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The role of Langerhans islets in exocrine pancreatic cancer

International journal of pancreatology volume 17, pages 217–223 (1995)Cite this article

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References

  1. Henderson JR. Why are the islets of Langerhans?Lancet 1969; 2: 469,470.

    PubMed  Article  CAS  Google Scholar 

  2. v. Schönfeld J, Goebell H, Müller MK. The islet-acinar axis of the pancreas.Int J Pancreatol 1994; 16: 131–140.

    Google Scholar 

  3. Kramer MF, Tan HT. The peri-insular acini of the pancreas of the rat.Z Zellforsch 1968; 86: 163–170.

    PubMed  Article  CAS  Google Scholar 

  4. Pour PM, Hauser RE. Exocrine secretion of pancreatic hormones: possible mechanisms.Int J Pancreatol 1987; 2: 277–287.

    PubMed  CAS  Google Scholar 

  5. Bensley RR. Studies on the pancreas of the guinea pig.Am J Anat 1911; 12: 297–302.

    Article  Google Scholar 

  6. Pour PM. Islet cells as a component of pancreatic ductal neoplasms. I. Experimental study. Ductular cells, including islet cell precursors, and primary progenitor cells of tumors.Am J Pathol 1978; 90: 295–316.

    PubMed  CAS  Google Scholar 

  7. Takahashi M, Pour PM. The results of pancreatography during pancreatic carcinogenesis.Am J Pathol 1978; 91: 57–70.

    PubMed  CAS  Google Scholar 

  8. Pour PM. The endocrine-exocrine pancreas: Its clinical and morphological aspects and hyperplastic and neoplastic patterns, inHormone Related Tumors, Nagasawa H, Abe K, eds. Japan Scientific Societies Press, Tokyo, Springer-Verlag, Berlin 1981; pp. 103–120.

    Google Scholar 

  9. Pour PM, Wilson R. Experimental pancreas tumor, inCancer of the Pancreas, Moossa AR, ed. Williams and Wilkins, Baltmore, London 1980; pp. 37–158.

    Google Scholar 

  10. Patent GJ, Alpert M. Histological changes in the pancreatic islets of alloxan-treated mice, with comments on β-cell regeneration.Acta Anat 1964; 28: 341,342.

    Google Scholar 

  11. Bouwens L, Wang R-N, De Blay E, Pipeleers DG, Klöppel G. Cytokeratins as markers of ductal cell differentiation and islet neogenesis in the neonatal rat pancreas.Diabetes 1994; 43: 1279–1283.

    PubMed  Article  CAS  Google Scholar 

  12. Klöppel G, Lenzen S. Anatomy and physiology of the endocrine pancreas, inPancreatic Pathology, Klöppel G, Heitz P, eds. Churchill Livingstone, London, New York 1984; pp. 133–153.

    Google Scholar 

  13. Frantz VK. Tumors of the pancreas, inAtlas of Tumor Pathology, 2nd Sec., Fascicles 27 and 28, Armed Forces Institute of Pathology, Washington, DC, 1959.

    Google Scholar 

  14. Pour PM, Morohoshi T. Ductal Adenocarcinoma, inAtlas of Exocrine Pancreatic Tumors. Morphology, Biology and Diagnosis with an International Guide for Tumor Classification, Pour PM, Konishi Y, Klöppel G, Longnecker DS, eds., Springer-Verlag, Berlin, 1994; pp. 117–154.

    Google Scholar 

  15. Pour PM, Permert J, Mogaki M, Fujii H, Kazakoff K. Endocrine aspects of exocrine cancer of the pancreas. Their patterns and suggested biological significance.Am J Clin Pathol 1993; 100: 223–230.

    PubMed  CAS  Google Scholar 

  16. Eusebi V, Capella C, Bondi A, Sess F, Vezzadini P, Mancini AM. Endocrine-paracrine cells in pancreatic exocrine carcinomas.Histopathology 1981; 5: 599–613.

