Summary
The morphological, immunohistochemical, and molecular biological features of a case of giant cell tumor of the pancreas are described. This neoplasm showed mononuclear and multinucleated tumor giant cells as well as numerous osteoclast-like cells with multiple foci of osteoid-osseous metaplasia. The pleomorphic and osteoclastic giant cells displayed extensive homologies in their immunohistochemical profiles. Neither the pleomorphic nor osteoclast-like portion of the tumor showed neither c-Ki-ras nor p53 mutation and did not express the mutated p53 protein. The results suggest that the pleomorphic and osteoclast-like components are histogenetically related and that this rare neoplasm originates from a precursor cell capable of differentiating along divergent cell type.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
American Cancer Society. Cancer facts and figures-1989. American Cancer Society, Atlanta, GA, 1989.
Gudjonsson B. Cancer of the pancreas. 50 years of surgery.Cancer 1987; 60: 2284–2303
Cubilla AL, Fitzgerald PJ. Tumours of the exocrine pancreas, inAtlas of Tumor Pathology, 2nd series, fascicle 19, Armed Forces Institute of Pathology, Washington, DC, 1984; pp. 155–167.
Takagi K, Kasumi F, Ohta T, Ohashi T, Takekoshi T, Ohashi K, Maruyama K, Kato I, Nakamura K. Diagnosis of carcinoma of the pancreas. For detection of small carcinoma.Stomach and Intestine 1980; 15: 595–610.
Hsu SM, Raine L, Fanger H. Use of avidin-biotin peroxidase complex in immunoperoxidase technique: a comparison of ABC and an unlabelled antibody (PAP) procedure.J Histochem Cytochem 1981; 29: 577–580.
Mogaki M, Hirota M, Chaney WG, Pour PM. Comparison of p53 protein expression and cellular localization in human and hamster pancreatic cancer cell lines.Carcinogenesis 1993; 14: 2589–2594.
Volkenandt M, Dicker AP, Fanin R, Banerjee D, Albino A, Bertino JR (1993) Polymerase chain reaction analysis of DNA from paraffin-embedded tissue, inPCR Protocols, White BA, eds., Humana, Totowa, NJ, pp. 81–88.
Cha RS, Zarbl H, Keohavong P, Thilly WG. Mismatch Amplication Mutation Assay (MAMA): Application to the c-H-ras Gene.PCR Methods and Applications 2: 14–20, 1992.
Sommers SL, Meissner WA. Unusual carcinoma of the pancreas.Arch Pathol 1954; 58: 101–111.
Tschang T, Garza-Garza R, Kissane JM. Pleomorphic carcinoma of the pancreas. An analysis of 15 cases.Cancer 1977; 39: 2114–2126.
Alguacil-Garcia A, Weiland LH. The histologic spectrum, prognosis and histogenesis of the sarcomatoid carcinoma of the pancreas.Cancer 1977; 39: 1181–1189.
Rosai J. Carcinoma of the pancreas simulating giant cell tumor of bone.Cancer 1968; 22: 333–344.
Jalloh S. Giant cell tumour (osteoclastoma) of the pancreas, an epithelial tumour probably of pancreatic acinar origin.J Clin Pathol 1983; 36: 1165–1170.
Manci EA, Gardner LL, Pollock WJ, Dowling EA. Osteoclastic giant cell tumor of the pancreas. Aspiration cytology, light microscopy and ultrastructure with review of the literature.Diagn Cytopathol 1985; 1: 105–110.
Cubilla AL, Fitzgerald PJ. Cancer of the pancreas (nonendocrine): a suggested morphological classification.Semin Oncol 1979; 6: 285–297.
Trepeta RW, Mathur B, Lagin S, Livolsi V. Giant cell tumor (“osteoclastoma”) of the pancreas: a tumor of epithelial origin.Cancer 1981; 48: 2022–2028.
Posen JA, Path FF. Giant cell tumour of the pancreas of the osteoclastic type associated with a mucous secreting cystoadenocarcinoma.Hum Pathol 1981; 12: 944–947.
Jeffrey I, Crow J, Ellis B. Osteoclast-type giant cell tumour of the pancreas.J Clin Pathol 1983; 36: 1165–1170.
Robinson L, Damjenov I, Brezin P. Multinucleated giant cell neoplasm of the pancreas. Light and electron microscopy features.Arch Pathol Lab Med 1977; 101: 590–593.
Berendt RC, Shnitka TK, Wiens E, Manickavel V, Jewel LD. The osteoclast-type giant cell tumor of the pancreas.Arch Pathol Lab Med 1987; 111: 43–48.
Fisher HP, Ahmannsbergerm M, Cracht J. Osteoclast-type giant cell tumour of the pancreas.Virch Arch (A) 1988; 412: 247–253.
Goldberg RD, Michelassi F, Montag AG. Osteoclast-like giant cell tumor of the pancreas: immunophenotypic similarity to giant cell tumor of bone.Hum Pathol 1991; 6: 618–622.
Combs SG, Hidvegi DF, Ma Y, Rosen ST, Radosevich JA. Pleomorphic carcinoma of the pancreas with osteoclast-like giant cells expressing an epithelial-associated antigen detected by monoclonal antibody 44-3A6.Diagn Cytopathol 1988; 4: 316–322.
Lewandrowski KB, Weston L, Dickersin GR, Ratner DW, Compton CC. Giant cell tumor of the pancreas of mixed osteoclastic and pleomorphic cell type: evidence for a histogenetic relationship and mesenchymal differentiation.Hum Pathol 1990; 21: 1184–1187.
Kim JH, Ho SB, Montgomery C, Kim YS. Cell lineage markers in human pancreatic cancer.Cancer 1990; 66: 2134–2143.
Upton MP, Hiroashi S, Tome J, Miyrawa N, Svemasu K, Shomosato Y. Expression of vimentin in surgically resected adenocarcinoma and large cell carcinoma of the lung.Ann J Surg Pathol 1986; 10: 560–567.
McNutt MA, Bolen JW, Gown AM, Hammar SP, Vogel AM. Coexpression of intermediate filaments in human neoplasms.Ultrastruct Pathol 1985; 9: 31–43.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gatteschi, B., Saccomanno, S., Bartoli, F.G. et al. Mixed pleomorphic-osteoclast-like tumor of the pancreas. Int J Pancreatol 18, 169–175 (1995). https://doi.org/10.1007/BF02785891
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02785891