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Effect of acute zinc deficiency on insulin receptor binding in rat adipocytes

  • Part 2: Trace elements in endocrinology
  • Section 3: Diabetes and Glucose Tolerance
  • Published:
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Abstract

Considerable data have been reported on the relationship between insulin resistance and zinc deficiency. In this study, insulin receptor binding was measured in isolated rat adipocytes. Two assays were carried out at 37°C (binding and internalization) and 16°C (binding) using125I insulin 0.05–20 nM. A decreased insulin receptor binding was observed in zinc-deficient rat adipocytes, but we could not make any distinction between the specific zinc depletion effects and the effects of the caloric restriction induced by zinc deficiency.

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Authors and Affiliations

  1. Laboratoire de Biochimie C, Hôpital A. Michallon, BP217 X, 38043, Grenoble Cédex, France

    Marie Jeanne Gomot, Patrice Faure, Charles Coudray & Alain Favier

  2. Laboratoire de Biochimie C, UFR de Pharmacie, 38700, La Tronche, France

    Anne-Marie Roussel & Mireille Osman

Authors
  1. Marie Jeanne Gomot
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  2. Patrice Faure
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  3. Anne-Marie Roussel
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  4. Charles Coudray
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  5. Mireille Osman
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  6. Alain Favier
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Gomot, M.J., Faure, P., Roussel, AM. et al. Effect of acute zinc deficiency on insulin receptor binding in rat adipocytes. Biol Trace Elem Res 32, 331–335 (1992). https://doi.org/10.1007/BF02784619

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  • DOI: https://doi.org/10.1007/BF02784619

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