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A randomized, controlled trial of octreotide in the management of patients with acute pancreatitis

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Summary

Conclusion

In this study, octreotide was not found to be of benefit in the treatment of acute pancreatitis.

Background

Somatostatin and its long-acting analog octreotide have both been proposed for the treatment of patients with acute pancreatitis, but neither agent has been adequately assessed in patients with severe attacks.

Methods

Fifty-eight patients with moderate or severe acute pancreatitis who were admitted to hospitals within the west of Scotland over an 18-mo period were randomized to receive octreotide, 40 μg/h, by continuous iv infusion for 5 d, or placebo in addition to standard supportive therapy.

Results

There was no significant difference in the incidence of complications (54% octreotide group and 40% placebo group) or mortality (octreotide group 18%; placebo group 20%).

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Authors and Affiliations

  1. Department of Surgery, Glasgow Royal Infirmary, Dumbarton Rd, Glasgow

    John Baxter & Clem Imrie

  2. Department of Surgery, Western Infirmary, Dumbarton Rd, Glasgow, UK

    Colin McKay (Lecture in Surgery)

Authors
  1. Colin McKay
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  2. John Baxter
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  3. Clem Imrie
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McKay, C., Baxter, J. & Imrie, C. A randomized, controlled trial of octreotide in the management of patients with acute pancreatitis. Int J Pancreatol 21, 13–19 (1997). https://doi.org/10.1007/BF02785915

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  • DOI: https://doi.org/10.1007/BF02785915

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