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Intranuclear localization of histone acetylation inPhysarum polycephalum and the structure of functionally active chromatin

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Abstract

Based on studies of histone acetylation in vivo inPhysarum polycephalum, we present the following hypotheses: (1) Transcription-specific histone acetylation on histones H3 and H4 is a localized process at the nuclear matrix; (2) Histone acetylation in the S phase, which is specific for newly synthesized histones, occurs in an intranuclear nonlocalized process.

These hypotheses can explain: (1) the histone specificity of histone acetylation that is dependent on the functional state of the chromatin; (2) the apparent absence of turnover of histone acetylation in the bulk of the chromatin despite a definite low level of steady-state acetylation of all four core histones in bulk chromatin; (3) the pattern of butyrate-induced hyperacetylation observed for active and inactive chromatin.

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Authors and Affiliations

  1. Cell and Molecular Biology Laboratory, University of Sussex, BN1 9QG, Brighton, UK

    Jaap H. Waterborg & Harry R. Matthews

  2. Department of Biological Chemistry, Medical School, University of California at Davis, 95616, Davis, CA, USA

    Jaap H. Waterborg & Harry R. Matthews

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  1. Jaap H. Waterborg
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Waterborg, J.H., Matthews, H.R. Intranuclear localization of histone acetylation inPhysarum polycephalum and the structure of functionally active chromatin. Cell Biophysics 5, 265–279 (1983). https://doi.org/10.1007/BF02788625

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  • DOI: https://doi.org/10.1007/BF02788625

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