. Ishak KG, Rabin L: Benign tumors of the liver. Med Clin North Am 59: 995, 1975

    PubMed  CAS  Google Scholar 

  10. Fechner RE: Benign hepatic lesions and orally administered contraceptives: a report of seven cases and a critical analysis of the literature. Human Pathol 8: 255, 1977

    Article  CAS  Google Scholar 

  11. Begg CF, Berry WH: Isolated nodules of regenerative hyperplasia of the liver. Am J Clin Pathol 23: 447, 1953

    PubMed  CAS  Google Scholar 

  12. Franklin CRG, Bowning LCF: Primary liver tumors. Am J Surg 73: 390, 1947

    Article  Google Scholar 

  13. Gerding WJ, et al: Hamartomatous cholangiohepatoma: report of a case. JAM A 145: 821, 1951

    CAS  Google Scholar 

  14. Clay RC, Finney GG: Lobectomy of the liver for benign conditions. Ann Surg 147: 827, 1958

    PubMed  CAS  Google Scholar 

  15. Mays ET, et al: Focal nodular hyperplasia of the liver: possible relationship to oral contraceptives. Am J Clin Pathol 61: 735, 1974

    PubMed  CAS  Google Scholar 

  16. Klatskin G: Hepatic tumors: possible relationship to use of oral contraceptives. Gastroenterology 73: 386, 1977

    PubMed  CAS  Google Scholar 

  17. McAvoy JM, et al: Benign hepatic tumors and their association with oral contraceptives. Arch Surg 3: 761, 1976

    Google Scholar 

  18. Bartók I, et al: Focal nodular hyperplasia of the liver and hepatic cell adenoma in woman on oral contraceptives. Hepato-Gastroenterology 27: 435, 1980

    PubMed  Google Scholar 

  19. Davis M, et al: Histological evidence of carcinoma in a hepatic tumor associated with oral contraceptives. Br Med J4:496, 1975

    Article  PubMed  CAS  Google Scholar 

  20. Malt RA, et al: Experience with benign tumors of the liver. Surg Gynec Obstet 130: 285, 1970

    PubMed  CAS  Google Scholar 

  21. Whelan TJ, et al: Focal nodular hyperplasia of the liver. Ann Surg 177: 150, 1973

    Article  PubMed  Google Scholar 

  22. Ueda T, et al: A case of focal nodular hyperplasia of the liver mistaken for hepatocellular carcinoma. Jpn J Pediat Surg Med 2: 333, 1970

    Google Scholar 

  23. Ueda S, et al: Focal nodular hyperplasia of the liver followed for 15 years after right hepatic lobectomy: a case report. Jpn J Pediat Surg 10: 119, 1974

    Google Scholar 

  24. Tanaka S, et al: A case of relatively small focal nodular hyperplasia of the liver. Adult Dis 20: 29, 1979

    Google Scholar 

  25. Hirohashi K, et al: A case of giant focal nodular hyperplasia of the liver in young male. Acta Hepatol Jpn 20: 868, 1979

    Google Scholar 

  26. Fujii S, et al: A case of focal nodular hyperplasia of the liver associated with female sex hormone treatment. Acta Hepatol Jpn 19: 571, 1978

    Google Scholar 

  27. Kato K, et al: A case of focal nodular hyperplasia of the liver in the young male with gonadal dysfunction. Acta Hepatol Jpn 22: 292, 1981

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hirata, T., Koga, S., Ibayashi, H. et al. A case of focal nodular hyperplasia of the liver. Gastroenterol Jpn 16, 604–610 (1981). https://doi.org/10.1007/BF02813796

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02813796

Key Words

Navigation