Summary
The relationship between the prognosis of the disease based on liver histology and HB virus (HBV) associated antigen/antibody systems was investigated in twenty seven patients with chronic active hepatitis (CAH). These patients were followed up over extended periods with mean duration of 44.3 months. On initial liver biopsy five of twelve patients with CAH with spotty or focal necrosis were HBs antigen (HBsAg) positive, as were also five of six patients with sublobular necrosis and six of nine patients with lobular disorganization. Most of the HBsAg negative patients were anti-HBs or anti-HBc positive: HBV associated antigen or antibody was completely undetectable in only three of the twenty seven patients. There was no difference in the frequency of progression to liver cirrhosis (LC) between the sixteen HBsAg positive and the eleven HBsAg negative patients with CAH. On the other hand, progression to LC occurred in only one of seven HBe antigen (HBeAg) negative patients, compared to four of nine HBeAg positive patients, who were HBsAg positive. There were four patients who were HBeAg positive initially but then became HBeAg negative in the course of observation. LC developed in two of these four patients.
These results suggest that in HBsAg positive patients with CAH the presence or absence of HBeAg and the variation in its level can provide useful indicators of the prognosis of the disease.
Similar content being viewed by others
References
Sherlock S: Chronic hepatitis, in “Diseases of the Liver and Biliary System” 5th Ed Blackwell Scientific Publications, London, 1975, p 425
Rakala J, et al: Hepatitis A virus infection in fulminant and chronic active hepatitis. Gastroenterology 74: 879, 1978
Hoofnagle JH, et al: Transmission of non-A, non-B hepatitis. Ann Intern Med 87: 14, 1977
Zuckerman AJ: The epidemiology of viral hepatitis, in “Human Viral Hepatitis” 2nd Ed North-Holland Publishing Company, New York, 1975, p 33
De Groote J, et al: Long-term follow-up of chronic active hepatitis of moderate severity. Gut 19: 510, 1978
Schalm SW, et al: Contrasting features and responses to treatment of chronic active liver diseases with and without hepatitis Bs antigen. Gut 17: 781, 1976
Chadwick RG, et al: Chronic persistent hepatitis: hepatitis B virus markers and histological follow-up. Gut 20: 372, 1979
Harada T, et al: Panel discussion (2): Prognosis of chronic liver diseases. Gastroenterol Jpn 14: 640, 1979
De Groote, et al: A classification of chronic hepatitis. Lancet 2: 626, 1968
Leevy CM, et al: Chronic hepatitis, in “Diseases of the Liver and Biliary Tract: Standarization of Nomenclature, Diagnostic Criteria and Diagnostic Methodology” Castle House Publication Ltd, London p 9, 1979
Boyer JL, et al: Pattern of necrosis in acute viral hepatitis. Prognostic value of bridging (Subacute hepatic necrosis). New Engl J Med 283: 1063, 1970
Schalm SW, et al: Severe chronic active liver disease, prognostic significance of initial morphologic patterns. Am J Dis 22: 973, 1977
Baggenstoss AH, et al: Chronic active liver disease, the range of histological lesions, their response to treatment, and evolution. Human Pathol 3: 183, 1972
Kosaka Y, et al: Prognostic evaluation of chronic hepatitis with particular reference to the findings of repeated liver biopsy. Jpn J Gastroent 78: 667, 1981
Giusti G, et al: Treatment of chronic active hepatitis with either prednisolone or corticotrophin. Acta Hepatogastroenterol 24: 131, 1977
Jorge AD, et al: Therapeutic evaluation of chronic aggressive hepatitis and its relation to the Australia antigen. Acta Hepatogastroenterol 25: 179, 1978
Christoffersen P, et al: Histological changes on liver biopsies from patients with chronic hepatitis. Acta Pathol Microbiol Scand, Sec A 82: 539, 1974
Magnius LO, et al: New specificies in Australia antigen positive sera distinct from the LeBouvier determinants. J Immunol 109: 1017, 1972
Furuta S, et al: Clinical significance of e-antigen/antibody, with special reference to HBc antigen in the liver. GastroenteroI Jpn 12: 460, 1977
Sheikh NEL, et al: e Antigen-antibody system as indicator of liver damage in patients with hepatitis-B antigen. Brit Med J 4: 252, 1975
Hess G, et al: e-System and intrahepatocellular HBcAg and HBsAg in HBsAg positive patients with liver diseases and healthy carriers. Scand J Gastroenterol 12: 325, 1977
Fay O, et al: Prognostic implications of the e antigen of hepatitis B virus. JAMA 238: 2501, 1977
Realdi G, et al: Seroconversion from hepatitis Be antigen to anti-HBe in chronic hepatitis. Gastroenterology 79: 195, 1980
Vogten AJM: Behaviour of e antigen and antibody during chronic active liver disease relation to HB antigen-antibody system and prognosis. Lancet 2: 126, 1977
Nordenfelt E, et al: Dane particle-associated DNA polymerase and e antigen: relation to chronic hepatitis among carriers of hepatitis B surface antigen. Eur J Inf Dis 134:85, 1976
Niermeijer P, et al: Hepatitis B antigen and antibodies in chronic hepatitis. New Engl J Med 231: 269, 1979
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kosaka, Y., Tameda, Y., Okuda, Y. et al. A study on the relationship between the prognosis of chronic active hepatitis and the HBV associated antigen/antibody systems. Gastroenterol Jpn 16, 592–599 (1981). https://doi.org/10.1007/BF02813794
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02813794