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Pancreas transplantation

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References

  1. Harris M, Hadden WC, Knowles WC, Bennett PH. Prevalence of diabetes and impaired glucose tolerance and plasma glucose levels in the U.S. population aged 20–74 years.Diabetes 1987; 36: 523–534.

    Article  PubMed  CAS  Google Scholar 

  2. Libman I, Songer T, Laporte R. How many people in the U.S. have IDDM?Diabetes Care 1993; 16: 841,842.

    PubMed  CAS  Google Scholar 

  3. Nathan DM. Long-term complications of diabetes mellitus.N Engl J Med 1993; 328: 1676–1684.

    Article  PubMed  CAS  Google Scholar 

  4. Selby JV, Fitzsimmons SC, Newman JM, Katz PT, Selpe S, Showstack J. The natural history and epidemiology of diabetic nephropathy: implications for prevention and control.JAMA 1990; 263: 1954–1960.

    Article  PubMed  CAS  Google Scholar 

  5. Chase HP, Jackson WE, Hoops SL, Cockerham RS, Archer PG, O'Brien D. Glucose control and the renal and retinal complications of insulin-dependent diabetes.JAMA 1989; 261: 1155–1160.

    Article  PubMed  CAS  Google Scholar 

  6. Brownlee M. Glycation and diabetic complications.Diabetes 1994; 43: 836–841.

    PubMed  CAS  Google Scholar 

  7. The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.N Engl J Med 1993; 29: 977–986.

    Article  Google Scholar 

  8. Robertson RP. Pancreatic and islet transplantation for diabetes: cures or curiosities?N Engl J Med 1992; 327: 861–868.

    Google Scholar 

  9. Sutherland DER. Pancreatic transplantation: an update.Diabetes Rev 1993; 1: 152–165.

    Google Scholar 

  10. Kelly WD, Lillehei RC, Merkel FK, Idezuki Y, Goetz FC. Allotransplantation of the pancreas and duodenum along with the kidney in diabetic nephropathy.Surgery 1967; 61: 827–837.

    PubMed  CAS  Google Scholar 

  11. Sutherland DER, Moudry-Munns K, Gruessner A. Pancreas transplant results in United Network for Organ Sharing (UNOS) United States of America (USA) Registry with a comparison to non-USA data in the international registry, inClinical Transplants 1993, Terasaki PI, Cecka JM, eds., UCLA Tissue Typing Laboratory, Los Angeles, 1994, pp. 47–69.

    Google Scholar 

  12. Moudry-Munns KC, Gruessner A, Sutherland DER. Analysis of United States pancreas transplant registry data.J Transplant Coordination 1994; 4: 18–22.

    Google Scholar 

  13. Sollinger HW, Ploeg RJ, Eckhoff DE, Stegall MD, Isaacs R, Pirsch JD, D'Alessandro AM, Knechtle SJ, Kalayoglu M, Belzer FO. Two hundred consecutive simultaneous pancreas-kidney transplants with bladder drainage.Surgery 1993; 114: 736–744.

    PubMed  CAS  Google Scholar 

  14. Stratta RJ, Taylor RJ, Zorn BH, Ozaki C, Larsen JL, Duckworth WC, Langnas AN, Wood RP, Wahl TO, Marujo WC, Li S, Shaw BW Jr. Combined pancreas-kidney transplantation: preliminary results and metabolic effects.Am J Gastroenterol 1991; 86: 697–703.

    PubMed  CAS  Google Scholar 

  15. Schulak JA, Mayes JT, Hricik DE. Combined kidney and pancreas transplantation: a safe and effective treatment for diabetic nephropathy.Arch Surg 1990; 125: 881–885.

    PubMed  CAS  Google Scholar 

  16. Sutherland DER, Gruessner R, Gillingham K, Moudry-Munns K, Dunn D, Brayman K, Morel P, Najarian JS. A single institution's experience with solitary pancreas transplantation: A multivariate analysis of factors leading to improved outcome, inClinical Transplants 1991, Terasaki PI, Cecka JM, eds., UCLA Tissue Typing Laboratory, Los Angeles, 1992, pp. 141–152.

