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Disturbances in heme biosynthesis in rabbits after administrationper os of low doses of tin or lead

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Abstract

The experiment was performed on female rabbits that receivedper os equimolar doses (17 μM Me/kg) of SnCl2×2H2O or Pb (CH3 COO)2 every day for 5 d. The activity of δ-aminolevulinic acid dehydratase (ALA-D) in the whole blood, liver, kidneys, brain, spleen, and bone marrow, concentration of free erythrocyte protoporphyrins (FEP), activity of δ-aminolevulinic acid synthetase (ALA-S) in the liver and bone marrow, urine δ-aminolevulinic acid (ALA-U), and coproporphyrins (CP-U) were determined. Lead and tin concentrations in the blood were estimated.

Lead caused a significant inhibition of ALA-D in the blood, increased FEP concentration, and ALA and CP excretion in urine of rabbits. Lead also decreased ALA-D activity in the bone marrow and in the liver, and did not change ALA-2 activity in the liver and bone marrow.

Tin did not change any of the examined indices. Tin doses applied in the present study, maintained within the limits of permissible standards of metal levels in human diet, did not affect the process of heme biosynthesis in rabbits.

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Authors and Affiliations

  1. Department of Toxicological Chemistry, Institute of Environmental Research and Bioanalysis, Medical Academy of Lódź, Muszyńskiego 1, 90-151, Lódź, Poland

    Grazyna Zareba & Jadwiga Chmielnicka

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  1. Grazyna Zareba
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  2. Jadwiga Chmielnicka
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Zareba, G., Chmielnicka, J. Disturbances in heme biosynthesis in rabbits after administrationper os of low doses of tin or lead. Biol Trace Elem Res 34, 115–122 (1992). https://doi.org/10.1007/BF02785241

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  • DOI: https://doi.org/10.1007/BF02785241

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