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Selenium modifies carcinogen metabolism by inhibiting enzyme induction

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Abstract

Since selenium has been found to exert a protective action against carcinogenesis in various systems, the mechanism where-by sodium selenite inhibits DNA binding of the carcinogen, 7,12-dimethylbenz[a]anthracene, was investigated. It was found that selenite preferentially reduced DNA binding occurring through ananti-dihydrodiol epoxide metabolite of this carcinogen by inhibiting the induction of an enzyme system that generates this specific reactive metabolite.

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Author notes

  1. John A. Milner

    Present address: Department of Food Science and, Division of Nutritional Sciences, University of Illinois, 455 Bevier Hall, 61801, Urbana, IL

Authors and Affiliations

  1. LBI-Basic Research Program, NCI-Frederick Cancer Research Facility, 21701, Frederick, MD

    Anthony Dipple, Margaret A. Pigott & John A. Milner

Authors
  1. Anthony Dipple
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  2. Margaret A. Pigott
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  3. John A. Milner
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Dipple, A., Pigott, M.A. & Milner, J.A. Selenium modifies carcinogen metabolism by inhibiting enzyme induction. Biol Trace Elem Res 10, 153–157 (1986). https://doi.org/10.1007/BF02795568

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  • DOI: https://doi.org/10.1007/BF02795568

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