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Fatal pancreatitis, a consequence of excessive leukocyte stimulation?

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References

  1. Berndt, W. and Muller-Wieland, K., The role of lysosomal proteases in the pathogenesis of pancreatitis. Pol. Arch. Med. Wewn., 1970; 44: 535–537.

    CAS  Google Scholar 

  2. Creutzfeldt, W. and Schmidt, J., Aetiology and pathogenesis of pancreatitis. Scand. J. Gastroenterol. 1970; 5; Suppl 6: 47–62.

    CAS  Google Scholar 

  3. Berndt, W., Occurrence of a trypsinogen-activating and trypsin inactivating enzyme in autolytic pancreatic tissue of man. Int. Res. Comm. Syst., 1973; (73–12) 3-8–3-18

    Google Scholar 

  4. Schmidt, H. and Lankisch, P. G., Fat necrosis—a cause of pancreatic parenchymal necrosis, Digestion, 1978; 17: 84–91.

    Article  PubMed  CAS  Google Scholar 

  5. Niederau, C., Van Dyke, R. W., Scharschmidt, B.F. and Grendell, J.H., Rat pancreatic zymogen granules. An actively acidified compartment, Gastroenterology, 1986; 91: 1433–1442.

    PubMed  CAS  Google Scholar 

  6. Rinderknecht, H., Activation of pancreatic zymogens. Normal activation, premature intrapancreatic activation, protective mechanisms against inappropriate activation, Dig. Dis. Sci., 1986; 31: 314–321.

    Article  PubMed  CAS  Google Scholar 

  7. Braganza, J.M., Panereatic disease: a casualty of hepatic detoxification? Lancet ii, 1983; 1000–1003.

    Article  Google Scholar 

  8. Dormandy, T.L., An approach to free radicals, Lancet ii, 1983, 1010–1014.

    Article  Google Scholar 

  9. Sanfey, H., Bulkley, G.B., and Cameron, J.L., The role of oxygen derived free radicals in the pathogenesis of acute pancreatitis, Am. Surg., 1984; 200: 405–413.

    CAS  Google Scholar 

  10. Sarr, M.G., Bulkley, G.B. and Cameron, J.L., The role of leukocytes in the production of oxygenderived free radicals in acute experimental pancreatitis, Surgery, 1987; 101: 292–296.

    PubMed  CAS  Google Scholar 

  11. Weissmann, G., Serhan, C., Korchak, H. and Smolen, J. E., Neutrophils; release of mediators of inflammation with special reference to rheumatoid arthritis. Ann. N.Y. Acad. Sci. 1982; 389: 11–24.

    Article  PubMed  CAS  Google Scholar 

  12. Rae, S.A., Davidson, E.M. and Smith, M.J.H., Leukotriene B4, an inflammatory mediator in gout, Lancet ii, 1982; 1122–1123.

    Article  Google Scholar 

  13. Fantone, III, J.C., Johnson, K.J., Kaplan, J. and Ward, P.A., In vivo damage of rat lungs by oxygen metabolites. J. Clin. Invest., 1981; 67: 983–993.

    Article  PubMed  Google Scholar 

  14. Hunninghake, G.W., Gadek, J.E., Kawanami, O., Ferrans, V.J. and Crystal, R.G., Inflammatory and immune processes in human lung in health and disease: evaluation by broncho-alveolar lavage. Am. J. Pathol., 1979; 97: 149–206.

    PubMed  CAS  Google Scholar 

  15. Barie, P.S., Tahamont, M.V. and Malik, A.B., Prevention of increased pulmonary vascular permeability after pancreatitis by granulocyte depletion in sheep, Amer. Rev. Respir. Dis., 1982; 126: 904–908.

    CAS  Google Scholar 

  16. Lasson, A and Ohlsson, K., Acute pancreatitis. The correlation between clinical course, protease inhibitors and complement and kinin activation, Scand. J. Gastroenterol., 1984; 19: 707–710.

    PubMed  CAS  Google Scholar 

  17. Aasen, A.O. and Ohlsson, K., Release of granulocyte elastase in lethal canine endotoxin shock, Hoppe-Seyler's Z. Physiol. Chem., 1978; 359: 683–690.

    PubMed  CAS  Google Scholar 

  18. Kwann, H.C., Anderson, M.C. and Gramatica, L.A., A study of pancreatic enzymes as a factor in the pathogenesis of disseminated intravascular coagulation during acute pancreatitis. Surgery, 1973; 69: 663–672.

    Google Scholar 

  19. Morgan, A.P., Jenny, M. and Haessler, H., Phospholipids, acute pancreatitis and the lungs: effect of lecithinase infusion on pulmonary surfactant activity, Ann. Surg., 1968; 157: 329–333.

    Article  Google Scholar 

  20. Bohn, E. and Muller-Berghaus, G., The effect of leukocyte and platelet transfusion on the activation of intravascular coagulation by endotoxin in granulocytopenic and thrombocytopenic rabbits, Am. J. Pathol. 1976; 84: 239–258.

    PubMed  CAS  Google Scholar 

  21. Geokas, M.C., Rinderknecht, H., Swanson, V. and Haverback, B.J., The role of elastase in acute hemorrhagic pancreatitis in man, Lab. Invest., 1968; 19: 235–239.

    Google Scholar 

  22. Rao, K.N., Tuma, J. and Lombardi, B., Acute hemorrhagic pancreatic necrosis in mice. Intraparenchymal activation of zymogens and other enzyme changes in pancreas and serum. Gastroenterology, 1976; 70: 720–726.

    PubMed  CAS  Google Scholar 

  23. Shasby, D.M., Shasby, S.S. and Peach, M.J., Granulocytes and phorbol myristate acetate increase permeability to albumin of cultured endothelial, monolayers and isolated perfused lungs. Am. Rev. Respir. Dis., 1983; 127: 72–76.

    PubMed  CAS  Google Scholar 

  24. Brodrick, J.W., Geokas, M.C., Largman, C., Fassett, M. and Johnson, J.H., Molecular forms of immunoreactive pancreatic cationic trypsin in pancreatitis sera, Physiol. 1979; 237: E474-E480.

    CAS  Google Scholar 

  25. Scheele, G., Adler, G. and Kern, H., Exocytosis occurs at the lateral plasma membrane, of pancreatic acinar cell during supramaximal secretagogue stimulation, Gastroenterology, 1987; 92: 345–353.

    PubMed  CAS  Google Scholar 

  26. Denzlinger, C., Rapp, S., Hagmann, W. and Keppler, D., Leukotrienes as mediators in trauma, Science, 1985; 230: 330–332.

    Article  PubMed  CAS  Google Scholar 

  27. Tracey, K.J., Beutler, B., Lowry, S.F., Merryweather, J., Wolpe, S., Milsark, I.W., et al., Shock and tissue injury induced by recombinant human cachectin. Science, 1986: 234: 470–474.

    Article  PubMed  CAS  Google Scholar 

  28. Hagmann, W., Denzlinger, C. and Keppler, D, Role of peptide leukotrienes and their hepatobiliary elimination in endotoxin action, Circ. Shock, 1984; 14: 223.

    PubMed  CAS  Google Scholar 

  29. Braganza, J.M., Holmes, A.M., Morton, A.R., Stalley, L., Ku, R. and Kishen, R., Acetylcysteine to treat complications of pancreatitis. Lancet i, 1986; 914–915.

    Article  Google Scholar 

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Rinderknecht, H. Fatal pancreatitis, a consequence of excessive leukocyte stimulation?. Int J Pancreatol 3, 105–112 (1988). https://doi.org/10.1007/BF02798921

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