Skip to main content
SpringerLink
Log in

Penicillin hypersensitivity: mechanism, diagnosis and management

  • Symposium: Pediatric Pharmacology
  • Published:
The Indian Journal of Pediatrics Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Sloane MB: Recapitulation of local antibiotic therapy.J Med Soc N J 53 (1956) 450.

    PubMed  CAS  Google Scholar 

  2. Idsoe O, Guthe T, Willcox RR, de Weck AL: Nature and extent of penicillin side-reactions, with particular refarence to fatalities from anaphylactic shock.Bull Wld Hlth Org 38 (1968) 159.

    CAS  Google Scholar 

  3. Landsteiner K, Jacobs J: Sensitisation of animals with simple chemical compounds. II.J Exp Med 64 (1936) 625

    Article  CAS  PubMed  Google Scholar 

  4. Eisen HN, Orris L, Belman S: Elicitation of delayed allergic skin reactions with haptens: the dependance of elicitation on hapten combination with protein.J Exp Med 95 (1952) 473.

    Article  PubMed  CAS  Google Scholar 

  5. Dewdney JM: Immunology of the antibiotics.In The antigens. Sela M (Ed): Vol IV, Academic Press, New York, (1977) p 73.

    Google Scholar 

  6. de Weck AL: Penicillins and cephalosporins.In Allergic reactions to drugs. de Weck AL, Bundgaard H (Eds); Springer-Verlag, Berlin, (1983) p 423.

    Google Scholar 

  7. Ahlstedt S, Ekstrom B, Svard PO, Sjoberg B, Kristofferson A, Ortengnen B: New aspects on antigens in penicillin allargy.CRC Crit Rev Toxicol 7 (1980) 219.

    Article  CAS  Google Scholar 

  8. Schulz KH, Schopf E, Wex O: Allergic occupational eczema die to ampicillin (In-German).Berufsdermatosen 18 (1970) 132.

    PubMed  CAS  Google Scholar 

  9. Dewdney JM: Pseudo-allergic reactions to antibiotics.In, PAR. Pseudo-allergic reactions, Dukor P, Kallos P, Schlumberger HD, West GB (Eds); Vol 1, Karger, Basal, (1980) p 273.

    Google Scholar 

  10. Butterly JM, Fishman L: Jarisch-Herxheimer reaction following panicillin therapy in case of syphilitic aortitis.J Am Med Ass 148 (1952) 370.

    CAS  Google Scholar 

  11. Hoigne R: Penicillins, cephalosporins and tetracyclines.In, Side effects of drugs, Dukes MNG, Meyler L (Eds); Vol VIII. Excerpta Medica, Amsterdam (1975) p 551.

    Google Scholar 

  12. Parker CW, Thiel JA: Studias in human allergy. A comparison of various penicilloyl polylysines.J Lab Clin Med 62 (1963) 482.

    PubMed  CAS  Google Scholar 

  13. Levine BB, Zolov BM: Prediction of penicillin allergy by immunological tests.J Allergy 43 (1969) 231.

    Article  PubMed  CAS  Google Scholar 

  14. Green GR, Rosenblum A: Report of the penicillin study group—American Academy of Allergy.J Allergy Clin Immunol 48 (1971) 331.

    Article  PubMed  CAS  Google Scholar 

  15. Solley GO, Gleich GJ, VanDellen RG: Penicillin allergy; clinical experience with a battery of skin test reagents.J Allergy Clin Immunol 69 (1982) 238.

    Article  PubMed  CAS  Google Scholar 

  16. Juhlin L, Ahlstedt S, Andal L, Ekstrom B, Svard PO, Wide L: Antibody reactivity in penicillin-sensitive patients determined with different penicillin derivatives.Int Arch Allergy Appl Immunol 54 (1977) 19.

    PubMed  CAS  Google Scholar 

  17. Sullivan TJ, Wedner HJ, Shatz GS, Yecies LD, Parker CW: Skin testing to detect penicillin allergy.J Allergy Clin Immunol 68 (1981) 171.

    Article  PubMed  CAS  Google Scholar 

  18. Brown BC, Price EV, Moore MB: Penicilloyl-polylysine as an intradermal test of penicillin sensitivity.JAMA 189 (1964) 87.

    Google Scholar 

  19. Adkinson NF Jr, Thompson WL, Maddrey WC, Lichtenstein LM: RoutiCe use of penicillin in skin testing on an in-patient service.N Engl J Med 285 (1971) 22.

    Article  PubMed  Google Scholar 

  20. Warrington RJ, Simons FER, Ho HW, Gorski BA Tse KS: Diagnosis of penicillin allergy by skin testing: the Manitoba experience.CMA J 118 (1978) 787.

    CAS  Google Scholar 

  21. Sogn DD, Casale TB, Condemi JJ, Evans R, Greenberler PA, Kohlder PF, Saxon A, Shepherd GM, Summers RJ, Van Arsdel PP, Levine BB: Interim results of the NIAID collaborative clinical trial of skin testing with major and minor penicillin derivatives in hospitalised adults.J Allergy Clin Immunol 71 (1983) 147.

