Skip to main content
SpringerLink
Log in

Loratadine

A review of recent findings in pharmacology, pharmacokinetics, efficacy, and safety, with a look at its use in combination with pseudoephedrine

  • Published:
Clinical Reviews in Allergy Aims and scope Submit manuscript

Summary

Antihistamines are considered first-line therapy for the relief of symptoms from allergic rhinitis and chronic urticaria. The newer, second-generation, nonsedating antihistamines reduce the central nervous system and anticholinergic side effects commonly found with previous drugs. The availability of H1 receptor antagonists that produce therapeutic effects without causing unwanted CNS effects fulfills an important practical need, since these drugs are clearly preferable in patients who drive or operate heavy machinery, or who are involved in activities requiring full alertness.

Physicians and patients alike are pleased with the efficacy and safety the second-generation antihistamines bring to the treatment of allergy symptoms. Loratadine is an especially effective second-generation H1-receptor antagonist and is comparable to many of the other second-generation antihistamines. Loratadine may be particularly advantageous because of its low dose and the convenience of once-daily dosing. A more subtle advantage, loratadine’s antiallergic properties, may warrant its use for specific treatment situations as future research clarifies the nature of the inflammatory response and the mechanisms of action antiallergic antagonists have in this regard.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Friedman, H. M. (1987),Am. J. Rhino. 1(2), 95–99.

    Article  Google Scholar 

  2. Simons, F. E. R. (1990),J. Allergy Clin. Immunol. 84, 845–861.

    Article  Google Scholar 

  3. Simons, F. E. R. (1990),J. Allergy Clin. Immunol. 86, 995–999.

    Article  PubMed  CAS  Google Scholar 

  4. Holgate, S. T. and Finnerty, J. P. (1989),J. Allergy Clin. Immunol. 83, 537–547.

    Article  PubMed  CAS  Google Scholar 

  5. Woodward, J. K. (1990),J. Allergy Clin. Immunol. 86, 606–612.

    Article  PubMed  CAS  Google Scholar 

  6. Mauser, P. J., Kreutner, W., Egan, R. W., and Chapman, R. W. (1990),Eur. J. Pharmacol. 182, 125–129.

    Article  PubMed  CAS  Google Scholar 

  7. Milazzo, N., Lorini M., and Tedeschi, A. (1992), Presented at the XVth Eur. Cong. of Allergol. and Clin. Immunol., Paris, May 10–15.

  8. Kreutner, W., Chapman, R. W., Gulbenkian, and Siegel, M. I. (1987),Allergy 42, 57–63.

    Article  PubMed  CAS  Google Scholar 

  9. Emery, D. L., Siegel, M. I., Cuss, F. M., Danzig, M. R., Fish, J. E., and Peters, S. P. (1990),)Clin. Exp. Allergy 20, 40.

    Google Scholar 

  10. Patella, V., Casolaro, V., Marchesi, E., and Marone, G. (1992), Presented at XVth Eur. Cong. of Allergol. and Clin. Immunol., Paris, May 10–15.

  11. Bousquet, J., Lebel, B., Chanal, I., Morel, A., and Michel, F. B. (1988),J. Allergy Clin. Immunol. 82, 881–887.

    Article  PubMed  CAS  Google Scholar 

  12. Temple, D. M. and McCluskey, M. (1988),Prostaglandins 35, 549–554.

    Article  PubMed  CAS  Google Scholar 

  13. Berthon, B., Combettes, L., Taudou, G., Czarlewski, W., and Weyer, A. (1992),J. Allergy Clin. Immunol. 89, 355.

    Google Scholar 

  14. Letari, O., Miozzo, A., Sala, A., Bolla, M., Rovati, G. E., and Folco, G. C. (1992), Presented at the XVth Eur. Cong. of Allergol. and Clin. Immunol., Paris, May 10–15.

  15. Cuss, F., Gulbenkian, A., Egan, R., Danzig, M., and Kreutner, W. (1990),Clin. Exp. Allergy 20, 57.

    Google Scholar 

  16. Danzig, M., Bolser, D., Chapman, R., Egan, R., Cuss, F., Kreutner, W., and Siegel, M. (1990),Clin. Exp. Allergy 20, 61.

    Google Scholar 

  17. Cuss, F., Kreutner, W., Danzig, M., Egan, R., and Seigel, M. (1990),Clin. Exp. Allergy 20, 99.

    Article  Google Scholar 

  18. Andersson, M., Nolte, H., Baumgarten, C., and Pipkorn, U. (1991),J. Allergy Clin. Immunol. 87(1), 153.

    Article  Google Scholar 

  19. Baumgarten, C. R., Lernet, M., and Kunkel, G. (1990),J. Allergy Clin. Immunol. 85, 164.

    Google Scholar 

  20. Hammarlund, A., Olsson, P., and Pipkorn, U. (1990),Allergy 45, 64–70.

    Article  PubMed  CAS  Google Scholar 

  21. Buscaglia, S., Ciprandi, G., Marchesi, E., Danzig, M., Cuss, F., and Canonica, G. W. (1992), Presented at the XVth Eur. Cong. of Allergol. and Clin. Immunol., Paris, May 10–15.