    Google Scholar 

  17. Stratta RJ, Taylor RJ, Bynon JS, Lowell JA, Sindhi R, Wahl TO, Knight TF, Weide LG, Duckworth WC. Surgical treatment of diabetes mellitus with pancreas transplantation.Ann Surg 1994; 220: 809–817.

    Article  PubMed  CAS  Google Scholar 

  18. Stratta RJ, Sollinger HW, Perlman SV, D'Alessandro AM, Groshek M, Kalayoglu M, Pirsch JD, Belzer FO. Early diagnosis and treatment of pancreas allograft rejection.Transplant Int 1988; 1: 6–12.

    Article  CAS  Google Scholar 

  19. Gruessner RWG, Nakhleh R, Tzardis P, Schechner R, Platt JL, Gruessner A, Tomadze G, Najarian JS, Sutherland DER. Differences in rejection grading after simultaneous pancreas and kidney transplantation in pigs.Transplantation 1994; 57: 1021–1028.

    PubMed  CAS  Google Scholar 

  20. Stratta RJ, Taylor RJ, Wahl TO, Duckworth WC, Gallagher TF, Knight TF, Fischer JL, Neumann TV, Miller S, Langnas AN, Ozaki CF, Bynon JS, Larsen JL, Weide LG, Cassling RS, Talon AJ, Shaw BW Jr. Recipient selection and evaluation for vascularized pancreas transplantation.Transplantation 1993; 55: 1050–1096.

    Google Scholar 

  21. Brennan DC, Stratta RJ, Lowell JA, Miller SA, Taylor RJ. Cyclosporine challenge in the decision of combined kidney-pancreas versus solitary pancreas transplantation.Transplantation 1994; 57: 1606–1611.

    PubMed  CAS  Google Scholar 

  22. Manske CL, Thomas W, Wang Y, Wilson RF. Screening diabetic transplant candidates for coronary artery disease: identification of a low risk subgroup.Kidney Int 1993; 44: 617–621.

    Article  PubMed  CAS  Google Scholar 

  23. Cheung AHS, Sutherland DER, Gillingham KJ, McHugh LE, Moudry-Munns KC, Dunn DL, Najarian JS, Matas AJ. Simultaneous pancreas-kidney transplant versus kidney transplant alone in diabetic patients.Kidney Int 1992; 41: 924–929.

    Article  PubMed  CAS  Google Scholar 

  24. Stratta RJ, Taylor RJ, Ozaki CF, Bynon JS, Miller SA, Baker TL, Lykke C, Krobot ME, Langnas AN, Shaw BW Jr. The analysis of benefit and risk of combined pancreatic and renal transplantation versus renal transplantation alone.Surg Gynecol Obstet 1993; 177: 163–171.

    PubMed  CAS  Google Scholar 

  25. Schulak JA, Mayes JT, Hricik DE. Kidney transplantation in diabetic patients undergoing combined kidney-pancreas or kidney-only transplantation.Transplantation 1992; 53: 685–687.

    Article  PubMed  CAS  Google Scholar 

  26. Norden G, Nyberg G, Hedman L, Olausson M, Frisk B. Transplantation in patients with diabetic nephropathy: outcome of combined pancreas and kidney transplantation compared with kidney transplantation only.Transplant Int 1990; 3: 234–237.

    CAS  Google Scholar 

  27. Stratta RJ, Taylor RJ, Ozaki CF, Bynon JS, Miller SA, Knight TF, Fischer JL, Neumann TV, Wahl TO, Duckworth WC, Langnas AN, Shaw BW Jr. A comparative analysis of results and morbidity in Type I diabetics undergoing preemptive versus postdialysis combined pancreas-kidney transplantation.Transplantation 1993; 55: 1097–1103.