    PubMed  Article  CAS  Google Scholar 

  17. Pour PM. Experimental panceatic cancer.Am J Surg Pathol 1989; 13: 96–103.

    PubMed  Google Scholar 

  18. Pour P, Mohr U, Cardesa A, Althoff J, Krüger FW. Pancreatic neoplasms, in an animal model: morphological, biological, and comparative studies.Cancer 1975; 36: 379–389.

    PubMed  Article  CAS  Google Scholar 

  19. Pour PM. Induction of unusual pancreatic neoplasms, with morphologic similarity to human tumors, and evidence for their ductal/ductular cell origin.Cancer 1985; 55: 2411–2416.

    PubMed  Article  CAS  Google Scholar 

  20. Pour PM, Runge RG, Birt D, Gingell R, Lawson T, Nagel D, Wallcave L, Salmasi SZ. Current knowledge of pancreatic carcinogenesis in the hamster and its relevance to the human disease.Cancer 1981; 47: 1573–1589.

    PubMed  Article  CAS  Google Scholar 

  21. Pour PM, Egami H, Takiyama Y. Patterns of growth and metastases of induced pancreatic cancer in relation to the prognosis and its clinical implications.Gastroenterology 1991; 100: 529–536.

    PubMed  CAS  Google Scholar 

  22. Egami H, Chaney WG, Takiyama Y, Pour PM. Subcellular localization of blood group A substance produced by pancreatic adenocarcinoma induced in hamsters by N-nitrosobis(2-oxopropyl)amine (BOP) and by its cell line (PC-1).Carcinogenesis 1991; 12: 509–514.

    PubMed  Article  CAS  Google Scholar 

  23. Egami H, Takiyama Y, Chaney WG, Cano M, Fujii H, Tomioka T, Metzgar R, Pour PM. Comparative studies on expression of tumor-associated antigens in human and induced pancreatic cancer in Syrian hamsters.Int J Pancreatol 1990; 7: 91–100.

    PubMed  CAS  Google Scholar 

  24. Takiyama Y, Egami H, Pour PM. Expression of human tumor-associated antigens in pancreatic cancer induced in Syrian hamsters.Am J Pathol 1990; 136: 707–715.

    PubMed  CAS  Google Scholar 

  25. Fujii HH, Egami H, Chaney W, Pour P, Pelting J. Pancreatic ductal adenocarcinomas induced in Syrian hamsters by N-nitrosobis(2-oxopropyl)amine contain a c-Ki-ras oncogene with a point-mutated codon 12.Molec Carcinogenesis 1990; 3: 296–301.

    Article  CAS  Google Scholar 

  26. Mogaki M, Hirota M, Chaney WG, Pour PM. Comparison of p53 protein expression and cellular localization in human and hamster pancreatic cell lines.Carcinogenesis 1993; 14: 2589–2594.

    PubMed  Article  CAS  Google Scholar 

  27. Pour PM, Bell RH. Alteration of pancreatic endocrine cell patterns and their secretion during pancreatic carcinogenesis in the hamster model.Cancer Res 1989; 49: 6396–6400.

    PubMed  CAS  Google Scholar 

  28. Maruchi N, Brian D, Ludwig J, Elveback LR, Kurland LT. Cancer of the pancreas in Olmsted County, Minnesota, 1935–1974.Mayo Clin Proc 1979; 54: 245–249.

    PubMed  CAS  Google Scholar 

  29. Moossa AR, Levin B. Collaborative studies in the diagnosis of pancreatic cancer.Semin Oncol 1979; 6: 298–308.

    PubMed  CAS  Google Scholar 

  30. Wood RA, Schwarz SS, Rubenstein AH, Moossa AR. A prospective evaluation of glucose intolerance in patients suspected of having pancreatic cancer.Br J Surg 1978; 65: 815.

