Abstract
Over the last two decades many strategies have been planned to design specific drugs for rare diseases to target their action at the DNA level. Advancements in our understanding of the interactions of small nonpeptide molecules with DNA have opened the doors for “rational” drug design. Special methods have now been developed to give accurate account of the precise location of ligand-DNA adducts on target DNA. We are now in a position to think of designing ligands that recognize particular sequences of base pairs. This work will allow us to enter into a new era of gene therapy for diseases like Cystic fibrosis, Alzheimer’s disease and many related disorders at genetic level. These ligands can also be employed in the treatment of various types of cancers. They may also be useful as highly specific probes to locate particular sequences in the genomic DNA.
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Thurston, D. E. and Thompson, A. S. (1990),Chem. Britain 8, 767.
Rawn, D. (1989),Text-Book of Biochemistry, Neil Patterson, Burlington, p. 829.
Zubay, G. (1989),Text-Book of Biochemistry, Macmillen, New York, pp. 792 and 924.
Fok, J. and Waring, M. J. (1972),Mol. Pharmacol. 8, 65.
Goldberg, I. H. and Friedman, P. A. (1971),Ann. Rev. Biochem. 40, 772.
Warpehoski, M. A. and Hurley, L. H. (1988),Chem. Res. Toxicol. 1, 315.
Barton, J. K. (1986),Science 233, 727.
van Dyke, M. M. and Dervan, P. B. (1984),Science 225, 1122.
Hurley, L. H. and Boyd, L. F. (1987),Ann. Rep. Med. Chem. 22, 259.
Taylor, J. S., Schultz, P. G., and Dervan, P. B. (1984),Tetrahedron 40, 457.
Patel, D. J. and Shapiro, L. (1987),Ann. Rev. Biophys. Chem. 16, 423.
Hopfinger, A. J. (1985),J. Med. Chem. 28, 1133.
Harris, T. M., Stones, M. P., and Harris, C. M. (1988),Chem. Res. Toxicol. 1,77.
Hurley, L. H. and Boyd, L. F. (1988),Trends Pharmacol. Sci. 9, 402.
Hamilton, L. D., Fuller, W., and Reich, E. (1963),Nature 198, 538.
Labouret, B. (1965),Bull. Soc. Chem. Biol. 47, 1579.
Pullman, B. (1989), inAdvances in Drug Research, vol. 18, Academic, New York, p. 1.
Gilbert, D. E. and Feigon, J. (1991),Biochemistry 30, 2483.
Quigley, G. J., Wang, A. H. J., Ughetto, G., vander Marel, G. A., van Boom, J. H., and Rich, A. (1980),Proc. Natl. Acad. Sci. USA 77, 7204.
Lee, S. J. and Waring, M. J. (1978),Biochemistry 73, 129.
Waring, M. J. and Wakelin, L. P. G. (1974),Nature 252, 653.
Low, C. M. L., Drew, H. R., and Waring, M. J. (1984),Nucleic Acid Res. 15, 5845.
Egli, M., Williams, L. D., Frederick, C. A., and Rich, A. (1991),Biochemistry 30, 1364.
Li, L. H., Kruntzel, S. L., Murch, L. L., Pschigoda, L. M., and Krueger, W. C. (1979),Cancer Res. 39, 4816.
Ennis, H. L. (1981),Antimicrob. Agents Chemother.19, 657.
Bhuyan, B. K. (1967), inAntibiotics, vol. 1, Gottlieb, D. and Shaw, P. D., eds., Springer, New York, p. 173.
Bhuyan, B. K. and Reusser, F. (1970),Cancer Res. 30, 984.
Kerster, W., Kerster, F., and Szybalski, W. (1966),Biochemistry 5, 236.
Waring, M. J. (1970),J. Mol. Biol. 54, 247.
Das, G. C., Dasgupta, S., and Dasgupta, N. N. (1974),Biochem. Biophys. Acta 353, 274.
Sinha, R. K., Talapatra, P., Mitra, A., and Mazumdar, S. (1977),Biochem. Biophsy. Acta 474, 199.
Gale, E. F., Cundliffe, E., Reynolds, P. E., Richmond, M. H., and Waring, M. J. (1981), inThe Molecular Basis of Antibiotic Action, Neidle, S. and Waring, M. J., eds., Wiley, London, p. 285.
Searle, M. S., Hall, J. G., Denny, W. A., and Wakelin, L. P. G. (1988),Biochemistry 27, 4340.
Williams, L. D., Egli, M., Gao, Q., Bash, P., van den Marel, G. A., van Boom, J-H., Rich, A., and Fredrick, C. A. (1990a),Proc. Natl. Acad. Sci. USA 87, 2225.
Zhang, X. and Patel, D. G. (1990),Biochemistry 29, 9457.
Fox, K. R., Brasset, C., and Waring, W. J. (1985),Biochem. Biophys. Acta 840, 383.
Collier, D. A., Neidle, S., and Brown, J. R. (1984),Biochem. Pharmacol. 33, 2877.
Liaw, Y. C., Gao, Y-G., Robinson, H., van der Marcel, G. A., van Boom, J. H., and Feigon, J. (1991),Biochemistry 28, 9913.
Neidle, S. and Abraham, Z. (1984),CRC, Crit. Rev. Biochem. 17, 73.
Tsai, C. C., Jain, S. C., and Sobell, H. M. (1977),J. Mol. Biol. 114, 301.
Jain, S. C., Tsai, C. C., and Sobell, H. M. (1977),J. Mol. Biol. 114, 317.
Sobell, H. M. and Jain, S. C. (1972),J. Mol. Biol. 68, 21.
