Summary
Arterial intimal thickening and thrombosis of the pancreatic artery has frequently been found in Watanabe heritable hyper-lipidemic (WHHL) rabbits. Three of the 20 rabbits used in this study showed histopathological findings such as intra- or interlobular fibrosis with lymphocytic infiltration, acinar degenerative changes, ductular proliferation and small ductal dilatations which were identical to those of human chronic pancreatitis. These findings were observed in discrete areas clearly demarcated from normal pancreatic parenchyma and adjacent to parenchymal necrosis. These discrete areas were developed just peripheral to regions of necrotic or inflammatory obstruction of the pancreatic duct, which might have been caused by parenchymal necrosis due to severe ischemia. The stasis of pancreatic juice in the ductal tree may result in such findings in the WHHL rabbit. Fat replacement of pancreatic parenchyma was observed in 17 of the 20 WHHL rabbits, and was classified into two types, diffuse and massive. Massive fat replacement may occur from fat necrosis and intra-lobular parenchymal necrosis.
Vascular alterations and secondary ischemia in the pancreas is one of the most important factors involved in the pancreatic lesions present in the WHHL rabbit.
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Watanabe Y. Serial inbreeding of rabbit with hereditary hyperlipidemia (WHHL) incidence and development of atherosclerosis and xanthomona. Atherosclerosis 1980;36:26.
Pfeffer R. Gradation of pancreatitis, edematous through haemorrhagic experimentally produced by controlled injection of microspheres into blood vessel in dogs. Surgery 1962;51:764.
McKay JW, Baggenstoss AH, Wollaeger EE. Infarct of the pancreas. Gastroenterology 1958;35: 256.
Uchida T. Pancreatic changes in the rabbit with experimental arterial stricture. J Jpn Pancreas Soc 1987;2:78.
Havel RJ. Pathogenesis, differentiation and management of hyperglyceridemia. Adv Int Med 1962;15:117.
Ditzel J, Thaysen HE. Increased hemoglobin-oxygen affinity in patients with pancreatitis associated with type I and V hyperlipoproteinemia. Adv Exp Med Biol 1977;94:423.
Hranilovich GT, Baggenstoss AM. Lesions of the pancreas in malignant hypertension. AMA Arch Pathol 1953;55:443.
Ammann R, Sulser H. Die senile chronische Pancreatitis—eine neue nosologische Einheit? Schweiz Med Wschr 1976;106:429.
Leger, L. Pancréatitis chroniques et arterites. Press Med 1963;71:1071.
Abe M, Hara Y et al. On the existence of ischemic chronic pancreatitis. Biliary Tract Pancreas 1982;3:1305.
Watson WC, Sakikali F. Celiac axis compression. Ann Int Med 1977;86:278.
Capt MS. Recurrent acute pancreatitis associated with systemic lupus erythematosus. Am J Digest Dis 1967;12:522.
Baron M, Brisson MW. Pancreatitis in systemic lupus erythematosus. Arthritis Rheum 1982;25:1006.
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Uchida, T., Tsuchiya, R., Harada, N. et al. Ischemic changes in the pancreas of Watanabe heritable hyper-lipidemic (WHHL) rabbits. Int J Pancreatol 3, 261–271 (1988). https://doi.org/10.1007/BF02788455
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DOI: https://doi.org/10.1007/BF02788455