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Urinary concentrations of bile acid glucuronides and sulfates in hepatobiliary diseases

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Summary

Urinary bile acids in normal subjects and patients with obstructive jaundice and liver cirrhosis were quantitated by mass fragmentography after separation into nonglucuronidated-nonsulfated, glucuronidated and sulfated fractions. Mean values of total bile acids in urine were as follows: Control subjects (n=7), 1.90 ±0.67; obstructive jaundice (n=9), 77.90 ±40.39; liver cirrhosis, compensated (n=6), 15.14 ±8.97, and decompensated (n=6), 11.84 ±9.32 (mean ±SD, mg/day). The percentages of each conjugate was 19–29% in the non glucuronidated-nonsulfated fraction, 6–14% in the glucuronidated fraction and 60–74% in the sulfated frac tion. Bile acids in urine and serum correlated well in each fraction (r=0.82-0.84, p<0.001). The clearance of the three conjugates was the highest in the sulfates, and the clearance of glucuronides was higher than that of non-esterified bile acids. The glucuronidation and sulfation of bile acids play an important role in the detoxication of bile acids by excreting them into urine, especially in patients with elevated serum bile acids.

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Authors and Affiliations

  1. 2nd Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyoku, 113, Tokyo, Japan

    Hajime Takikawa M.D.

  2. 2nd Department of Surgery, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, 113, Tokyo, Japan

    Tomoe Beppu M.D.

  3. Department of Physiological Chemistry and Nutrition, Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, 113, Tokyo, Japan

    Yousuke Seyama M.D.

Authors
  1. Hajime Takikawa M.D.
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  2. Tomoe Beppu M.D.
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  3. Yousuke Seyama M.D.
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Additional information

This study was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan (No. 57440062, 58570505).

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Takikawa, H., Beppu, T. & Seyama, Y. Urinary concentrations of bile acid glucuronides and sulfates in hepatobiliary diseases. Gastroenterol Jpn 19, 104–109 (1984). https://doi.org/10.1007/BF02806931

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  • DOI: https://doi.org/10.1007/BF02806931

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