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Possible pathogenic mechanisms on trimethyltin-induced lesions in the hippocampus of adult and neonatal rats

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  • Applications of Trace Metal Analysis to Basic Problems in Neurobiology
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Abstract

The extent of trimethyltin (TMT) induced lesions in the rat hippocampal formation was reviewed. Adult rats were treated with a single dose of 6.0 mg TMT/kg body wt and were sacrificed between 3–60 d following exposure. In the hippocampal formation, the granule cells of fascia dentata showed early changes, which subsided considerably at a later time of the intoxication. On the other hand, destruction of the pyramidal neurons in the Ammon’s horn became more pronounced with time, resulting in an extensive destruction of this structure. It is interesting to note that the CA3 neurons in the septal portion of the Ammon’s horn were more vulnerable than those located more temporally, whereas the reverse pattern was observed for the dentate granule cells as well as for the CA1,2 neurons of the Ammon’s horn. Special stain for zinc (Timm’s method) also revealed a progressive depletion of zinc in the mossy fibers. When neonatal rats were treated at various times with a single injection of TMT, rapid and progressive destruction of the Ammon’s horn was observed in animals injected between postnatal day (PND) 5–15. The progression of neuronal involvement was CA3b →CA3a, b →CA3(a,b,c)→CA3+CA2→entire Ammon’s horn (CA1,2,3). This pattern of pathological lesion was in good concert with morphological development and functional maturity of the hippocampal formation. Destruction of the Ammon’s horn neurons was proposed to be the result of hyperexcitation of the dentate granule neurons under the influence of TMT. Other possible mechanisms are also discussed.

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References

  1. P. Smith and L. Smith,Chem. Br. 11, 208 (1975).

    CAS  Google Scholar 

  2. I. Watanabe,Effect of triethyltin on the developing brain of the mouse, inNeurotoxicology, L. Roizin, H. Shiraki, and N. Grcevic, eds., Raven, New York, NY, 1977, p. 317.

    Google Scholar 

  3. I. Watanabe, Organotins, inExperimental and Clinical Neurotoxicology. P. S. Spencer and H. H. Schaumburg, eds., Williams and Wilkins, Baltimore, MD, 1980 p. 545.

