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Protective effects of GSH, vitamin E, and selenium on lipid peroxidation in cadmium-fed rats

Abstract

Increased intake of Cd results in its retention and in peroxidative damage in soft tissues. Coadministration of antioxidants, viz., glutathione (GSH), α-tocopherol, and Se, restricted the uptake and distribution of Cd in liver and kidney of rats. Moreover, no rise in malondialdehyde was recorded. Although possible antioxidative mechanisms manifested by GSH, α-tocopherol, and Se have been discussed, it is hypothesized that GSH functions as a Cd chelator. Glutathione yielded favorable effects in comparison to Se and α-tocopherol.

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Rana, S.V.S., Verma, S. Protective effects of GSH, vitamin E, and selenium on lipid peroxidation in cadmium-fed rats. Biol Trace Elem Res 51, 161–168 (1996). https://doi.org/10.1007/BF02785435

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  • DOI: https://doi.org/10.1007/BF02785435

Index Entries

  • Cadmium
  • glutathione
  • α-tocopherol
  • selenium
  • malondialdehyde