Abstract
Alveolar macrophages collected by pulmonary lavage from male Fisher-344 rats at intervals (24–72 h) after HgCl2 injection (1–5 mg/kg, sc) were analyzed by several techniques. Within 24–72 h, the macrophages showed morphological signs of activation (hypertrophy and ruffled plasma membrane). Lipid peroxidation (increased malondialdehyde concentration) was not detected until 48 h. Dose- and time-related effects of HgCl2 on malondialdehyde concentration and time-related effects of HgCl2 on malondialdehyde concentration and mercury content of alveolar macrophages were observed 24–72 h postinjection. Diminished cell viability occurred only at 72 h after the highest dosage of HgCl2. This study demonstrates that the alveolar macrophage was a cellular target for mercury toxicity following parenteral exposure to HgCl2.
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Huang, YL., Lin, TH. Toxicity to alveolar macrophages in rats following parenteral injection of mercuric chloride. Biol Trace Elem Res 54, 1–8 (1996). https://doi.org/10.1007/BF02785315
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DOI: https://doi.org/10.1007/BF02785315