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Some medical applications of the oxford scanning proton microprobe

  • Localization of Trace Elements
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Abstract

Results from several medical investigations carried out using the Oxford scanning proton microprobe are presented, including maps of the hepatic copper-distribution in primary biliary cirrhosis and maps of the iron distribution in primary hemochromatosis. Preliminary studies of human nervous tissue reveal that morphologically recognizable structures can be differentiated using precision elemental mapping, and this may lead to a powerful new way of distinguishing subtle perturbations of structure and function. In further prelimianry studies, localized aluminum structures have been observed in Alzheimer’s disease tissue at bulk levels of less than parts per million.

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Author notes

  1. D. J. T. Vaux

    Present address: Dept. of Cell Biology, Yale University School of Medicine, Sterling Hall of Medicine, P. O. Box 3333, 06510-8002, New Haven, Connecticut, USA

Authors and Affiliations

  1. John Radcliffe Hospital, Oxford, UK

    D. J. T. Vaux

  2. Nuclear Physics Laboratory, Keble Road, Oxford, UK

    G. W. Grime & F. Watt

Authors
  1. D. J. T. Vaux
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  2. G. W. Grime
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  3. F. Watt
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Vaux, D.J.T., Grime, G.W. & Watt, F. Some medical applications of the oxford scanning proton microprobe. Biol Trace Elem Res 13, 115–133 (1987). https://doi.org/10.1007/BF02796626

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