Medical Oncology

, Volume 15, Issue 4, pp 279–281 | Cite as

Combined radiation and chemotherapy in posttransplant lymphoproliferative disorder

  • Donald E Tsai
  • Edward A Stadtmauer
  • Daniel J Canaday
  • David J Vaughn
Case Report


The optimal treatment for posttransplant lymphoproliferative disorder which has progressed despite a reduction in immunosuppression has not been defined. We report on two patients with stage I posttransplant lymphoproliferative disorder who developed progressive disease despite a reduction in the level of immunosuppression. Both patients were treated with combined short course CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy followed by involved-field radiation therapy. In both patients, a rapid response was obtained followed by complete remission. Combined modality therapy can be utilized successfully in progressive limited stage posttransplant lymphoproliferative disorder.


posttransplant lymphoproliferative disorder chemotherapy radiation therapy 


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Copyright information

© Stockton Press 1998

Authors and Affiliations

  • Donald E Tsai
    • 1
  • Edward A Stadtmauer
    • 1
  • Daniel J Canaday
    • 2
  • David J Vaughn
    • 1
  1. 1.Hematology-Oncology DivisionUniversity of Pennsylvania Medical CenterPhiladelphiaUSA
  2. 2.Department of Radiation OncologyUniversity of Pennsylvania Medical CenterPhiladelphiaUSA

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