Abstract
In rats, Mg deficiency caused a moderate hearing loss, measured by means of evoked potentials at 10 and 20 kHz, which was repaired after refeeding a normal diet.
Application of 700 mg/kg salicylic acid or injection of 5×100 mg/kg gentamicin also caused a reversible hearing loss in normally fed rats.
Treatment of Zn-deficient rats with salicylic acid produced a stronger although reversible hearing loss than in normally fed salicylate-treated rats. Treatment of Mg-deficient rats with gentamicin induced a strong hearing loss that was nearly complete and irreversible in 9 of 25 rats.
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References
J.-M. Aran, J.-P. Erre, A. Guilhaume and C. Aurousseau,Acta Otolaryngol. Suppl. 390, 3 (1982).
E. N. Myers, J.-M. Bernstein and G. Fostiropolous,New Engl. J. Med. 273, 587 (1965).
M. E. Kyle and J. J. Kocsis,Toxicol. Appl. Pharmacol. 81, 337 (1985).
D. Kleinknecht, P. Landais and B. Goldfarb,Contr. Nephrol. 55, 145 (1987).
J. Vormann, V. Höllriegl, H. J. Merker and T. Günther,Biol. Trace Elem. Res. 9, 55 (1986).
L. I. Rankin, H. Krous, R. Whang and A. W. Fryer,Clinical Res. 29, 745A (1981).
T. Günther, J. Vormann, H. J. Merker, R. Averdunk, H. W. Peter and K. Wonigeit,Magnesium 3, 29 (1984).
J. Vormann and T. Günther,Biol. Trace Elem. Res. 9, 378 (1986).
Z. Joachims, W. Babisch, H. Ising, T. Günther and M. Handrock,J. Acoust. Soc. Am. 74, 104 (1983).
T. Günther, H. Ising and Z. Joachims,Am. J. Otol. (in press).
W. J. Bettger and B. L. O’Dell,Life Sci. 28, 1425 (1981).
J. P. Burke and M. R. Fenton,Proc. Soc. Exp. Biol. Med. 179, 187 (1985).
B. Halliwell,Proc. Nutrit. Soc. 46, 13 (1987).
T. F. Slater, K. H. Cheeseman, M. J. Davies, K. Proudfoot and W. Xin,Proc. Nutrit. Soc. 46, 1 (1987).
I. Fridovich,Advances Enzymol. 41, 35 (1974).
R. L. Willson,Proc. Nutr. Soc. 46, 27 (1987).
E. Graf, J. R. Mahoney, R. G. Bryant and J. W. Eaton,J. Biol. Chem. 259, 3620 (1984).
M. E. Kyle and J. J. Kocsis,Chem.-Biol. Interact. 59, 325 (1986).
P. J. Thornalley and M. Vasak,Biochim. Biophys. Acta 827, 36 (1985).
J. P. Thomas, G. J. Bachowski and A. W. Girotti,Biochim. Biophys. Acta 827, 36 (1986).
J. M. Rogers, K. L. Keen and L. S. Hurley,Teratology 31, 89 (1985).
J. D. Hammermueller, T. Bray and W. J. Bettger,J. Nutrit. 117, 894 (1987).
L. G. Sillén and A. E. Martell,Stability Constants Suppl. No. 1, The Chemical Society, Burlington House, London, 1971, p. 484.
L. Weinstein, inThe Biochemical Basis of Therapeutics, 5th ed., L. S. Goodman and A. Gilman, eds. Macmillan Publishing Co., New York, 1975, p. 1167.
R. Pujol,Acta Otolaryngol. Suppl. 429, 29 (1986).
S. Au, N. D. Weiner and J. Schacht,Biochim. Biophys. Acta 902, 80 (1987).
J. Schacht,Hearing Res. 22, 297 (1986).
L. S. Ramsammy, C. Josepovitz, K.-Y. Ling, B. P. Lane and G. J. Kaloyanides,Biochem. Pharmacol. 36, 2125 (1987).
H. Saito, K. Inui and R. Hori,J. Pharmacol. Exptl. Therapy. 238, 1071 (1986).
W. Chutkow and S. Myers,Neurology 18, 963 (1968).
T. Günther,Magn.-Bull. 3, 91 (1981).
S. Nigam, R. Averdunk and T. Günther,Leuk. Prostagland. Med. 23, 1, (1986).
A. J. Hudspeth,Science 230, 745 (1985).
T. Günther,Magn.-Bull.,9, 55 (1987).
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Günther, T., Rebentisch, E., Vormann, J. et al. Enhanced ototoxicity of gentamicin and salicylate caused by Mg deficiency and Zn deficiency. Biol Trace Elem Res 16, 43–50 (1988). https://doi.org/10.1007/BF02795332
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DOI: https://doi.org/10.1007/BF02795332