    Article  Google Scholar 

  22. Wide L, Juhlin L: Detection of penicillin allergy of the immediate type by radioimmunoassay of reagins (IgE) to penicilloyl conjugates.Clin Allergy 1 (1971) 171.

    Article  PubMed  CAS  Google Scholar 

  23. Kraft D, Berglund A, Rumpold H, Roth A, Ebner H: Radioallergosorbent test with conjugates specific for ‘minor’ haptenic determinants in the diagnosis of IgE-mediated penicillin allergy in man.Clin Allergy 11 (1981) 579.

    Article  PubMed  CAS  Google Scholar 

  24. Edwards RG, Spackman DA, Dewdney JM: Development and use of three new radio-allergosorbent tests in the diagnosis of penicillin allergy.Int Arch Allergy Appl Immunol 68 (1982) 352.

    PubMed  CAS  Google Scholar 

  25. Finke SR, Gri co MH, Connell JT, Smith EC, Sherman W: Results of comparativd skin tests with penicilloyl-polylysine an penicillin in patients with penicillin allergy.Am J Med 38 (1965) 71.

    Article  PubMed  CAS  Google Scholar 

  26. Adkinson NF Jr, Wheler B: Risk factors for IgE-dependent reactions to penincillin. Proceedings of the XI International Congress of Allergology and cinical immunology:55 (1983).

  27. Batchelor FR, Dewdney JM, Weston RD, Wheeler AW: The immunogenicity of cephalosporin derivatives and their cross reaction with penicillin.Immunology 10 (1966) 21.

    PubMed  CAS  Google Scholar 

  28. Abraham GN, Petz LD, Fudenberg HH: Immunohaematological cross-allergenicity between penicillin and cephalothin in humans.Clin Exp Immunol 3 (1968) 343.

    PubMed  CAS  Google Scholar 

  29. Girard JP: Common antigenic determinants of penicillin G, ampicillin and the cephaosporins demonstrated in man.Int Arch Allergy 33 (1968) 428.

    PubMed  CAS  Google Scholar 

  30. Assem ESK, Vickers MR: Tests for penicilin allergy in man. II. The immunological cross reaction between penicillins and cephalosporins.Immunol 27 (1974) 255.

    CAS  Google Scholar 

  31. Delafuente JC, Panush RS, Caldwell JR: Penicillin and cephalosporin immunogenicity in man.An Allergy 43 (1979) 337.

    CAS  Google Scholar 

  32. Saxon A, Swabb EA, Adkinson NF: Investigation into the immunologic cross-reactivity of aztreonam with other beta-lactam antibiotics.Am J Med 78 (1985) 19.

    Article  PubMed  CAS  Google Scholar 

  33. Sullivan TJ, Yecies LD, Shatz GS, Parker CW, Wedner HJ: Densensitisation of patients allergic to penicillin using orally administered β-lactam antibiotics.J Alergy Clin Immunol 69 (1982) 275.

    Article  CAS  Google Scholar 

  34. Green GR, Peters GA, Geraci JE: Treatment of bacterial endocarditis in patients with penicillin hypersensitivity.Ann Intern Med 67 (1967) 235.

    PubMed  CAS  Google Scholar 

  35. Reisman RE, Rose NR, Witebskey E, Arbesman C: Penicillin allergy and desensitisation.J Allergy 33 (1962) 178.

    Article  PubMed  CAS  Google Scholar 

  36. Gilmore NJ, Yang WH, Del Carpio J: Penicillin allergy: a simple, rapid intravenous method of “desensitsation”.J Allergy Clin Immunol 63 (1979) 185.

    Google Scholar 

  37. de Weck AL, Schneider CH: Specific inhibition of allergic reactions to penicillin in man by a monovalent hapten: I. Experimental immunological and toxicological studies.Int Arch Allergy Appl Immunol 42 (1972) 789.

    Google Scholar 

  38. de Weck AL, Girard JP: Specific inhibition of allergic reactions to penicillins in man by a monovalent hapten: II. Clinical studies.Int Arch Allergy Appl Immunol 42 (1972) 798.

    PubMed  Google Scholar 

  39. Basomba A, Pelaez A, Villamanzo IG, Campos A: Allergy to penicillin unsuccessfully treated with a haptenic inhibitor (benzyl-penicilloyl-N2-formil-lysine; BPO-Flys.Ciinical Allergy 8 (1978) 341.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Beecham Pharmaceuticals Research Division, Biosciences Research Centre, New Tree Bottom Road, Great Burgh, KT18 5 Q, Epsom, Surrey, England

    R. G. Edwards, L. J. F. Youlten & J. M. Dewdney

Authors
  1. R. G. Edwards
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. J. F. Youlten
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. M. Dewdney
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Edwards, R.G., Youlten, L.J.F. & Dewdney, J.M. Penicillin hypersensitivity: mechanism, diagnosis and management. Indian J Pediatr 53, 37–44 (1986). https://doi.org/10.1007/BF02787072

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02787072

Keywords

Search

Navigation