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Effects of a multivitamin mineral supplement on zinc and copper status during pregnancy

  • Part 2: Trace elements in endocrinology
  • Section 5: Reproduction, Growth, and Immunity
  • Published:
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Abstract

The effect of a multivitamin-mineral supplement was investigated during pregnancy according to a double-blind protocol by determining zinc and copper in maternal plasma, mononuclear and polynuclear zinc and copper at the third, sixth, eighth, and ninth months of gestation. The subjects were supplemented from the first trimester until delivery. A significant decrease was observed in plasma zinc that varied from 11.5 μmol/L to 10.8 μmol/L in the supplemented group (n=29) and from 11 μmol/L to 10 μmol/L in the placebo group (n=33) at 3 and 9 mo of gestation, respectively. In contrast, plasma copper levels increased in a way depending upon the stage of gestation in both groups: from 24.7 to 28.2 μmol/L in the treated group and from 24.9 to 30.9 μmol/L in the placebo group at 3 and 9 mo of gestation, respectively, but the difference was only significant in the placebo group. No difference between groups was observed in mononuclear and polynuclear zinc or copper levels.

These trace elements were also determined in cord blood at delivery. There were no statistically significant differences in zinc and copper concentration found in placebo group and supplemented group. Finally, the beneficial effect of supplementation on muscular cramps and appearance of vergetures was noted.

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Authors and Affiliations

  1. Laboratoire de Biochimie C, Centre Hospitalier Régional Universitaire de Grenoble, BP 217X, 38043, Grenoble cedex 09, France

    Estelle Thauvin, Josiane Arnaud, Henri Faure, Charles Coudray, Marie-Jeanne Richard & Alain Favier

  2. Laboratoire Aguettant, rue A. Fleming, 69007, Lyon, France

    Michelle Fusselier

  3. Service de gynécologie-obstétrique, Centre Hospitalier Régional Universitaire de Grenoble, BP 217X, 38043, Grenoble cedex 09, France

    Max Favier

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  1. Estelle Thauvin
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Thauvin, E., Fusselier, M., Arnaud, J. et al. Effects of a multivitamin mineral supplement on zinc and copper status during pregnancy. Biol Trace Elem Res 32, 405–414 (1992). https://doi.org/10.1007/BF02784626

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