  22. Roman, I. J., Kassem, N., Gural, R. P., and Herron, J. (1986),Ann. Allergy 57, 253–256.

    PubMed  CAS  Google Scholar 

  23. Bousquet, J., Chanal, I., Skassa-Brociek, W., Lemonier, C., and Michel, F. B. (1990),J. Allergy Clin. Immunol. 86, 248–253.

    Article  PubMed  CAS  Google Scholar 

  24. Long, W. F., Taylor, R. J., Wagner, C. J., Leavengood, D. C., and Nelson, H. S. (1985),J. Allergy Clin. Immunol. 76(1), 113–117.

    Article  PubMed  CAS  Google Scholar 

  25. Clissold, S. P., Sorkin, E. M., and Goa, K. (1989),Drugs 37, 42–57.

    PubMed  CAS  Google Scholar 

  26. Del Carpio, J., Kabbash, L., Turenne, Y., Prevost, M., Hebert, J., Bedard, P. M., Nedilski, M., and Gutkowski, A. (1989),J. Allergy Clin. Immunol. 84, 741–746.

    Article  PubMed  CAS  Google Scholar 

  27. Frostad, B., Aasand, G., and Sandvik, L. (1991), Presented at Eur. Acad. of Allergol. and Clin. Immunol., Zurich, May 26–29.

  28. Chervinsky, P., Banov, C., Boggs, P., Georgitis, J., and Vanderstouwe, R. (1991), Presented at Eur. Acad. of Allergol. and Clin. Immunol., Zurich, May 26–29.

  29. Boner, L., Miglioranzi, P., Richelli, C., Marchesi, E., and Andreoli, A. (1989),Allergy 44, 437–441.

    Article  PubMed  CAS  Google Scholar 

  30. Molkhou, P., Klose, P., Melon, J., Menardo, J. L., Ronchetti, P., Suonpaa, J., Wahn, U., Wesse, F., Czarlewski, W., Cuss, F., Danzig, M., and Lutsky, B. (1991), Presented at Eur. Acad. of Allergol. and Clin. Immunol., Zurich, May 26–29.

  31. Barnett, A. and Kreutner, W. (1991),New Perspectives in Histamine Research, BirkhÄuser Verlag Basel, 181–196.

    Google Scholar 

  32. Tjwa, M. K. T., Widjaja, F., Delbono, L., Pilcher, W. J., Backhouse, I., and Danzig, M. (1992), Presented at the XVth Eur. Cong. of Allergol. and Clin. Immunol., Paris, May 10–15.

  33. Herman, D., Arnaud, A., Dry, J., Latil, G., Pauli, G., Perrin-Fayolle, M., Vervloet, D., Czarlewski, W., Ménard, G., and Cougnard, J. (1990),Clin. Exp. Allergy 20, 56.

    Article  Google Scholar 

  34. Moote, D. W., Dolovich, J., Mazza, J. A., Clermont, A., Petticlerc, C., and Danzig, M. (1992), Presented at the XVth Eur. Cong. of Allergol. and Clin. Immunol., Paris, May 10–15.

  35. Lockey, R. F. and Fox, R. W. (1989),Immunol. Allergy Pract. 11, 423–429.

    Google Scholar 

  36. FrØlund L., Etholm, B., Irander, K., Johannessen, T., ödkvist, L., Ohlander, B., and Weeke, B. (1990),Allergy 45, 254–261.

    Article  PubMed  Google Scholar 

  37. Bruttmann, G., Charpin, D., Germouty, J., Horak, F., Kunkel, G., and Wittmann, G. (1989),J. Allergy Clin. Immunol. 83, 411–416.

    Article  PubMed  CAS  Google Scholar 

  38. Monroe, E., Fox, R., Kalivas, J., Katz, I., Bernstein D., and Honsinger, R., (1991), Presented at American Acad. of Allergy and Immunol.

  39. Belaich, S., Bruttmann, G., DeGreef, H., Lachapelle, J. M., Paul, E., Pedrali, P., and Tennstedt, D. (1990),Ann. Allergy 64, 191–194.

    PubMed  CAS  Google Scholar 

  40. Hamerlinck, F. F. V., Boyden, B., Oel, H. D., Niordson, A. M., Avrach, W., Ottevanger, V., and Danzig, M. R. (1991), Presented at European Academy of Dermatology and Venereology, Athens, Oct.

  41. Sayag, J., Guillet, G., Leroy, D., Wessel, F., Guillot, B., Moulin, G., Bonerandi, J. J., Amblard, P., Weber, M., Czarlewski, W., LeHalpere, A., and Cougnard, J. (1990)Clin. Exp. Allergy 20, 55.

    Article  Google Scholar 

  42. Guillet, G., Guillet, M., Gavanou, J., Czarlewski, W., and Cougnard, J. (1991), Presented at European Academy of Dermatology and Venereology, Athens, Oct.