    PubMed  CAS  Google Scholar 

  28. Sutherland DER. Who should get a pancreas transplant?Diabetes Care 1988; 11: 681–685.

    PubMed  CAS  Google Scholar 

  29. Robertson RP. Pancreas transplantation in humans with diabetes mellitus.Diabetes 1991; 40: 1085–1089.

    Article  PubMed  CAS  Google Scholar 

  30. Sutherland DER, Dunn DL, Goetz FC, Kennedy WR, Ramsay RC, Steffes MW, Mauer SM, Gruessner RWG, Moudry-Munns KC, Morel P, Viste A, Robertson RP, Najarian JS. A 10-year experience with 290 pancreas transplants at a single institution.Ann Surg 1989; 210: 274–288.

    Article  PubMed  CAS  Google Scholar 

  31. Sollinger HW, Vernon WB, D'Alessandro AM, Kalayoglu M, Stratta RJ, Belzer FO. Combined liver and pancreas procurement with Belzer-UW solution.Surgery 1989; 106: 685–691.

    PubMed  CAS  Google Scholar 

  32. Stratta RJ, Taylor RJ, Spees EC, Langnas AN, Marujo WC, Li S, Ozaki C, Ranjan D, Duckworth RM, Shaw BW Jr. Refinements in cadaveric pancreas-kidney procurement and preservation.Transplant Proc 1991; 23: 2320–2322.

    PubMed  CAS  Google Scholar 

  33. Gores PF, Gillingham KJ, Dunn DL, Moudry-Munns KC, Najarian JS, Sutherland DER. Donor hyperglycemia as a minor risk factor and immunologic variables as major risk factors for pancreas allograft loss in multivariate analysis of a single institution's experience.Ann Surg 1992; 215: 217–230.

    Article  PubMed  CAS  Google Scholar 

  34. Hesse UJ, Sutherland DER. Influence of serum amylase and plasma glucose levels in pancreas cadaver donors on graft function in recipients.Diabetes 1989; 38(Suppl. 1): 1–3.

    PubMed  Google Scholar 

  35. Stratta RJ, Taylor RJ, Lowell JA, Bynon JS, Cattral MS, Frisbie K, Miller S, Brennan DC. OKT3 induction in 100 consecutive pancreas transplants.Transplant Proc 1994; 26: 546,547.

    PubMed  CAS  Google Scholar 

  36. Radio SJ, Stratta RJ, Taylor RJ, Linder J. The utility of urine cytology in the diagnosis of allograft rejection after combined pancreas-kidney transplantation.Transplantation 1993; 55: 509–516.

    Article  PubMed  CAS  Google Scholar 

  37. Perkins JD, Munn SR, Marsh CL, Barr D, Engen DE, Carpenter HA. Safety and efficacy of cystoscopically directed biopsy in pancreas transplantation.Transplant Proc 1990; 22: 665,666.

    PubMed  CAS  Google Scholar 

  38. Gaber AO, Gaber LW, Shokouh-Amiri MH, Hathaway D. Percutaneous biopsy of pancreas transplants.Transplantation 1992; 54: 548–550.

    Article  PubMed  CAS  Google Scholar 

  39. Bynon JS, Stratta RJ, Taylor RJ, Lowell JA, Cattral MS. Vascular reconstruction in 105 consecutive pancreas transplants.Transplant Proc 1993; 25: 3288,3289.

    PubMed  CAS  Google Scholar 

  40. Stratta RJ, Sollinger HW, Groshek M, D'Alessandro AM, Kalayoglu M, Pirsch JD, Belzer FO. Differential diagnosis of hyperamylasemia in pancreas allograft recipients.Transplant Proc 1990; 22: 675–677.

    PubMed  CAS  Google Scholar 

  41. Ozaki CF, Stratta RJ, Taylor RJ, Langnas AN, Bynon JS, Shaw BW Jr. Surgical complications in solitary pancreas and combined pancreas-kidney transplantation.Am J Surg 1992; 14: 546–551.

    Article  Google Scholar 

  42. Taylor RJ, Bynon JS, Stratta RJ. Kidney/pancreas transplantation: a review of the current status.Urol Clin North Am 1994; 21: 343–354.

    PubMed  CAS  Google Scholar 

  43. Kasiske BL. Risk factors for cardiovascular disease after renal transplantation.Mineral Electrolyte Metab 1993; 19: 186–195.

