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Copper organo-chelators inAspergillus fumigatus andPenicillium chrysogenum

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Abstract

The presence of copper in the growth medium induces the biosynthesis of several low-mol-wt copper ogano-chelators inAspergillus fumigatus andPenicillium chrysogenum. By use ofP. chrysogenum, we were able to prepare several low-mol-wt metallothionein chelators, as well as several short-chain copper chelatins. The amino acid composition of a chelatin of mol wt approx 799 Da revealed the presence of cysteine, glutamic acid, glycine, and leucine. Use ofA. fumigatus led to fewer copper chelators and one very short-chain peptide: a chelatin of mol wt approx 624 Da. composed of four amino acids, asparagine, glutamic acid, cysteine, and glycine. These results may confirm our assumption that fungi detoxify the deleterious action of toxic elements by producing high levels of heavy metal chelators/chelatins.

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References

  1. A. G. Massey, inComprehensive Inorganic Chemistry, vol. 3, J. C. Bailar, Jr., H. J. Emele’us, R. Nyholm, and A. F. Trotman-Dickenson, eds., Pergaman Press, Oxford, 1973, pp. 1–78.

    Google Scholar 

  2. U. Weser,Metalloproteins. Georg Thieme Verlag Stuttgart, New York, 1979.

    Google Scholar 

  3. R. Premakumar, D. R. Winge, R. D. Wiley, and K. V. Rajagopalan,Biochim. Biophys. Acta,493, 465–477 (1977).

    Google Scholar 

  4. R. Prinz and U. Weser,Z. Physiol. Chem. 356, 767–776 (1975).

    CAS  Google Scholar 

  5. D. E. Salt, D. A. Thurman, A. B. Tomsett, and A. K. Sewell,Proc. R. Soc. Lond. B 236, 79–89 (1989).

    CAS  Google Scholar 

  6. A. A. Razak, M. A. El-Meleigy, and E. A. Ghonamy,Az. J. Microbiol. 8, 225–235 (1990).

    Google Scholar 

  7. A. A. Razak, E. A. Ghonamy, and M. A. El-Meleigy,Az. J. Microbiol. 8, 249–258 (1990).

    Google Scholar 

  8. S. E. Ramadan, A. A. Razak, A. M. Ragab, and M. A. El-Meleigy,Biol. Trace. Elem. Res. 20, 225–232 (1989).

    PubMed  CAS  Google Scholar 

  9. O. H. Lowry, N. J. Rosebrough, A. L. Furr, and R. J. Randall,J. Biol. Chem. 193, 265–275 (1951).

    PubMed  CAS  Google Scholar 

  10. A. A. Razak and S. E. Ramadan,Egypt. J. Microbiol. 19, 193 (1984).

    CAS  Google Scholar 

  11. A. M. Ragab, S. E. Ramadan, A. A. Razak, and E. A. Ghonamy, inPerspectives in Biotechnology and Applied Microbiology, D. I. Alani and M. Mooyouny, eds., Elsevier, London, 1986, pp. 343–353.

    Google Scholar 

  12. A. A. Razak, S. E. Ramadan, A. M. Ragab, and M. A. El-Meleigy,J. Fac. Edu. Ain Shams Univ. 13, 433 (1988).

    Google Scholar 

  13. A. A. Razak, S. E. Ramadan, and K. El Zawahry,Biol. Trace Elem. Res. 25, 193–199 (1990).

    Article  PubMed  CAS  Google Scholar 

  14. I. M. Abbass and A. A. Razak,Biol. Trace Elem. Res. 28, 173–179 (1991).

    PubMed  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Botany, Faculty of Science for Girls, AL-Azhar University, Madinet Nasr, Cairo, Egypt

    Magda A. El-Meleigy

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  1. Magda A. El-Meleigy
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El-Meleigy, M.A. Copper organo-chelators inAspergillus fumigatus andPenicillium chrysogenum . Biol Trace Elem Res 34, 177–183 (1992). https://doi.org/10.1007/BF02785245

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  • DOI: https://doi.org/10.1007/BF02785245

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