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Selenium status is decreased in patients with intrinsic asthma

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Abstract

Lowered selenium (Se) status has been observed in asthma patients. An increased production of reactive oxygen species (ROS) owing to inflammatory condition has also been found in these patients and thus antioxidant properties of Se via glutathione peroxidase (GPx) activity are of great importance. Concentrations of Se in plasma and erythrocytes as well as eryth-rocyte GPx activity in 22 intrinsic asthma patients (five patients; all women were aspirin-sensitive) were compared with those of 33 control subjects. Se concentrations in both plasma and erythrocytes and GPx activity were decreased in intrinsic asthma patients. There were no significant differences in investigated parameters of Se status between aspirin-tolerant and aspirin-intolerant patients within intrinsic asthma group. Significantly high positive correlation between plasma and erythrocyte Se concentrations was found when regarding all subjects as a whole. Se supplementation might be beneficial to patients with intrinsic asthma, which may be at risk of Se deficiency.

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Authors and Affiliations

  1. Institute of Preventive and Clinical Medicine, Limbová 14, 833 01, Bratislava, Slovak Republic

    Jana Kadrabová, Alexander Mad'arič, Zuzana Kovačiková, František Podivínsky, Emil Ginter & František Gazdík

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  1. Jana Kadrabová
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  2. Alexander Mad'arič
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  3. Zuzana Kovačiková
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  4. František Podivínsky
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  5. Emil Ginter
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  6. František Gazdík
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Kadrabová, J., Mad'arič, A., Kovačiková, Z. et al. Selenium status is decreased in patients with intrinsic asthma. Biol Trace Elem Res 52, 241–248 (1996). https://doi.org/10.1007/BF02789165

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  • DOI: https://doi.org/10.1007/BF02789165

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