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The phospholipase-induced degradation of phosphatidylnucleosides


Hydrolysis of phosphatidylnucleosides, 5′-(rac-1-hexadecyl-2-palmitoyl-sn-glycero-3-phosphoryl)-3′-azido-3′-deoxythymidine and -2′,3′-didehydro-3′-deoxythymidine, effected by phospholipases (PL) A2, C, and D was studied to reveal the metabolism of these derivatives. It was shown that PLA2 deacetylates the glycerol residue at position 2, PLC is inactive, and PLD hydrolyzes the phosphatidylnucleosides to give free nucleosides.

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PLA2, PLC, and PLD:

phospholipases A2, C, and D, respectively


egg yolk phosphatidylcholine


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Novozhilova, T.I., Malekin, S.I., Kozhukhov, V.I. et al. The phospholipase-induced degradation of phosphatidylnucleosides. Russ J Bioorg Chem 26, 213–215 (2000).

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Key words

  • anti-HIV activity
  • nucleoside
  • phosphatidylnucleoside
  • phospholipase