    Article  Google Scholar 

  31. Kessler H. Cancer mortality among diabetics.J Natl Cancer Inst 1970; 44: 673–686.

    PubMed  CAS  Google Scholar 

  32. Ariyama J. Abnormal glucose tolerance in patients with early pancreatic carcinoma.Int J Pancreatol 1994; 16: 91.

    Google Scholar 

  33. Gullo L, Pezzili R, Morselli-Labate AM. Diabetes and the risk of pancreatic cancer.Int J Pancreatol 1994; 16: 94–95.

    Google Scholar 

  34. Permert J, Larsson J, Westermark GT, Herrington MK, Christmanson L, Pour PM, Westermark P, Adrian TE. Islet amyloid polypeptide in patients with pancreatic cancer and diabetes.New Engl J Med 1994; 330: 313–318.

    PubMed  Article  CAS  Google Scholar 

  35. Cersosimo E, Pisters P, Pesola G, McDermott K, Bajorunas D, Brennen MF. Insulin secretion and action in patients with pancreatic cancer.Cancer 1991; 67: 468–493.

    Article  Google Scholar 

  36. Permert J, Ihse I, Jorfeldt L, von Schenk H, Arnqvist HJ, Larsson J. Pancreatic cancer is associated with impaired glucose metabolism.Eur J Surg 1993; 159: 101–107.

    PubMed  CAS  Google Scholar 

  37. Noy A, Bielezikian JP. Clinical Review 63. Diabetes and pancreatic cancer: clues to the early diagnosis of pancreatic malignancy.J Clin Endocrinol Metab 1994; 79: 1223–1231.

    PubMed  Article  CAS  Google Scholar 

  38. Fogar P, Basso D, Panozzo MP, Del Favero G, Briani G, Fabris C, Angeli FD, Meggiato T, Ferrara C, Plebani M. C-peptide patterns in patients with pancreatic cancer.Anticancer Res 1993; 13: 2577–2580.

    PubMed  CAS  Google Scholar 

  39. Ishikawa O, Nakamori S, Ohigashi H, Imaoka S. Increased secretion of proinsulin in patients with pancreatic cancer.Int J Pancreatol 1994; 16: 86–89.

    Google Scholar 

  40. Del Favero G, Basso D, Fogar P, Panozzo MP, Meggiato T, Ferrara C, Angeli F, Bigato L, Plebani M. Alterations of serum pancreatic hormones in pancreatic cancer patients.Int J Pancreatol 1994; 16: 84–86.

    Google Scholar 

  41. Adrian TE, Permert J, Westermark GT. Islet hormones in pancreatic cancer. The association between islet amyloid polypeptide levels and diabetes.Int J Pancreatol 1994; 274–277.

  42. Permert J, Ihse I, Jorfeldt L, von Schenck H, Arqvist H, Larsson J. Improved glucose metabolism after subtotal pancreatectomy for pancreatic cancer.Br J Surg 1993; 80: 1047–1050.

    PubMed  Article  CAS  Google Scholar 

  43. Westermark P, Wernstedt C, Wilander E, Hayden DW, O'Brien TD, Johnson KH. Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a novel polypeptide like protein also present in normal islet cells.Proc Natl Acad Sci USA 1987; 84: 3881–3885.

    PubMed  Article  CAS  Google Scholar 

  44. Leighton B, Cooper GJS. Pancreatic amylin and calcitonin gene-related peptide cause resistance to insulin in skeletal muscle in vitro.Nature 1988; 335: 632–635.

    PubMed  Article  CAS  Google Scholar 

  45. Permert J, Adrian TE, Jacobsson P, Fruin B, Larsson J. Is the peripheral insulin resistance in pancreatic cancer caused by a tumor-associated factor?.Am J Surg 1993; 165: 61–67.

    PubMed  Article  CAS  Google Scholar 

  46. Ahrén B, Andrén-Sandberg A. Glucose tolerance and insulin secretion in experimental pancreatic cancer in the Syrian hamster.Res Exp Med 1993; 193: 21–26.

    Article  Google Scholar 

  47. Adrian TE, Permert J, Westermark GT. Islet hormones in pancreatic cancer. The association between islet amyloid polypeptide levels and diabetes.Int J Pancreatol 1994; 16: 274–277.

