Summary
Liver specimens were obtained from 21 non-A, non-B hepatitis patients when their surum transaminase levels were still elevated. The specimens were investigated by transmission electron microscope in order to investigate the presence of the structures relating to this type of hepatitis. Intranuclear electron-dense aggregates of virus-like particles were observed in 2 out of 21 cases. One was an unresolved acute hepatitis case with short-incubation posttransfusion type, and the other was a chronic persistent hepatitis case without blood-transfusion. The size of these particles varied from 22 to 28 nm in diameter. The incidence of hepatocytes with the particles was approximately 2 to 3% of the cells investigated. These particles may represent an intranuclear alteration in close association with one type of non-A, non-B hepatitis.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Alter HJ, et al: Transmissible agent in non-A, non-B hepatitis. Lancet 1: 459, 1978
Tabor E, et al: Transmission of non-A, non-B hepatitis from man to chimpanzee. Lancet 1: 463, 1978
Hollinger FB, et al: Non-A, non-B hepatitis transmission in chimpanzees: A project of the transfusiontransmitted viruses study group. Intervirology 10: 60, 1978
Wyke RJ, et al: Transmission of non-A, non-B hepatitis to chimpanzees by factor IX concentrates after fatal complications on patients with chronic liver disease. Lancet 1: 520, 1979
Knodell RG, et al: Etiological spectrum of post-transfusion hepatitis. Gastroenterology 69: 1278, 1975
Purcell RH, et al: Non-A, non-B hepatitis. Yale J Biol Med 49:243, 1976
Mosley JW, et al: Multiple hepatitis viruses in multiple attacks of acute viral hepatitis. N Engl J Med 296: 75, 1977
Tsiquaye KN, Zuckerman AJ: New human hepatitis virus. Lancet 1: 1135, 1979
Galbraith RM, et al: Non-A, non-B hepatitis associated with chronic liver diseases in a haemodialysis unit. Lancet 1:951, 1979
Jackson D, et al: Acute non-A, non-B hepatitis: Specific ultrastructural alterations in endoplasmic reticulum of infected hepatocytes. Lancet 1: 1249, 1979
Shimizu YK, et al: Non-A, non-B hepatitis: Ultrastructural evidence for two agents in experimentally infected chimpanzees. Science 205: 197, 1979
Tsiquaye KN, et al: Further evidence of cellular changes associated with non-A, non-B hepatitis. J Med Virol 5: 63, 1980
Bradley EW, et al: Experimental infection of chimpanzees with antihemophilic (Factor VIII) materials: Recovery of virus-like particles associated with non-A, non-B hepatitis. J Med Virol 3: 253, 1979
Yoshizawa H, et al: Virus-like particles in a plasma fraction (fibrinogen) and in the circulation of apparently healthy blood donors capable of inducing nonA/nonB hepatitis in human and chimpanzees. Gastroenterology 79: 512, 1980
Hantz O, et al: non.A, non-B hepatitis: Identification of hepatitis-B-like virus particles in serum and liver. J Med Virol 5: 73, 1980
Gmerin K, et al: Intranuclear virus-like particles in a case of sporadic non-A, non-B hepatitis. J Med Virol 5:317, 1980
Grimaud JA, et al: Hepatic intranuclear particles in patients with non-A, non-B hepatitis. N Engl J Med 303: 818, 1980
Wolf-Peeters CD, et al: Human non-A, non-B hepatitis: ultrastructural alteration on hepatocytes. Liver 1: 50, 1981
Author information
Authors and Affiliations
Additional information
This study was supported in part by a grant from the Ministry of Health and Welfare of Japan.
Rights and permissions
About this article
Cite this article
Gibo, Y., Nagata, A., Kiyosawa, K. et al. Intranuclear virus-like particles in the hepatocytes of the patients with non-A, non-B hepatitis. Gastroenterol Jpn 16, 576–581 (1981). https://doi.org/10.1007/BF02813792
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02813792