    CAS  Google Scholar 

  44. Gonyea J, Anderson C. Weight change and serum lipoproteins in recipients of renal allografts.Mayo Clin Proc 1992; 67: 653–657.

    PubMed  CAS  Google Scholar 

  45. Castelao AM, Barbera MJ, Blanco A, Fiol C, Grino JM, Bover J, Gilvernet S, Andres E, Serron D, Castineiras MJ, Alsina J. Lipid metabolic abnormalities after renal transplantation under cyclosporine and prednisone immunosuppression.Transplant Proc 1992; 24: 96–98.

    PubMed  CAS  Google Scholar 

  46. Julian BA, Laskow DA, Dubovski J, Dubovski EV, Curtis JJ, Quarles LD. Rapid loss of vertebral mineral density after renal transplantation.N Engl J Med 1991; 325: 544–550.

    Article  PubMed  CAS  Google Scholar 

  47. Diem P, Abid M, Redmon JB, Sutherland DER, Robertson RP. Systemic venous drainage of pancreas allografts as independent cause of hyperinsulinemia in Type I diabetic recipients.Diabetes 1990; 39: 534–540.

    Article  PubMed  CAS  Google Scholar 

  48. Larsen JL, Stratta RJ, Miller S, Taylor RJ. Hypoglycemic symptoms following pancreas transplantation.Clin Transplantation 1993; 7: 520–524.

    Google Scholar 

  49. Katz H, Homar M, Velosa J, Robertson P, Rizza R. Effects of pancreas transplantation on postprandial glucose metabolism.N Engl J Med 1991; 325: 1278–1283.

    Article  PubMed  CAS  Google Scholar 

  50. Morel P, Goetz FC, Moudry-Munns K, Freier E, Sutherland D. Long-term glucose control in patients with pancreatic transplants.Ann Int Med 1991; 115: 694–699.

    PubMed  CAS  Google Scholar 

  51. Osei K, Henry ML, O'Dorisio TM, Tesi RJ, Sommer BG, Ferguson RM. Physiological and pharmacological stimulation of pancreatic islet hormone secretion in Type I diabetic pancreas allograft recipients.Diabetes 1990; 39: 1235–1242.

    Article  PubMed  CAS  Google Scholar 

  52. Larsen JL, Stratta RJ, Miller SA, Ozaki CF, Taylor RJ, Duckworth WC. Evidence that fasting hyperproinsulinemia following combined pancreas-kidney transplantation diminishes over time.Transplantation 1993; 56: 1533–1537.

    PubMed  CAS  Google Scholar 

  53. Wang Q, Klein R, Moss SE, Klein BEK, Hoyer C, Burke K, Sollinger HW. The influence of combined kidney-pancreas transplantation on the progression of diabetic retinopathy: a case series.Ophthalmology 1994; 101: 1771–1776.

    Google Scholar 

  54. Peterson M, Vine A, University of Michigan Pancreas Transplantation Evaluation Committee. Progression of diabetic retinopathy after pancreas transplantation.Ophthalmology 1990; 97: 496–502.

    Google Scholar 

  55. Zech JC, Trepsat D, Gain-Gueugnon M, Lefronzois N, Martin X, Dubernard JM. Ophthalmological follow-up of Type I (insulin-dependent) diabetic patients after kidney and pancreas transplantation.Diabetologia 1991; 34(Suppl. 1): S89-S91.

    Article  PubMed  Google Scholar 

  56. Konigsrainer A, Miller K, Steurer W, et al Does pancreas transplantation influence the course of diabetic retinopathy?Diabetologia 1991; 34(Suppl. 1): S86-S88.

    Article  PubMed  Google Scholar 

  57. Ramsey R, Goetz F, Sutherland DER, Mauer SM, Robison LL, Cantrill H, Knobloch WH, Najarian JS. Progression of diabetic retinopathy after pancreas transplantation for insulin-dependent diabetes mellitus.N Engl J Med 1988; 318: 208–214.

    Article  Google Scholar 

  58. Scheider A, Meyer-Schwickerath E, Nusser J, Land W, Landgraf R. Diabetic retinopathy and pancreas transplantation: a three year followup.Diabetologia 1991; 34(Suppl. 1): S95-S99.

