Summary
The clinical profile of extrapyramidal manifestations following chloroquine therapy for the treatment of malaria in 4 children is described. The characteristic features included upward rolilng of the eyeballs, trismus, torticollis and bizarve writhing torsion dystonia of the limbs. The effect appears to be dose-related rather than idiosyncratic and is self limited because spontaneous recovery occurred in all patients within 48 hours.
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From the Department of Paediatrics, All-India Institute of Medical Sciences, New Delhi-110016
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Singhi, S., Singhi, P. & Singh, M. Extrapyrbmidal syndrome following chloroquine therapy. Indian J Pediatr 46, 58–60 (1979). https://doi.org/10.1007/BF02811499
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DOI: https://doi.org/10.1007/BF02811499