Abstract
Ricin A chain ITs directed against a variety of the common cell-surface antigens associated with SCLC exerted selective toxic effects on SCLC cell lines. The potency of the cytotoxic effects matched or exceeded that previously reported for ricin A chain ITs directed against identical or similar antigens on other types of carcinoma, suggesting that SCLC may be uniquely sensitive to this type of IT.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Wawrzynczak, E. J. (1991), Systemic imunotoxin therapy of cancer: advances and prospects.Br. J. Cancer 64, 624–630.
Souhami, R. L., Beverley, P. C. L., and Bobrow, L. (eds.) (1988) Proceedings of the first international workshop on small cell lung cancer antigens.Lung Cancer 4, 1–116.
Beverley, P. C. L., Bobrow, L. G., Gilks, W., and Souhami, R. L. (eds.) (1991) Second international workshop on small cell lung cancer antigens.Br. J. Cancer, Suppl. XIV, 1–88.
Derbyshire, E. J. (1992)Immunotoxins to Human Small Cell Lung Cancer. Ph. D. Thesis, University of London.
Derbyshire, E. J. and Wawrzynczak, E. J. (1991) Monoclonal antibodies recognising the cluster 2 antigen associated with human small cell lung cancer mediate the toxic effects of ricin A chain in an indirect assay of immunotoxin cytotoxicity.Br. J. Cancer 63, Suppl. XIV, 74–77.
Derbyshire, E. J., de Leij, L., and Wawrzynczak, E. J. (1993) Refinement of an indirect immunotoxin assay of monoclonal antibodies recognising the human small cell lung cancer cluster 2 antigen.Br. J. Cancer,67, 1242–1247.
Derbyshire, E. J. and Wawrzynczak, E. J. (1992) An anti-mucin immunotoxin BrE-3-ricin A chain is potently and selectively toxic to human small cell lung cancer.Int. J. Cancer 52, 624–630.
Derbyshire, E. J., Menard, S., and Wawrzynczak, E. J. (1992) Cytotoxic activity and MLuC1-ricin A chain recognising the Y hapen associated with human small cell lung carcinoma.Fund. Clin. Immunol., in press.
Derbyshire, E. J., Stahel, R. A., and Wawrzynczak, E. J. (1992) Cytotoxic properties of a ricin A chain immunotoxin recognising the cluster 5A antigen associated with human small cell lung cancer.Cancer Immunol. Immunother. 35, 417–420.
Derbyshire, E. J., Henry, R. V., Stahel, R. A., and Wawrzynczak, E. J. (1992) Potent cytotoxic action of the immunotoxin SWA11-ricin A chain against human small cell lung cancer cell lines.Br. J. Cancer 66, 444–451.
Derbyshire, E. J., Stahel, R. A., and Wawrzynczak, E. J. (1992) Potentiation of a weakly active ricin A chain immunotoxin recognising the neural cell adhesion molecule.Clin. Exp. Immunol. 89, 336–340.
Wawrzynczak, E. J., Zangemeister-Wittke, U., Waibel, R., and et al. (1992) Molecular and biological properties of an abrin A chain immunotoxin designed for therapy of human small cell lung cancer.Br. J. Cancer 66, 361–366.
Zangemeister-Wittke, U., Lehmann, H.-P., Waibel, R., and et al. (1992) Action of a CD24-specific deglycosylated ricin A chain immunotoxin in conventional and novel models of small cell lung cancer xenograft.Int. J. Cancer 53, 521–528.
Jackson, D., Waibel, R., and Weber, E., et al. (1992) CD24, a signal transducing molecule expressed on human B cells, is a major surface antigen on small-cell lung carcinomas.Cancer Res. 52, 1–7.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wawrzynczak, E.J., Derbyshire, E.J. Immunotoxins to human small-cell lung cancer. Cell Biophysics 21, 13–23 (1992). https://doi.org/10.1007/BF02789474
Issue Date:
DOI: https://doi.org/10.1007/BF02789474