    Article  PubMed  Google Scholar 

  59. Bandello F, Vigano C, Secchi A, Martinengi S, Di Carlo V, Pozza G, Brancato R. Effect of pancreas transplantation on diabetic retinopathy: a 20-case report.Diabetologia 1991; 34(Suppl. 1): S92-S94.

    Article  PubMed  Google Scholar 

  60. Bohman SO, Tyden G, Wilczek H, Lundgren G, Jaremko G, Gunnarsson R, Ostman J, Groth CG. Prevention of kidney graft diabetic nephropathy by pancreas transplantation in man.Diabetes 1985; 34: 306–308.

    Article  PubMed  CAS  Google Scholar 

  61. Bilous R, Mauer S, Sutherland DER, Najarian JS, Goetz F, Steffes M. The effects of pancreas transplantation on the glomerular structure of renal allografts in patients with insulin-dependent diabetes mellitus.N Engl J Med 1989; 321: 80–85.

    Article  PubMed  CAS  Google Scholar 

  62. Fioretto P, Mauer SM, Bilous R, Goetz F, Sutherland D, Steffes M. Effects of pancreas transplantation on glomerular structure in insulin-dependent diabetic patients with their own kidneys.Lancet 1993; 342: 1193–1196.

    Article  PubMed  CAS  Google Scholar 

  63. Solders G, Gunnarsson R, Persson A, Wilczek H, Tyden G, Groth CG. Effects of combined pancreatic and renal transplantation on diabetic neuropathy: a two-year follow-up study.Lancet 1987; 2: 1232–1235.

    Article  PubMed  CAS  Google Scholar 

  64. Kennedy W, Navarro X, Goetz F, Sutherland D, Najarian J. Effects of pancreatic transplantation on diabetic neuropathy.N Engl J Med 1990; 322: 1031–1037.

    Article  PubMed  CAS  Google Scholar 

  65. Muller-Felber W, Landgraf R, Scheuer R, Wagner S, Reimers CD, Nusser J, Abendroth D, Illner WD, Land W. Diabetic neuropathy three years after successful pancreas and kidney transplantation.Diabetes 1993; 42: 1482–1485.

    Article  PubMed  CAS  Google Scholar 

  66. Navarro X, Kennedy WR, Loewenson RB, Sutherland DER. Influence of pancreas transplantation on cardiorespiratory reflexes, nerve conduction and mortality in diabetes mellitus.Diabetes 1990; 39: 802–806.

    Article  PubMed  CAS  Google Scholar 

  67. Secchi A, Martinenghi S, Galardi G, Comi G, Cannal N, Pozza G. Effects of pancreatic transplantation on peripheral and autonomic neuropathy.Transplant Proc 1991; 23: 1670,1671.

    Google Scholar 

  68. Aridge D, Reese J, Niehoff M, Karney K, Landsey L, Chun HS, George E, Garvin P. Effect of successful renal and segmental pancreatic transplantation on peripheral and autonomic neuropathy.Transplant Proc 1991; 23: 1670,1671.

    PubMed  CAS  Google Scholar 

  69. Nusser J, Scheuer R, Abendroth D, Illner WD, Land W, Landgraft R. Effect of pancreatic and/or renal transplantation on diabetic autonomic neuropathy.Diabetologia 1991; 34(Suppl. 1): S118-S120.

    Article  PubMed  Google Scholar 

  70. Hathaway DK, Abell T, Cardoso S, Hartwig MS, Gebely SE, Gaber AO. Improvement in autonomic and gastric function following pancreas-kidney versus kidney-alone transplantation and the correlation with quality of life.Transplantation 1994; 57: 816–822.

    Article  PubMed  CAS  Google Scholar 

  71. Kasiske BL. Risk factors for accelerated atherosclerosis in renal transplant recipients.Am J Med 1988; 84: 985–991.

    Article  PubMed  CAS  Google Scholar 

  72. Mahoney JF, Caterson RJ, Pollock CA, Jones M, Waugh DA, Sheil AGR. Coronary artery disease is the major late complication of successful cadaveric renal transplantation.Clin Transplantation 1990; 4: 129–132.

