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Biological half-time in rats exposed to nickel monosulfide (amorphous) aerosol by inhalation

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Abstract

This study reports the biological half-time of amorphous nickel monosulfide(NiS(A)) aerosol retained in rat lungs. Wistar male rats were exposed to NiS(A) aerosols (mass median aerodynamic diameter: 4.0 μm) for a single 4 h exposure, or for 7 h/d, 5 d/wk for 1 mo. The average exposure concentrations were controlled at 107 mg/m3 for the single exposure and at 8.8 mg/m3 for the repeated exposures by a dust generator consisting of a continuous fluidized bed with an overflow pipe and a screw feeder. After the exposures, the nickel contents in the rat organs, blood, and urine were measured and histopathological examinations were performed. The biological half time of NiS(A) in rat lungs was 20 h, which was extremely shorter than 21 mo of green nickel oxide (NiO(G)). There were no malignant tumors in any of the exposure groups.

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References

  1. ACGIH,Threshold Limit Values and Biological Exposure Indices for 1986–1987, Publications Office ACGIH, Cincinnati, Ohio, 1986, p. 39.

    Google Scholar 

  2. R. Saracci,Quantification of Occupational Cancer (Banbury report 9), Cold Spring Harbor Lab., 1981, p. 165.

  3. I. Tanaka, S. Ishimatsu, K. Matsuno, Y. Kodama, and K. Tsuchiya,Bio. Trace Element Res. 8, 203 (1985).

    CAS  Google Scholar 

  4. I. Tanaka, S. Ishimatsu, K. Matsuno, Y. Kodama, and K. Tsuchiya,ibid 9, 187 (1986).

    Article  CAS  Google Scholar 

  5. I. Tanaka, A. Horie, J. Haratake, Y. Kodama, and K. Tsuchiyaibid. Bio. Trace Element Res., in submission.

  6. I. Tanaka and T. Akiyama,Ann. Occup. Hyg. 28, 157 (1984).

    Article  PubMed  CAS  Google Scholar 

  7. Y. Kodama, S. Ishimatsu, K. Matsuno, I. Tanaka and K. Tsuchiya,Bio. Trace Element Res. 7, 1 (1985).

    CAS  Google Scholar 

  8. I. Tanaka, H. Hayashi, A. Horie, Y. Kodama, and K. Tsuchiya,J. UOEH 4, 441 (1982).

    CAS  Google Scholar 

  9. A. Horie, J. Haratake, I. Tanaka, Y. Kodama, and K. Tsuchiya,Bio. Trace Element Res. 7, 223 (1985).

    CAS  Google Scholar 

  10. A. G. Guyton,Am. J. Physiol. 150, 70 (1947).

    Google Scholar 

  11. K. Matsuno, I. Tanaka, and Y. Kodama,Envirn. Res. 41, 195 (1986).

    Article  CAS  Google Scholar 

  12. M. Costa, J. D. Heck, and S. H. Robinson,Cancer Res. 42, 2757 (1982).

    PubMed  CAS  Google Scholar 

  13. F. W. Sunderman, Jr.,J. UOEH,9, Suppl. 84 (1987).

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Authors and Affiliations

  1. Department of Environmental Health Engineering, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan

    Isamu Tanaka

  2. Department of Environmental Health, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, 807, Yahatanishi, Kitakyushu, Japan

    Sigeko Ishimatsu & Yasushi Kodama

  3. Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, 807, Yahatanishi, Kitakyushu, Japan

    Joji Haratake & Akio Horie

Authors
  1. Isamu Tanaka
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  2. Sigeko Ishimatsu
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  3. Joji Haratake
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  4. Akio Horie
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  5. Yasushi Kodama
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Tanaka, I., Ishimatsu, S., Haratake, J. et al. Biological half-time in rats exposed to nickel monosulfide (amorphous) aerosol by inhalation. Biol Trace Elem Res 17, 237–246 (1988). https://doi.org/10.1007/BF02795460

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  • DOI: https://doi.org/10.1007/BF02795460

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