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Submaximal, aerobic exercise training exacerbates the cardiomyopathy of postweanling Cu-depleted rats

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Abstract

To determine the dual effect of exercise training and copper depletion on myocardial function and ultrastructure, postweanling rats were either trained or sedentary while fed copper-adequate or copper-deficient diets for 8 wk. Rats developed characteristic myocardial subcellular degeneration and increased cardiac mitochondrial volume density when copper depleted, despite lack of overt cardiac hypertrophy, hypertension, or anemia. Training combined with copper depletion induced mild left ventricular hypertrophy. Basal laminae appeared fractionated in areas at capillary-myocyte interface, with focal pericapillary and interstitial collagen accumulation, where-as overt fibrosis was absent or minimal. Electrocardiograms revealed increased QRS wave and QT duration and notching of QRS complex with copper depletion, consistent with intraventricular conductance disturbances. The oxidative capacity of soleus muscle increased with training in copper-adequate rats, but was reduced with progressive copper depletion. These data suggest that copper depletion and training are synergistic in effecting focal accumulation of collagen, with deleterious effect on exercise capacity.

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Authors and Affiliations

  1. Department of Human Nutrition and Food Management, The Ohio State University, 265 Campbell Hall 1787 Neil Avenue, 43210-1295, Columbus, OH

    Jeannette Davidson, Denis M. Medeiros & James E. Jenkins

  2. Department of Veterinary Physiology and Pharmacology, The Ohio State University, 43210-1006, Columbus, OH

    Robert L. Hamlin

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  1. Jeannette Davidson
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  2. Denis M. Medeiros
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  3. Robert L. Hamlin
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  4. James E. Jenkins
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Davidson, J., Medeiros, D.M., Hamlin, R.L. et al. Submaximal, aerobic exercise training exacerbates the cardiomyopathy of postweanling Cu-depleted rats. Biol Trace Elem Res 38, 251–272 (1993). https://doi.org/10.1007/BF02785310

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  • DOI: https://doi.org/10.1007/BF02785310

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