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Anaphylactoid reactions to narcotic analgesics

  • Anesthesiology and Allergy
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Conclusion

Athough reports in the literature of severe anaphylactic reactions to narcotics are rare, they occur, and it may be that such reactions are true IgE-mediated reactions, rather than direct histamine release as has been previously believed. Cross-sensitivity between individual opioid derivative members of the fentanyl group od drugs appears likely.

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Authors and Affiliations

  1. Intensive Therapy Unit, Royal North Shore Hospital of Sydney, 2065, St. Leonards, NSW

    Malcolm M. Fisher

  2. Department of Anaesthesia, University of Sydney, Australia

    Malcolm M. Fisher

  3. Kolling Institute of Medical Research, Royal North Shore Hospital, Australia

    David G. Harle & Brian A. Baldo

  4. Department of Medicine, University of Sydney, Sydney, Australia

    David G. Harle & Brian A. Baldo

Authors
  1. Malcolm M. Fisher
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  2. David G. Harle
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  3. Brian A. Baldo
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Fisher, M.M., Harle, D.G. & Baldo, B.A. Anaphylactoid reactions to narcotic analgesics. Clinical Reviews in Allergy 9, 309–318 (1991). https://doi.org/10.1007/BF02802310

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