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Effects of aluminum chloride on normal and uremic adult male rats

Tissue distribution, brain choline acetyltransferase activity, and some biological variables

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Abstract

Normal and uremic adult male rats were given a daily ip injection of 20 mg Al (Al chloride)/kg for 14 d. The results indicate that Al induces a significant decrease in food ingestion, weight gain, and total protein concentration in the plasma. Compared with control animals, very high increases in Al levels were found in plasma and hepatic homogenates (about 36 and 19 times, respectively). In the brain homogenates, the Al increases were lower (about 23%). The brain cholineacetyltransferase activity was reduced: 10.6 and 14.9% in normal and uremic rats, respectively. The nephrectomy and the food restriction did not affect the total protein concentrations in plasma and the cerebral cholineacetyltransferase activity. Both were only found to be reduced in the rats treated by Al chloride.

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Authors and Affiliations

  1. Centre des Sciences de l’Environnement, Toxicologie, Université de Metz, (France)

    G. Cherroret

  2. Laboratoire de Biologie et Physiologie du Comportement, URA CNRS 1293, Faculté des Sciences, Université Henri Poincaré, Nancy 1, 54500, Vandoeuvre les Nancy Cedex, France

    D. Desor & P. R. Lehr

  3. Service de Chimie Générale appliquée àla Médecine, Faculté de Médecine, Université Henri Poincaré, Nancy 1, Nancy, France

    M. F. Hutin & D. Burnel

  4. Laboratoire de Biochimie, CHR Metz-Thionville, Thionville, France

    B. Capolaghi

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  1. G. Cherroret
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Cherroret, G., Desor, D., Hutin, M.F. et al. Effects of aluminum chloride on normal and uremic adult male rats. Biol Trace Elem Res 54, 43–53 (1996). https://doi.org/10.1007/BF02785319

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  • DOI: https://doi.org/10.1007/BF02785319

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