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Hepatocellular carcinoma: Efficacy of transcatheter oily chemoembolization in relation to macroscopic and microscopic patterns of tumor growth among 100 patients with partial hepatectomy

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Abstract

Purpose: To evaluate the efficacy of transcatheter oily chemoembolization (TOCE) for hepatoceliular carcinoma (HCC) on the basis of microscopic and macroscopic findings postembolization.

Methods: HCCs ranging in size from 0.5 to 13 cm (mean 3.6 cm) were obtained from partial hepatectomies of 100 consecutive patients who had undergone TOCE between 20 and 246 days (mean 59.5 days) prior to surgery. The efficacy of TOCE was assessed on the basis of the necrotic to live cell ratio of the tumors. The microscopic pattern of tumor growth was grouped into expanding type (complete capsule formation) and replacing type (incomplete or no capsule). There were five types of macroscopic groupings: single nodule, single nodule with extranodular growth (SNE), contiguous and noncontiguous multinodular, and massive growth type.

Results: Among 79 cases with the expanding type, 29 (37%) had 100% HCC necrosis, but none with 100% necrosis were in the replacing type. By macroscopic grouping, the efficacy of TOCE decreased from the single nodule type (50% of patients had 100% necrosis) to the SNE type (21%), and the other types (9%).

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Authors and Affiliations

  1. Department of Radiology, Osaka University Medical School, 2-2 Yamadaoka, Suita-shi, 565, Osaka, Japan

    Tohru Hashimoto M.D., Hironobu Nakamura, Shinichi Hori, Kaname Tomoda, Katsuyuki Nakanishi, Takamichi Murakami & Takahiro Kozuka

  2. Department of Second Surgery, Osaka University Medical School, 2-2 Yamadaoka, Suita-shi, 565, Osaka, Japan

    Morito Monden & Mitsukazu Gotoh

  3. Department of Diagnostic Radiology, Osaka Adult Disease Center, 1-3-3 Nakamichi, Higashinari-ku, 537, Osaka, Japan

    Chikazumi Kuroda

  4. Department of Pathology, Osaka City University Medical School, 1-5-7 Asahimachi, Abeno-ku, 545, Osaka, Japan

    Kenichi Wakasa & Masami Sakurai

Authors
  1. Tohru Hashimoto M.D.
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  2. Hironobu Nakamura
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  3. Shinichi Hori
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  4. Kaname Tomoda
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  5. Katsuyuki Nakanishi
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  6. Takamichi Murakami
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  7. Takahiro Kozuka
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  8. Morito Monden
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  9. Mitsukazu Gotoh
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  10. Chikazumi Kuroda
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  11. Kenichi Wakasa
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  12. Masami Sakurai
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Hashimoto, T., Nakamura, H., Hori, S. et al. Hepatocellular carcinoma: Efficacy of transcatheter oily chemoembolization in relation to macroscopic and microscopic patterns of tumor growth among 100 patients with partial hepatectomy. Cardiovasc Intervent Radiol 18, 82–86 (1995). https://doi.org/10.1007/BF02807227

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