Summary
A nonfunctioning islet cell tumor of the pancreas in a 68-yr-old female is reported. All of the laboratory data, including serum hormones, glucose, and tumor markers, were within normal limits A pancreatoduodenectomy was performed. Cut sections of the specimen revealed a cystic mass measuring 6.0×4.5×3.5 cm. Histologically, the tumor consisted of large acidophilic cells with bizarre giant nuclei. The tumor cells were positive for chromogranin-A, synaptophysin, neuron-specific enolase, and S-100 protein. Multifocal proliferation of endocrine cells, centroacinar cells and changes in acinar cells were found in the adjacent uninvolved pancreatic tissue. Ultrastructural studies of the tumor revealed clear nuclei with no zymogen, but immature neurosecretory granules in the cytoplasm of the tumor cells. These findings were consistent with those of nonfunctioning islet cell tumors, especially of the pleomorphic type. To the best of our knowledge, this is the first report on pleomorphic nonfunctioning pancreatic islet cell tumors.
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Abbreviations
- ABC:
-
avidin-biotin-peroxidase complex
- CEA:
-
carcino-embryonic antigen
- EMA:
-
epithelial membrane antigen
- HE:
-
hematoxylin and eosin
- NSE:
-
neuron-specific enolase
- PAS:
-
periodic acid-Schiff
- SCT:
-
solid and cystic tumor
References
Motojima K, Tomioka T, Tsunoda T, Kanematsu T. Immunohistochemical study of pancreatic cystadenocarcinoma.Am J Gastroenterol 1992; 87(1): 43–47.
Klöppel G, Morohoshi T, John HD, Oehmicken W, Opitz K, Angelkort A, Lietz H, Ruckert K. Solid and cystic acinar cell tumor of the pancreas.Virchows Arch [A] 1981; 392: 171–183.
Cubilla AL, Fitzgerald PJ. Tumors, of the exocrine pancreas, inAtlas of Tumor Pathology, 2nd ser., Fascicle 19, Armed Forces, Institute of Pathology Washington, DC, 1984, pp. 201–207.
Eckhauser F, Cheung P, Vinic A, Strodel WE, Lioyd RV, Thompson NW. Nonfunctioning malignant neuroendocrine tumors of the pancreas.Surgery 1986; 100: 978–988.
Kent R, van Heerden J. Nonfunctioning islet cell tumors.Ann Surg 1981; 193: 185–190.
Broder L, Carter S. Pancreatic islet cell carcinoma I. Clinical features of 52 patients.Ann Intern Med 1973; 79: 101–107.
Thompson G, ven Heerder J, Grant C, ILstrup DM. Islet cell carcinomas of the pancreas: a twenty-year experience.Surgery 1988; 104: 1011–1017.
Broughham T, Leslie J, Soto J, Hermann R. Pancreatic islet cell tumors.Surgery 1986; 99: 671–678.
Vencatesh S, Ordonetz N, Ajani J, Schultz PN, Hickey RC, Johnston DA, Samaan NA. Islet cell carcinoma of the pancreas: a study of the 98 patients.Cancer 1990; 65: 354–357.
Tsuchiya R Tomioka T, Izawa K, Noda T Tsunoda T. Collective review of small carcinomas of the pancreas.Ann Surg 1986; 203(1): 77–81.
Tomioka T, Inoue K, Yamamoto T, Motojima K, Tsunoda T, Kanematsu T. Solid and cystic tumor of the pancreas occurring without cyst formation in an adult male.Int J Pancreatol 1993; 14: 195–200.
Tomioka T, Miyagi N, Nakata T Miyata A, Amano M. A case report of nonfunctioning islet cell tumor—a review of Japanese literature.Jpn J Gastroenterol Surg 1983; 16: 1389–1394.
Kamisawa T, Fukayama M, Koike M, Tabata I, Okamoto A. So-called “Papillary and cystic neoplasm of the pancreas.” An immunohistochemical and ultrastructural study.Acta Pathol Jpn 1987; 37(5): 785–794.
Morohoshi T, Kanda M, Horie A, Chott A, Dreyer T, Klöppel G, Heitz PU. Immunocytochemical markers of uncommon pancreatic tumors: acinar cell carcinoma, pancreatoblastoma, and solid cystic (papillary-cystic) tumor.Cancer 1987; 59: 739–747.
Bani ST, Bani D, Biliotti G. The endocrine pancreas in patients with insulinomas. An immunocytochemical and ultrastructural study of the nontumoral tissue with morphometrical evaluations.Int J Pancreatol 1989; 5: 11–28.
Tomioka T, Fujii H, Hirota M, Ueno K, Pour PM. The patterns of β-cell regeneration in untreated diabetic and insulin-treated diabetic Syrian hamsters after streptozotocin treatment.Int J Pancreatol 1991; 8: 355–366.
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Taniguchi, K., Tomioka, T., Komuta, K. et al. Plaeomorphic nonfunctioning islet cell tumor of the pancreas. Int J Pancreatol 17, 83–89 (1995). https://doi.org/10.1007/BF02788362
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DOI: https://doi.org/10.1007/BF02788362