  43. Denman, S. T. (1986),J. Am. Acad. of Dermatol. 14(3), 375–392.

    Article  CAS  Google Scholar 

  44. Delawari, E., Czarlewski, W., and Cougnard, J. (1991), Presented at the European Academy of Dermatology and Venereology, Athens, Oct.

  45. Schuller, J. L., Cerio, R., deLourdes Chieira, M., Giannetti, A., Goncalves, H. M., deGroot, L. J., Guillot, B., Vareltzides, A., Herman, P., Cuss, F., Danzig, M., and Lutsky, B. (1991), Presented at Eur. Acad. of Allergol. and Clin. Immunol., Zurich, May 26–29.

  46. Panayiotopoulou, K., Petraki, M., Tapratzi, P., Manoussakis, M., Sinaniotis, C., and Papageorgiou, P. S. (1991), Presented at Eur. Acad. of Allergol. and Clin. Immunol., Zurich, May 26–29.

  47. Glover, D. R., Morris, T., Bryson, S., Hancock, A., and Black, I. (1992), Presented at the XVth Eur. Cong. of Allergol. and Clin. Immunol., Paris, May 10–15.

  48. VanCauwenberge, P. B. (1992),Drug Invest. 4(4), 283–291.

    Google Scholar 

  49. Vuurman, E., Van Veggel, L., Ulterwijk, M., Van Boxtel, M., Leutner, D., and O’Hanlon, J. F. (1992), Presented at the XVth Eu. Cong. of Allergol. and Clin. Immunology, Paris, May 10–15.

  50. Gaillard, A. W. K., Gruisen, A., and de Jong, R. (1988),Eur. J. Clin. Pharmacol. 35, 249–253.

    Article  PubMed  CAS  Google Scholar 

  51. Ramaekers, J., Ulterwijk, M., Cuypers, A., Riedel, W. J., and O’Hanlon, J. F. (1990), Presented at Eur. Acad. of Allergol. and Clin. Immunol., Glasgow, July.

  52. De Roeck, J., Cluydts, R., and, Herman, P. (1990),J. Allergy Clin. Immunol. 85, 179.

    Google Scholar 

  53. Adelsberg, B. R., and D’Amico-Beadon, D. (1990),J. Allergy Clin. Immunol. 85, 296.

    Google Scholar 

  54. Wilkinson, C. and Moskowitz, H. (1989), Presented at 11th International Conference on Alcohol, Drugs and Traffic Safety, Chicago, Oct. 24–27.

  55. Neves Pinto, R. M., Moreira Lima, G., and, da Mota Teixeira, R. (1992),Am. J. Rhinol 6, 23–27.

    Article  Google Scholar 

  56. Grossman, J., Bronsky, E. A., Lanier, B. Q., Linzmayer, M. I., Moss, B. A., Schenkel, E. J., and Seiner, J. C. (1989),Ann. Allergy 63, 317–321.

    PubMed  CAS  Google Scholar 

  57. Simons, F. E. R. (1989),Ann. Allergy 63, 266–268.

    PubMed  CAS  Google Scholar 

  58. Storms, W. W., Bodman, S. F., Nathan, R. A., Chervinsky, P., Banov, C. H., Dockhorn, R. J., Jarmoszuk, I., Zeitz, J., McGeady, J., Pinnas, J. L., and Greenstein, S. M. (1989),J. Allergy Clin. Immunol. 83, 1083–1090.

    Article  PubMed  CAS  Google Scholar 

  59. Berkowitz, R. B., Connell, J. T., Dietz, A. J., Greenstein, S. M., and Tinkelman, D. G. (1989)Ann. Allergy 63 (4), 336–339.

    PubMed  CAS  Google Scholar 

  60. Zeitz, H. J., Jarmoszuk, L., Lanier, B. Q., Storms, W. W., and Greenstein, S. (1992), Presented at the XVth Eur. Cong. of Allergol. and Clin. Immunol., Paris, May 10–15.

  61. Prevost, M., Turenne, Y., Moote, D. W., Mazza, J., Petitclerc, C., Clermont, A., and Danzig, M. (1992), Presented at the XVth Eur. Cong. of Allergol. and Clin. Immunol., Paris, May 10–15.

Download references

Author information

Authors and Affiliations

  1. Medical Marketing, Schering-Plough, 2000 Galloping Hill Road, 07033, Kenilworth, NJ

    Izabela J. Roman & Melvyn R. Danzig

  2. Schering-Plough Research Institute, Schering-Plough, 2015 Galloping Hill Road, 07033, Kenilworth, NJ

    Izabela J. Roman & Melvyn R. Danzig

Authors
  1. Izabela J. Roman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Melvyn R. Danzig
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Roman, I.J., Danzig, M.R. Loratadine. Clinical Reviews in Allergy 11, 89–110 (1993). https://doi.org/10.1007/BF02802295

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02802295

Keywords

Search

Navigation