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The effects of dietary methionine and glycine on lead toxicity in choline-deficient chicks

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Abstract

A 2×2×2 factorial experiment was conducted to study the effects of dietary methionine, glycine, and lead (Pb) in cholinedeficient chicks. The variables were: adequate or deficient methionine; adequate or excess glycine; and 0 or 1000 ppm lead (as Pb acetate 3H2O). Methionine stimulated growth when added to the methionine-deficient diets, but the response was greater when supplemental glycine was present. Addition of glycine to the glycine-adequate diets stimulated growth in the presence of adequate but not deficient methionine. The patterns of response to methionine were the same at both 0 and 1000 ppm dietary Pb. Added Pb depressed growth with all diets, but the depression was greater in methionine-deficient than in methionine-adequate diets. Hepatic nonprotein sulfhydryl (NPSH) and glutathione (GSH) concentrations were increased by both supplemental methionine and lead, and the effects were additive. Glycine levels did not significantly alter NPSH and GSH concentrations. Both methionine and glycine lowered Pb concentrations in kidney, and the effects were additive. The results are consistent with previous observations that added methionine ameliorates Pb-induced growth depression with choline-adequate diets, however, this effect is not as pronounced with choline-deficient diets. The results suggest (1) that glycine is limiting for growth in choline-deficient, methionine-adequate diets, and (2) that methionine and glycine may enhance Pb detoxification by different mechanisms.

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References

  1. H. D. Baernstein and J. A. Grand, J. Pharm. Exp. Therap.74, 18 (1942).

    CAS  Google Scholar 

  2. A. A. Mylroie, L. Moore, and U. Erogbogbo,Toxicol. Appl. Pharmacol. 41, 361 (1977).

    Article  CAS  PubMed  Google Scholar 

  3. T. K. Leeming and W. E. Donaldson,J. Nutr. 114, 2155 (1984).

    CAS  PubMed  Google Scholar 

  4. M. L. Scott, M. C. Nesheim, and R. J. Young,Nutrition of the Chicken, W. F. Humphrey, Geneva, NY (1982).

    Google Scholar 

  5. N. Ruiz, R. D. Miles, and R. H. Harms,World's Poult. Sci. J. 39, 185 (1983).

    Article  Google Scholar 

  6. D. M. Latta and W. E. Donaldson,Toxicologist 4(1), 653 (abstract) (1984).

    Google Scholar 

  7. J. M. Hsu,J. Nutr. 111, 26 (1981).

    CAS  PubMed  Google Scholar 

  8. S. Seshadri and A. Khanna,Curr. Sci. 51, 510 (1982).

    CAS  Google Scholar 

  9. N. Kaplowitz,Yale J. Biol. Med. 54, 497 (1981).

    CAS  PubMed  PubMed Central  Google Scholar 

  10. N. Tateishi, T. Higashi, S. Shinya, A. Naruse, and Y. Sakomoto,J. Biol. Chem. 75, 93 (1974).

    CAS  Google Scholar 

  11. H. Thor, P. Moldeus, R. Hermanson, J. Hogberg, D. J. Reed, and S. Orrenius,Arch. Biochem. Biophys. 188, 122 (1978).

    Article  CAS  PubMed  Google Scholar 

  12. J. Vina, R. Hems, and H. A. Krebs,Biochem. J. 170, 627 (1978).

    Article  CAS  PubMed  Google Scholar 

  13. D. J. Reed and S. Orrenius,Biochem. Biophys. Res. Commun. 77, 1257 (1977).

    Article  CAS  PubMed  Google Scholar 

  14. D. H. Baker, M. Sugahaka, and H. M. Scott,Poult. Sci. 47, 1376 (1968).

    Article  CAS  PubMed  Google Scholar 

  15. D. E. Greene, H. M. Scott, and B. C. Johnson,Poult. Sci. 41, 116 (1962).

    Article  Google Scholar 

  16. D. H. Baker and M. Sugahara,Poult. Sci. 49, 756 (1970).

    Article  CAS  Google Scholar 

  17. National Research Council, Nutrient Requirements of Poultry. National Acad. Sci., Washington, DC (1977).

  18. B. H. Lauterburg, T. Vaishnar, W. G. Stillwell, and J. A. Mitchell,Biochim. Biophys. Acta 272, 623 (1980).

    Google Scholar 

  19. G. L. Ellman,Arch. Biochem. Biophys. 82, 70 (1959).

    Article  CAS  PubMed  Google Scholar 

  20. J. T. Helwig and K. A. Council.SAS User's Guide, 1979. Cary, NC 27511.

  21. F. Binkley and V. duVigneud,J. Biol. Chem. 191, 531 (1951).

    CAS  PubMed  Google Scholar 

  22. R. O. Nesheim and B. C. Johnson,J. Nutr. 41, 149, (1950).

    CAS  PubMed  Google Scholar 

  23. C. R. Treadwell,J. Biol. Chem. 176, 1141 (1948).

    CAS  PubMed  Google Scholar 

  24. M. J. Norvell and M. C. Nesheim,Proc. Cornell Nutr. Conf. p. 31 (1969).

  25. D. M. Latta and W. E. Donaldson,Toxicologist 5(1), 540 (1985).

    Google Scholar 

  26. A. Meister and S. S. Tate,Annu. Rev. Biochem. 45, 559 (1976).

    Article  CAS  PubMed  Google Scholar 

  27. B. J. Fuhr and D. L. Rabenstein,J. Am. Chem. Soc. 95, 6944 (1973).

    Article  CAS  PubMed  Google Scholar 

  28. N. T. Christie and M. Costa,Biol. Trace Element Res. 6, 139 (1984).

    Article  CAS  Google Scholar 

  29. N. Castellino, P. Lamanna, and B. Griaco,Br. J. Ind. Med. 23, 237 (1966).

    CAS  PubMed  PubMed Central  Google Scholar 

  30. M. Cikrt,Br. J. Ind. Med. 29, 74 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  31. C. D. Klaasen and D. W. Shoeman,Toxicol. Appl. Pharmacol. 29, 434 (1974).

    Article  Google Scholar 

  32. D. M. Latta and W. E. Donaldson,Fed. Proc. 43(3), 314 (1984).

    Google Scholar 

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Authors and Affiliations

  1. Department of Poultry Science, NC State University, Box 7608, 27695-7608, Raleigh, NC

    Dorothy M. Latta & W. E. Donaldson

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  1. Dorothy M. Latta
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  2. W. E. Donaldson
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Paper No. 10213 of the Journal Series of the NC Agricultural Research Service, Raleigh, NC 27695-7601. The use of trade names implies neither endorsement of the product named nor criticism of similar products not mentioned by the NCARS.

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Latta, D.M., Donaldson, W.E. The effects of dietary methionine and glycine on lead toxicity in choline-deficient chicks. Biol Trace Elem Res 10, 129–136 (1986). https://doi.org/10.1007/BF02795565

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  • DOI: https://doi.org/10.1007/BF02795565

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