Scott, E. V., Zon, G., Marzilli, L. G., and Wilson, W. D. (1988),Biochemistry 27, 7940.
Wang, A. H., Ughtto, G., Quigley, G. J., and Rich, A. (1987),Biochemistry 26, 1152.
Denny, W. A., Baguley, B. C., and Cain, B. F. (1983), inMolecular Aspects of Anticancer Drug Action, Neidle, S. and Waring, M. J., eds., Macmillian, London, p. 1.
Abraham, Z. H. L., Agbandje, M., Neidle, S., and Acheson, R. M. (1988),J. Biomol. Struct. Dyna. 6, 471.
Sherman, S. E., Gibson, D., Wang, A. H-J., and Lippard, S. J. (1985),Science 230, 412.
Ward, D. C., Reich, E., and Goldberg, I. G. (1965),Science 149, 1259.
Behr, W., Honikel, K., and Hertmann, G. (1969),Eur. J. Biochem. 9, 82.
Kamiyama, M. (1968),J. Biochem. 63, 563.
Tanious, F. A., Yen, S-F., and Wilson, W. D. (1991),Biochemistry 30, 1813.
Drew, H. and Travers, A. (1984),Cell 37, 491.
Kuwabara, M., Yoon, C., Goyne, T., Thederahu, T., and Sigman, D. (1986),Biochemistry 25, 7401.
Barton, J. K. (1986),Science 233, 727.
Sigman, D. S. (1986),Acc. Chem. Res. 19, 180.
Francois, J-C, Saison-Behmoaras, T., and Helene, C. (1988),Nucleic Acids Res. 16, 11431.
Francois, J-C, Saison-Behmoaras, T., Chassignol, M., Thecong, N. T., Sun, J-S., and Helene, C. (1988),Biochemistry 27, 2272.
Chan, C. H. and Sigman, D. S. (1986),Proc. Natl. Acad. Sci. USA 83, 7147.
Chan, C. H. and Sigman, D. S. (1987),Science 237, 1197.
Sun, J-S., Francois, J-C, Lavery, R., Saison-Behmoaras, T., Montenay-Garestier, T., Thuong, N. T., and Helene, C. (1988),Biochemistry 27, 6039.
Francois, J-C, Saison-Behmoaras, T., Chassignol, M., Thuong, N. T., and Helene, C. (1989),J. Biol. Chem. 264, 5891.
Veal, J. M. and Rill, R. L. (1991),Biochemistry 30, 1132.
Kohn, K. W., Hartley, J. A., and Mattes, W. B. (1987),Nucleic Acids Res. 15, 10531.
Umezawa, H. (1978), inBleomycin: Current Status and New Developments, Carter, S. K., Crooke, S. T., and Umezawa, H., eds., Academic Press, New York, p. 15.
Dabrowiak, J. C. (1980),J. Inorg. Biochem. 13, 317.
Berger, R. M., Peisach, J., and Horwitz, S. B. (1981),Life Sci. 28, 715.
Sausville, F. A., Pesiach, J., and Horwitz, S. B. (1976),Biochemistry 17, 2740.
Hecht, S. M. (1986),Fed. Proc. 45, 2784.
Cirriol, M. R., Pesiach, J., and Horwitz, S. B. (1982),J. Biol. Chem. 257, 8612.
Berger, R. M., Pesiach, J., and Horwitz, S. B. (1982),J. Biol. Chem. 257, 8612.
Gutterberidge, J. M. C., Beard, P. C., and Quinlan, J. (1985),Biochem. Int. 10, 441.
Sausville, F. A., Pesiach, J., and Horwitz, S. B. (1978),Biochemistry 17, 2740.
Gutterberidge, J. M. C. and Shute, D. J. (1981),J. Inorg. Biochem. 15, 349.
Rodriguez, L. O. and Hecht, S. M. (1982),Biochem. Biophys. Res. Commun. 104, 1470.
Gutterberidge, J. M. C. and Halliwell, B. (1987),Life Chem. Rep. 4, 113.
Petering, D. H., Byrnes, R. W., and Antholine, W. E. (1990),Chem. Biol. Interact. 73, 133.
Sugiura, Y., Suzuki, T., Kuwahara, J., and Tanaka, H. (1981),Biochem. Biophys. Res. Commun. 105, 1511.
Pratviel, G., Bernadom, J., and Mennier, B. (1989),Biochem. Pharmacol. 38, 133.
Gajewki, E., Okezie, I. A., Maral, D., and Berry, H. (1991),Biochemistry 30, 2444.
Kohda, K., Kasai, H., Ogawa, T., Suzuki, T., and Kawazoe, Y. (1989),Chem. Pharmacol. Bull. 37, 1028.
Gutterberidge, J. M. C., West, M., Eneff, K., and Floyd, R. A. (1990),Free Radical Res. Commun. 10, 158.
Benasutti, M. (1988),Biochemistry 27, 472.
Moffat, A. S. (1991),Science 252, 1374.
Hurley, L. H. (1989),J. Med. Chem. 32, 2027.
Dervan, P. B. (1986),Science 232, 464.
Tanzi, R. E., Hyslop, P. St. G., and Gusella, J. F. (1991),J. Biol. Chem. 266, 20579.
Marrow, J. and Isenberg, D. A. (1987), inAutoimmune Rheumatic Diseases, Blackwell Scientific, Oxford, p. 1.
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Prabhakar, P., Kayastha, A.M. Mechanism of DNA-drug interactions. Appl Biochem Biotechnol 47, 39–55 (1994). https://doi.org/10.1007/BF02788674
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DOI: https://doi.org/10.1007/BF02788674