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Selection of the MHC Class II-associated peptide repertoire by HLA-DM

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Abstract

During the past five years considerable progress has been made in the field of major histocompatibility complex (MHC) class II-restricted antigen presentation. Several observations made in mutant cell lines with a presentation defect led to the identification of a novel protein, the nonclassic MHC class II molecule human leukocye antigen (HLA)-DM. Cell biological and biochemical characterization of HLA-DM provided deeper insight into the molecular mechanism underlying the loading process: HLA-DM accumulates in acidic compartments where it binds to classic class II molecules as long as no high-stability ligand occupies the peptide-binding groove. Thus, HLA-DM prevents empty aβ dimers from functional inactivation in a chaperone-like fashion. At the same time HLA-DM acts as an editor by removing low-stability ligans, thereby skewing the class II peptide repertoire presentable to T-helper cells.

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  1. Departmenl of Molecular Immunology, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany

    Sven O. Arndt, Anne B. Vogt, Günter J. Hämmerling & Harald Kropshofer

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  1. Sven O. Arndt
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  2. Anne B. Vogt
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  3. Günter J. Hämmerling
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  4. Harald Kropshofer
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Arndt, S.O., Vogt, A.B., Hämmerling, G.J. et al. Selection of the MHC Class II-associated peptide repertoire by HLA-DM. Immunol Res 16, 261–272 (1997). https://doi.org/10.1007/BF02786394

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