    Google Scholar 

  48. Vecchia CL, Negri E, Franceschi S, D'Avanzo B, Boyle P. Diabetes and pancreatic cancer risk. An epidemiological assessment.Int J Pancreatol 1994; 16: 81,82.

    Article  Google Scholar 

  49. Larsson J, Permert J. Relationship between pancreatic cancer and diabetes.Int J Pancreatol 1994; 16: 82–84.

    Google Scholar 

  50. Pour PM. Mechanism of pseudoductular (tubular) formation during pancreatic carcinogenesis in the hamster model.Am J Pathol 1988; 130: 335–344.

    PubMed  CAS  Google Scholar 

  51. Warren S.The Pathology of Diabetes Mellitus, Lea & Feibiger, Philadelphia 1938, 25.

    Google Scholar 

  52. Neubert K. Bau und Entwicklung des menschlichen Pankreas.Arch Entwicklungmechn Organ 1927; 111: 29–118.

    Article  Google Scholar 

  53. Ferner H. Beiträge zur Histobiology der Langerhansschen Inseln des Menschen mit besonderer Berücksichtigung der Silberzellen and ihrer Beziehung zum Pankreas-diabetes.Virchows Arch Pathol Anat 1942; 309: 87–136.

    Article  Google Scholar 

  54. Laidlaw GF. Nesidioblastoma, the islet tumor of the pancreas.Am J Pathol 1938; 14: 125–134.

    Google Scholar 

  55. Bencosme SA. The histogenesis and cytology of the pancreatic islets in the rabbit.Am J Anat 1955; 96: 103–151.

    PubMed  Article  CAS  Google Scholar 

  56. Pour PM, Donnelly K, Stepan K. Modification of pancreatic carcinogenesis in the hamster model. 3. Inhibitory effect of alloxan.Am J Pathol 1983; 110: 310–314.

    PubMed  CAS  Google Scholar 

  57. Pour PM, Patil K. Modification of pancreatic carcinogenesis in the hamster model. X. Effect of streptozotocin.J Natl Cancer Inst 1983; 71: 1059–1065.

    PubMed  CAS  Google Scholar 

  58. Bell RH Jr, Stayer DS. Streptozotocin prevents development of nitrosamine-induced pancreatic cancer in the Syrian hamster.J Surg Oncol 1983; 24: 258–262.

    PubMed  Article  CAS  Google Scholar 

  59. Bell RH, McCullough PJ, Pour PM. Influence of diabetes on susceptibility to experimental pancreatic cancer.Am J Surg 1988; 155: 159–164.

    PubMed  Article  Google Scholar 

  60. Bell RH, Sayers HJ, Pour PM, Ray MB, McCullough PJ. Importance of diabetes in inhibition of pancreatic cancer by streptozotocin.J Surg Res 1989; 46: 515–519.

    PubMed  Article  CAS  Google Scholar 

  61. Pour PM, Kazakoff K, Carlson K. Inhibition of Streptozotocin-induced islet cell tumors and BOP-induced exogenous pancreatic tumors in Syrian hamsters.Cancer Res 1990; 50: 1634–1639.

    PubMed  CAS  Google Scholar 

  62. Bell RH, Pour PM. Induction of pancreatic tumors in genetically non-diabetic but not in diabetic Chinese hamsters.Cancer Lett 1987; 34: 221–230.

    PubMed  Article  CAS  Google Scholar 

  63. Ishikawa O, Ohigashi H, Imaoka S, Nakai I, Mitsuo M, Pour PM. The role of pancreatic islets in experimental pancreatic carcinogenicity.Am J Pathol (submitted).

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  1. UNMC/Eppley Cancer Center, University of Nebraska Medical Center, 600 S. 42nd St., 68198-6805, Omaha, NE

    Parviz M. Pour

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Pour, P.M. The role of Langerhans islets in exocrine pancreatic cancer. Int J Pancreatol 17, 217–223 (1995). https://doi.org/10.1007/BF02785817

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Key Words

  • Islet
  • pancreatic cancer
  • diabetes
  • endocrine
  • exocrine
  • pancreas
  • cancer induction
  • hamster
  • human