Trace-element contents of human fetal liver of 12–22 weeks gestation

Abstract

There are some papers in the literature on the trace element contents of fetal livers of 20-wk gestation time and over. However, there is very little information on this subject for fetal livers of less than 20-wk gestation. We have initiated a program on the measurement of trace elements in fetal livers of 12–22-wk gestation, using thick-target X-ray fluorescence analysis.

The liver samples were obtained from freshly aborted fetuses. After removing blood from the samples, they were chopped into small pieces and freeze dried. The resulting material was ground into fine powder and compressed into 3-mm thick pellets, with boric acid backing. A similar pellet was also made of NBS—Bovine Liver—which was used as the standard for calculating the absolute concentrations of different trace elements.

The measurements were carried out using a commercial Wave-Length-Dispersive XRF-System. Different X-ray tubes were used for different sets of elements in order to maximize the detection sensitivity. The results are compared with those of fetal liver of longer gestation and adult livers.