    Google Scholar 

  73. Van Oosterhout ECA, Reiber JHC, Begeman CJ, Van Baronswijk H, Gosszen HG, Lemkes HPJ. Coronary arteriosclerotic lesions in Type I diabetic patients eligible for combined renal-pancreatic transplantation.Transplant Proc 1994; 26: 497.

    PubMed  Google Scholar 

  74. Dafoe DC, Campbell DA, Merion RM, Rosenberg L, Rocher LL, Vinik AL, Vine AK, Turcotte JG. Pancreatic transplantation: University of Michigan.Transplant Proc 1987; 19(Suppl. 4): 55–62.

    PubMed  CAS  Google Scholar 

  75. Georgi FD, Bowers BL, Wright FH, Corry RJ. Comparison of fasting serum cholesterol levels between diabetic recipients who undergo renal-pancreas transplants and renal transplantation only.Transplant Proc 1989; 21: 2839,2840.

    PubMed  CAS  Google Scholar 

  76. Larsen JL, Stratta RJ, Miller S, Ozaki C, Taylor RJ, Duckworth WC. Lipid status improves following combined pancreas-kidney transplantation.Diabetes Care 1992; 15: 35–42.

    Article  PubMed  CAS  Google Scholar 

  77. Larsen J, Larson C, Hirst K, Miller SA, Ozaki CF, Taylor RJ, Tratta RJ. Lipid status after combined pancreas-kidney transplantation and kidney transplantation alone in Type I diabetes mellitus.Transplantation 1992; 54: 992–996.

    Article  PubMed  CAS  Google Scholar 

  78. Larsen J, Forsman J, Hirst K, Miller S, Taylor R, Stratta R. Gender differences in lipid alterations pre and post combined pancreas-kidney transplantation for insulin dependent diabetes mellitus.Metabolism 1994; 43: 1241–1247.

    Article  PubMed  CAS  Google Scholar 

  79. Larsen J, Forsman J, Miller S, Taylor R, Stratta R. APOA1, APOB, and APOA1/APOB before and after combined pancras-kidney transplantation.Transplant Proc 1994; 26: 503,504.

    PubMed  CAS  Google Scholar 

  80. Abendroth D, Landgraf R, Pfeiffer M, Reininger J, Seidel D, Land W. Diabetic microangiopathy and blood viscosity changes after pancreas and kidney transplantation.Transplant Proc 1994; 26: 491,492.

    PubMed  CAS  Google Scholar 

  81. Cheung ATW, Perez RV, Basadonna GP, Cox KL, Bry WI. Microangiopathy reversal and successful simultaneous pancreas-kidney transplantation.Transplant Proc 1994; 26: 493–495.

    PubMed  CAS  Google Scholar 

  82. Gross C, Zehrer C. Health-related quality of life outcomes of pancreas transplant recipients.Clin Transplantation 1992; 6: 165–171.

    CAS  Google Scholar 

  83. Hathaway DK, Hartwig MS, Milstead J, Elmer D, Evans S, Gaber AO. A prospectivestudy of changes in quality of life reported by diabetic recipients of kidney-only and pancreas-kidney allografts.J Transplant Coordination 1994; 4: 12–17.

    Google Scholar 

  84. Esmatje SE, Ricart MJ, Fernandez-Cruz L, Gonzalez-Clemente JM, Saenz A, Astudillo E. Quality of life after successful pancreas-kidney trnasplantation.Clin Trans plantation 1994; 8: 75–78.

    Google Scholar 

  85. Hering BJ, Geier C, Schultz AO, Bretzel RG, Federlin K, eds International Islet Transplant Registry, inIslet Transplant Registry, Islet Transplant Registry Newsletter. Justus-Liebig-University of Giessen, Giessen, 1994, pp. 4–7.

    Google Scholar 

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Stratta, R.J., Taylor, R.J., Larsen, J.L. et al. Pancreas transplantation. Int J Pancreatol 17, 1–13 (1995). https://doi.org/10.1007/BF02788353

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