Abstract
Enzyme activities and protein content were determined in the cytosolic and mitochondrial fractions of liver homogenates obtained from Rh(III) complex-, thioacetamide- and thioacetamide + Rh(III) complex-treated rats.
The Rh(III) complex administered to nonthioacetamide-treated rats produced no significant changes either in the enzymatic activities assayed or in the protein concentration.
The Rh(III) complex administered to thioacetamide-treated rats produced significant restoration of the following altered values: cytosolic and mitochondrial aspartate aminotransferase, glutamate dehydrogenase, NADP-isocitrate dehydrogenase, and protein concentration. However, a further increase was produced in the activities of glucose-6-phosphate dehydrogenase and malic enzyme. These increases can be interpreted in terms of an enhancement of the NADPH-dependent detoxifying processes and of nucleic acid synthesis and repair.
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Cascales, C., Craciunescu, D.G., Martín-Sanz, P. et al. Effect of rhodium (III) complex on experimental carcinogenesis in the livers of rats treated with thioacetamide. Biol Trace Elem Res 11, 65–73 (1986). https://doi.org/10.1007/BF02795525
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DOI: https://doi.org/10.1007/BF02795525