Immunogenicity of plasma-derived Hepatitis B vaccine in preterm infants

Abstract

The objective was to determine whether plasma-derived hepatitis B vaccine is immunogenic in preterm appropriate for gestation babies when administered at birth and to compare the immunogenicity between 5 μg and 10 μg doses of the vaccine in these babies.

Fifty preterm neonates (31-36 weeks gestation) were randomized to receive 5 μg or 10 μg doses of plasma-derived hepatitis B vaccine at birth, with subsequent doses 1 and 6 months later. Serum specimens were obtained a month after each dose of the vaccine and were tested for antibody to hepatitis B surface antigen (anti-HBs).

Thirty six babies (gestation 31–36 weeks), 18 from each group competed the study. While 89.2% of the babies seroconverted, 82. 1% achieved seroprotective titres of anti-HBS (> 10 mlU/ml). There was no difference between weight, gestational age, age of administration of vaccine and age of estimation of anti-HBs between 5 μg and 10 μg groups. The difference in the seroprotective rates were not statistically different between the groups (5 μg 78.5%; 10 μg-85.7%).

Although immune response to plasma derived hepatitis B vaccine in preterm babies is suboptimal when the first dose is administered at birth, the full course achieves adequate seroprotective levels.