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The effect of selenium on cell proliferation in liver and colon

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Abstract

Epidemiologic and experimental evidence support a chemoprotective role for selenium (Se) in malignancy. Many mechanisms have been proposed to explain this phenomenon. In this study, the effect of Se intake on proliferation of hepatocytes and normal colonic epithelial cells in rats was determined using autoradiographic analysis of thymidine incorporation into DNA. Hepatocyte proliferation was measured 24 h after partial hepatectomy. Selenium-dosed animals demonstrated a significant reduction in hepatocyte labeling compared to the control group (6.1±2.6 vs 29.2±15.6,p=0.003). However, Se dosing did not affect the thymidine-labeling indices or distribution of labeling in colonic epithelium. Selenium may inhibit cell proliferation when it is the result of an unusually intense stimulus. This finding could explain in part the inhibitory effect of Se in some experimental cancer models.

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Author information

Authors and Affiliations

  1. Department of Internal Medicine, University of Nebraska Medical Center, 42nd and Dewey Avenue, 68105, Omaha, Nebraska

    Margaret A. Tempero

  2. the Veterans Administration Medical Center, Omaha, Nebraska

    Margaret A. Tempero

  3. the Memorial Sloan Kettering Cancer Center, New York, New York

    Eleanor E. Deschner & Morris S. Zedeck

Authors
  1. Margaret A. Tempero
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  2. Eleanor E. Deschner
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  3. Morris S. Zedeck
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Additional information

Dr. Tempero is a recipient of a Junior Clinical Faculty Fellowship from the American Cancer Society.

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Tempero, M.A., Deschner, E.E. & Zedeck, M.S. The effect of selenium on cell proliferation in liver and colon. Biol Trace Elem Res 10, 145–152 (1986). https://doi.org/10.1007/BF02795567

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  • DOI: https://doi.org/10.1007/BF02795567

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