    Google Scholar 

  4. A. W. Brown, W. N. Aldridge, B. W. Street, and R. D. Verschoyle,Am. J. Pathol. 97, 59 (1979).

    PubMed  CAS  Google Scholar 

  5. T. W. Bouldin, N. D. Goines, C. R. Bagnell, and M. R. Krigman,Am. J. Pathol. 104, 237 (1981).

    PubMed  CAS  Google Scholar 

  6. L. W. Chang, T. M. Tiemeyer, G. R. Wenger, and D. E. McMillan,Neurobehav. Toxicol. Teratol. 4, 149 (1982).

    PubMed  CAS  Google Scholar 

  7. L. W. Chang, T. M. Tiemeyer, G. R. Wenger, D. E. McMillan, and K. R. Reuhl,Environ. Res. 29, 435 (1982).

    Article  PubMed  CAS  Google Scholar 

  8. L. W. Chang, T. M. Tiemeyer, G. R. Wenger, D. E. McMillan, and K. R. Reuhl,Environ. Res. 29, 435 (1982).

    Article  PubMed  CAS  Google Scholar 

  9. L. W. Chang, T. M. Tiemeyer, G. R. Wenger, and D. E. McMillan,Environ. Res. 30, 399 (1983).

    Article  PubMed  CAS  Google Scholar 

  10. L. W. Chang, G. R. Wenger, D. E. McMillan, and R. W. Dyer,Neurobehav. Toxicol. Teratol. 5, 337 (1983).

    PubMed  CAS  Google Scholar 

  11. L. W. Chang, G. R. Wenger, and D. E. McMillan,Environ. Res. 34, 123 (1984).

    Article  PubMed  CAS  Google Scholar 

  12. L. W. Chang and R. W. Dyer,Neurobehav. Toxicol. Teratol. 5, 443 (1983).

    PubMed  CAS  Google Scholar 

  13. R. S. Dyer, T. J. Walsh, H. S. Swartzwelder, and M. J. Wayner, (eds.)Neurobehav. Toxicol. Teratol. 4,(2), 1 (1982).

    Google Scholar 

  14. G. R. Wenger, D. E. McMillan, and L. W. Chang,Neurobehav. Toxicol. Teratol. 4, 157 (1982).

    PubMed  CAS  Google Scholar 

  15. G. R. Wenger, D. E. McMillan, and L. W. Chang,Toxicol. Appl. Pharmacol. 73, 78 (1984).

    Article  PubMed  CAS  Google Scholar 

  16. G. R. Wenger, D. E. McMillan, and L. W. Chang,Toxicol. Appl. Pharmacol. 73, 89 (1984).

    Article  PubMed  CAS  Google Scholar 

  17. R. S. Dyer, W. F. Wonderlin, and T. L. Deshields,Neurobehav. Toxicol. Teratol. 4, 141 (1982).

    PubMed  CAS  Google Scholar 

  18. L. W. Chang, D. E. McMillan, G. R. Wenger, and R. S. Dyer,Toxicologist 3(1), 76 (1983).

    Google Scholar 

  19. L. W. Chang and R. S. Dyer,Neurobehav. Toxicol. Teratol.,7, 43 (1985).

    PubMed  CAS  Google Scholar 

  20. L. W. Chang, G. R. Wenger, D. E. McMillan, and R. S. Dyer,Neurobehav. Toxicol. Teratol. 5, 337 (1983).

    PubMed  CAS  Google Scholar 

  21. L. W. Chang,Neurotoxicology 5(2), 205 (1984).

    PubMed  CAS  Google Scholar 

  22. L. W. Chang,Bull, Environ. Contam. Toxicol. 33, 295 (1984).

    Article  CAS  Google Scholar 

  23. J. J. Valdes, C. F. Mactutus, R. M. Santos-Anderson, R. Dawson, Jr., and Z. Annau,Neurobehav. Toxicol. Teratol. 5, 357 (1983).

    PubMed  CAS  Google Scholar 

  24. R. S. Dyer, T. J. Walsh, W. F. Wonderlin, and M. Bercegeay,Neurobehav. Toxicol. Teratol. 4, 127 (1982).

    PubMed  CAS  Google Scholar 

  25. K. R. Reuhl, E. A. Smallridge, L. W. Chang, and B. A. Mackenzie,Neurotoxicology 4,(1), 19 (1983).

    PubMed  CAS  Google Scholar 

  26. K. R. Reuhl and J. M. Cranmer,Neurotoxicology 5(2), 187 (1984).

    PubMed  CAS  Google Scholar 

  27. T. V. P. Bliss, S. H. Chung, and R. V. Stirling,J. Physiol. 239, 92 (1974).

    Google Scholar 

  28. R. V. Stirling and T. V. P. Bliss,Prog. Brain Res. 48, 191 (1978).

    Article  PubMed  CAS  Google Scholar 

  29. W. M. Cowan, B. B. Stanfield, and K. Sishi, The development of the dentate gyrus, inCurrent Topics in Developmental Biology, vol. 15. R. K. Hung, ed., Academic, New York, NY, 1980, p. 103.

    Google Scholar 

  30. R. B. Chronister and L. E. White, Fiberarchitecture of the hippocampal formation: Anatomy, projections, and structural significance inThe Hippocampus, vol. I. R. L. Isaacson and K. H. Primbram, eds., Plenum, New York, NY, 1975, p. 9.

