Abstract
The plasma levels of apo B and apo E, and the level of hepatic and intestinal mRNA coding for these apolipoproteins were investigated in weanling male rats pair-fed for 6 wk with a control or copperdeficient diet. Plasma cholesterol, triglycerides, and phospholipids were significantly increased, and plasma apo B and apo E levels were also markedly increased in copper-deficient rats as compared to control rats. Copper deficiency significantly increased triglyceride levels and decreased cholesterol levels in the liver. No major differences in the levels of hepatic and intestinal apo B and apo E mRNA occurred between control and copper-deficient rats. These data imply that hypertriglyceridemia dn hypercholesterolemia owing to the copper deficiency are not accompanied by modifications in the gene expression at the mRNA level in the liver and intestine of the apolipoproteins studied.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
L. M. Klevay,Am. J. Clin. Nutr. 26, 1060 (1973).
K. Y. Lei,J. Nutr. 113, 2178 (1983).
M. S. J. Shao and K. Y. Lei,J. Nutr. 110, 859 (1980).
C. A. Hassel, T. P. Carr, and K. Y. Lei,Nutr. Res. 10, 903 (1990).
N. Y. Yount, D. J. McNamara, A. Al-Othman, and K. Y. Lei,J. Nutr. Biochem.,1, 21 (1990).
S. I. Koo, C. C. Lee, and J. E. Norvell,Proc. Soc. Exp. Biol. Med. 188, 410 (1988).
B. W. C. Lau and L. M. Klevay,J. Nutr. 111, 1698 (1981).
R. W. Mahley, T. L. Innerarity, S. C. Rall, and K. H. Weisgraber,J. Lipid Res. 25, 1277 (1984).
S. Reiser, R. J. Ferretti, M. Fields, and J. C. Smith, Jr.Am. J. Clin. Nutr. 38, 214 (1983).
P. A. Mayes and M. E. Laker,Prog. Biochem. Pharmacol. 21, 33 (1986).
Y Rayssiguier, E. Gueux, and D. Weiser,J. Nutr. 111, 1876 (1981).
A. Mazur, C. Rémésy, E. Gueux, M. A. Levrat, and C. Demigné,J. Nutr. 120, 1037 (1990).
G. R. Bartlett,J. Biol. Chem. 234, 466 (1959).
C. B. Laurell,Anal. Biochem. 15, 45 (1966).
P. Chomczynski and N. Sacchi,Anal. Biochem. 162, 156 (1987).
M. Mangeney, P. Cardot, S. Lyonnet, C. Coupe, R. Benarous, A. Munnich, J. Girard, J. Chambaz, and G. BéréziatEur. J. Biochem. 181, 225 (1989).
A. Ribeiro, M. Mangeney, P. Cardot, C. Loriette, Y. Rayssiguier, J. Chambaz, and G. Béréziat,Eur. J. Biochem. 196, 499 (1991).
S. C. Croswell and K. Y. Lei,J. Nutr. 115, 473 (1985).
D. B. Ray, C. C. Lee, and S. I. Koo,FASEB J. 3, A1062 (1990).
P. W. Harvey and K. G. D. Allen,Nutr. Res. 5, 511 (1985).
A. A. Al-Othman, F. Rosenstein, and K. Y. Lei,FASEB J. 4, A393 (1990).
M. Fields and Ch. G. Lewis inMetal Ions in Biology and Medicine, Ph. Collery, L. A. Poirier, M. Monfait, and J. C. Etienne, eds., John Libbey Eurotext, Paris, 1990, pp. 80–83.
A. Ribeiro, M. Mangeney, P. Cardot, C. Loriette, J. Chambaz, Y. Rayssiguier, and G. Béréziat.Diabète & Métabolisme (in press).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mazur, A., Nassir, F., Gueux, E. et al. The effect of dietary copper on rat plasma apolipoprotein B, E plasma levels, and apolipoprotein gene expression in liver and intestine. Biol Trace Elem Res 34, 107–113 (1992). https://doi.org/10.1007/BF02785240
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02785240