    Google Scholar 

  31. F. B. Gaarskjaer,J. Comp. Neurol. 178, 49 (1978).

    Article  PubMed  CAS  Google Scholar 

  32. F. B. Gaarskjaer,J. Comp. Neurol. 178, 73 (1978).

    Article  PubMed  CAS  Google Scholar 

  33. F.-M. S. Haug,Z. Anat. Entwickl.-Gesch. 145, 1 (1974).

    Article  CAS  Google Scholar 

  34. R. S. Sloviter and B. P. Damiano,Neurosci. Lett. 24, 279 (1981).

    Article  PubMed  CAS  Google Scholar 

  35. R. S. Sloviter and B. P. Damiano,Neuropharmacol. 20, 1003 (1981).

    Article  CAS  Google Scholar 

  36. L. W. Chang,Toxicol. Appl. Pharmacol. 6, 217 (1986).

    CAS  Google Scholar 

  37. R. S. Dyer,Neurobehav. Toxicol. Teratol. 4, 659 (1982).

    PubMed  CAS  Google Scholar 

  38. J. V. Nadler and G. J. Cuthbertson,Brain Res. 195, 47 (1980).

    Article  PubMed  CAS  Google Scholar 

  39. J. V. Nadler,Life Sci. 29, 2031 (1981).

    Article  PubMed  CAS  Google Scholar 

  40. R. S. Dyer, W. F. Wonderlin, T. J. Walsh, and W. K. Boyes,Soc. for Neurosci. Abst. 8(No. 23.7), 82 (1982).

    Google Scholar 

  41. R. S. Sloviter, A selective loss of Timm staining in the hippocampal mossy fiber pathway accompanies electrically induced hippocampal granule cell seizure activity in rats, inNeurobiology of Zinc, C. J. Frederickson and G. A. Howell, eds., Alan R. Liss, New York, NY, 1984, p. 127.

    Google Scholar 

  42. L. W. Chang and R. S. Dyer, Trimethyltin induced zinc depletion in rat hippocampus, inNeurobiology of Zinc, C. Frederickson and G. Howell, eds., Alan R. Liss, New York, NY, 1984, p. 275.

    Google Scholar 

  43. L. Zimmer, Z. Hasan, D. Woolley, and L. W. Chang,Neurotoxicol. 3,(3), 135 (1982).

    Google Scholar 

  44. S. V. Doctor, L. G. Costa, and S. D. Murphy,Toxicol. Lett. 13, 217 (1982).

    Article  PubMed  CAS  Google Scholar 

  45. L. G. Costa, S. V. Doctor, and S. D. Murphy,Life Sci. 31, 1093 (1982).

    Article  PubMed  CAS  Google Scholar 

  46. S. V. Doctor, L. G. Costa, D. A. Kendall, S. J. Enna, and S. D. Murphy,Toxicologist 2, 86 (1982).

    Google Scholar 

  47. S. V. Doctor, L. G. Costa, D. A. Kendall, and S. D. Murphy,Toxicology 25, 213 (1982).

    Article  PubMed  CAS  Google Scholar 

  48. S. V. Doctor, L. G. Sultatos, and S. D. Murphy,Toxicol. Lett. 17, 43 (1983).

    Article  PubMed  CAS  Google Scholar 

  49. L. W. Chang, and R. S. Dyer, Effects of trimethyltin on sensory neurons, inDisease and Chemically Induced Neurological Dysfunction. Neurobehav. Toxicol. Teratol. 5, 673 (1983).

  50. M. R. Krigman, T. W. Bouldin, and Y. Theoret,Am. Assoc. Neuropathol. 62nd Annual Meeting (Minneapolis), Abst. #127 (1986).

  51. D. L. DeHaven, M. R. Krigman, and R. B. Mailman,Neurobehav. Toxicol. Teratol. 8, 475 (1986).

    PubMed  CAS  Google Scholar 

  52. C. M. Forchetter, and J. L. Meed,Brain Res. 206, 208 (1981).

    Article  Google Scholar 

  53. D. W. Gallager, and G. K. Aghajanian,Eur. J. Pharmacol. 39, 357 (1976).

    Article  PubMed  CAS  Google Scholar 

  54. T. J. Walsh, W. E. Wilson, P. M. Hudson, T. Kanamatsu, J. S. Hong, and H. A. Tilson,Toxicologist 4, 115 (1984).

    Google Scholar 

  55. S. V. Doctor, L. G. Sultatos, and S. D. Murphy,Toxicol Appl. Pharmacol. 70, 165 (1983).

    Article  PubMed  CAS  Google Scholar 

  56. K. R. Reuhl, and B. A. Mackenzi,Toxicologist 3, 28 (1983).

    Google Scholar 

  57. D. G. Robertson, R. H. Gray, S. M. Kim, and F. A. de la Iglesia,Toxicologist 4, 33 (1984).

    Google Scholar 

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  1. Department of Pathology, University of Arkansas for Medical Sciences, 72205-7199, Little Rock, AR

    Louis W. Chang

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Chang, L.W. Possible pathogenic mechanisms on trimethyltin-induced lesions in the hippocampus of adult and neonatal rats. Biol Trace Elem Res 13, 77–88 (1987). https://doi.org/10.1007/BF02796623

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